B-HT 933 DIHYDROCHLORIDE
- Product Name
- B-HT 933 DIHYDROCHLORIDE
- CAS No.
- 36067-72-8
- Chemical Name
- B-HT 933 DIHYDROCHLORIDE
- Synonyms
- b-ht933;Nsc310831;Azepexole hydrochloride;B-HT 933 (hydrochloride);Azepexole dihydrochloride;β2AR/M3-receptor agonist-1;B-HT 933 DIHYDROCHLORIDE SELECTIVE A2 AD RENORE;5-d)azepin-2-amine,5,6,7,8-tetrahydro-6-ethyl-4h-oxazolo(dihydrochloride;5,6,7,8-tetrahydro-6-ethyl-4h-oxazolo(4,5-d)azepin-2-aminedihydrochloride;2-amino-6-ethyl-4,5,7,8-tetrahydro-6h-oxazolo(5,4-d)azepinedihydrochloride
- CBNumber
- CB9496972
- Molecular Formula
- C9H16ClN3O
- Formula Weight
- 217.7
- MOL File
- 36067-72-8.mol
B-HT 933 DIHYDROCHLORIDE Property
- storage temp.
- Desiccate at RT
- solubility
- H2O: >20 mg/mL
- form
- solid
- color
- white to off-white
Safety
- WGK Germany
- 2
- RTECS
- RQ5831345
N-Bromosuccinimide Price
- Product number
- 11941
- Product name
- B-HT 933 (hydrochloride)
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 11941
- Product name
- B-HT 933 (hydrochloride)
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $139
- Updated
- 2024/03/01
- Product number
- 11941
- Product name
- B-HT 933 (hydrochloride)
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $199
- Updated
- 2024/03/01
- Product number
- 11941
- Product name
- B-HT 933 (hydrochloride)
- Purity
- ≥95%
- Packaging
- 25mg
- Price
- $456
- Updated
- 2024/03/01
- Product number
- H671813
- Product name
- B-HT933Dihydrochloride
- Packaging
- 25mg
- Price
- $215
- Updated
- 2021/12/16
B-HT 933 DIHYDROCHLORIDE Chemical Properties,Usage,Production
Description
B-HT 933 is an agonist of α2-adrenergic receptors (α2-ARs) with an EC50 value of 0.65 μM for contraction of canine sapheneous veins. It induces concentration-dependent inhibition of the twitch response in rat vas deferens and guinea pig ileum. B-HT 933 induces sedation and reduces motor activity in mice, an effect that is reversed by the α2-AR antagonist yohimbine . B-HT 933 decreases blood pressure and cardiac output in cats injected with 30 μg/kg intracisternally. It also exhibits antinociceptive effects in mice with ED50 values of 12.5, 20.5, and 6.1 mg/kg for the tail-immersion, tail-pinch, and acetic acid writhing tests, respectively.
Uses
B-HT 933 Dihydrochloride is a selective α2-adrenoceptor agonist and has less potent inhibitory effect on the sympathetic vasopressor responses in diabetic rats.
in vitro
b-ht 933, a selective α2-adrenoceptor agonist, contracts human subcutaneous resistance arteries by a mechanism largely dependent on the influx of extracellular ca2+, probably through voltage-operated calcium channels. this action involves a pertussis toxin-sensitive g protein, possibly gq [1].
in vivo
the dose-related effects of the selective α2-adrenoceptor agonist b-ht 933 on the body temperature of untreated and reserpine-treated mice were investigated. in untreated mice b-ht 933 induced a dose-related hypothermia. the highest dose of b-ht 933 elicited a marked hypothermia, whereas the maximal hypothermic effect of clonidine was less pronounced and reached a plateau at a dose of 0.5 mg/kg [2].
IC 50
0.44 μm
storage
Desiccate at RT
References
[1] n. a. parkinson & a.d. hughes. the mechanism of action of 1c2-adrenoceptors in human isolated subcutaneous resistance arteries. british journal of pharmacology (1995) 115, 1463-1468
[2] d. j. bill, i.e. hughes & r.j. stephens. the thermogenic actions of x2-adrenoceptor agonists in reserpinized mice are mediated via a central postsynaptic ac2-adrenoceptor mechanism. br. j. pharmacol. (1989), 96, 133-143