ChemicalBook > CAS DataBase List > BISPHENOL A-(3-CHLORO-2-HYDROXYPROPYL)-&

BISPHENOL A-(3-CHLORO-2-HYDROXYPROPYL)-&

Product Name: BISPHENOL A-(3-CHLORO-2-HYDROXYPROPYL)-&
CAS No.: 227947-06-0
Chemical Name: BISPHENOL A-(3-CHLORO-2-HYDROXYPROPYL)-&
Synonyms: CS-2260;EPI-001;BADGE-HCl-H2O;EPI-001, 10 mM in DMSO;BISPHENOL A 3-CHLORO-2-HYDROXYPROPYL DIH;BISPHENOL A-(3-CHLORO-2-HYDROXYPROPYL)-&;3-(4-(2-(4-(3-chloro-2-hydroxypropoxy)phenyl)propan-2-yl)phenoxy)propane-1,2-diol;3-[4-[1-[4-(3-Chloro-2-hydroxypropoxy)phenyl]-1-methylethyl]phenoxy]-1,2-propanediol;2-[4-(3-chloro-2-hydroxypropyloxy)phenyl]-2-[4-(2,3-dihydroxypropyloxy)phenyl]propane;1,2-Propanediol, 3-[4-[1-[4-(3-chloro-2-hydroxypropoxy)phenyl]-1-methylethyl]phenoxy]-
CBNumber: CB9497287
Molecular Formula: C21H27ClO5
Formula Weight: 394.89
MOL File: 227947-06-0.mol

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BISPHENOL A-(3-CHLORO-2-HYDROXYPROPYL)-& Property

Melting point:: 67 °C
Boiling point:: 601.0±55.0 °C(Predicted)
Density: 1.228±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: soluble15mg/mL, clear
pka: 13.13±0.20(Predicted)
form: powder
color: white to beige
InChI: InChI=1S/C21H27ClO5/c1-21(2,15-3-7-19(8-4-15)26-13-17(24)11-22)16-5-9-20(10-6-16)27-14-18(25)12-23/h3-10,17-18,23-25H,11-14H2,1-2H3
InChIKey: HDTYUHNZRYZEEB-UHFFFAOYSA-N
SMILES: C(O)C(O)COC1=CC=C(C(C2=CC=C(OCC(O)CCl)C=C2)(C)C)C=C1

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
HS Code: 29072300

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 92427
Product name: Bisphenol A (3-chloro-2-hydroxypropyl) (2,3-dihydroxypropyl) ether
Purity: analytical standard
Packaging: 25mg
Price: $247
Updated: 2025/07/31

Sigma-Aldrich

Product number: 92427
Product name: Bisphenol A (3-chloro-2-hydroxypropyl) (2,3-dihydroxypropyl) ether
Purity: analytical standard
Packaging: 100mg
Price: $513.8
Updated: 2025/07/31

TCI Chemical

Product number: E1380
Product name: EPI-001
Packaging: 5MG
Price: $71
Updated: 2025/07/31

TCI Chemical

Product number: E1380
Product name: EPI-001
Packaging: 25MG
Price: $213
Updated: 2025/07/31

Cayman Chemical

Product number: 16970
Product name: EPI-001
Purity: ≥95%
Packaging: 5mg
Price: $57
Updated: 2024/03/01

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BISPHENOL A-(3-CHLORO-2-HYDROXYPROPYL)-& Chemical Properties,Usage,Production

Uses

EPI-001 is a selective peroxisome proliferator-activated receptor-gamma modulator that inhibits androgen receptor expression and activity in prostate cancer. It is a novel androgen receptor antagonists that has the potential for treating prostate cancer.

Definition

ChEBI: Bisphenol A (3-chloro-2-hydroxypropyl) (2,3-dihydroxypropyl) ether is the (3-chloro-2-hydroxypropyl) (2,3-dihydroxypropyl) diether of bisphenol A; a small molecule that inhibits transactivation of the AR amino-terminal domain (NTD). It has a role as an androgen antagonist. It is an organochlorine compound and a diether. It is functionally related to a bisphenol A and a glycerol.

Biological Activity

epi-001 is a small-molecule inhibitor of androgen receptor n-terminal domain. epi-001 could target the amino terminal domain of the ar and inhibit the protein-protein interactions which are necessary for ar transcriptional activity. the androgen receptor (ar) is involved in mediating the actions of male sex steroids. amplification and over-expression of androgen receptor gene may result in hormone-refractory prostate cancer [1].

in vitro

epi-001 inhibited the ligand-dependent argal4 transcriptional activity in lncap cells and the ligand-independent argal4 transcriptional activity in the crpc c4-2 cell line. in a panel of cell lines, epi-001 treatment decreased the mrna expression level of ar protein after 8 and 16 h treatment, such as androgen sensitive pca, crpc, lncap, c4-2, and lapc4 cell line. epi-001 dose-dependently inhibited the pca/crpc cell growth [2].

in vivo

intravenous injection of epi-001 significantly reduced the weight of benign prostates and blocked the growth of prostate cancer xenograft from noncastrated mature mice. epi-001 caused tumor regression of crpc. in male mice bearing lncap xenografts, after treated with epi- 001 by i.v. injection for 2 weeks, the tumor size was less than half of the control group [3].

References

andersen r j, mawji n r, wang j, et al. regression of castrate-recurrent prostate cancer by a small-molecule inhibitor of the amino-terminus domain of the androgen receptor[j]. cancer cell, 2010, 17(6): 535-546.brand l j, olson m e, ravindranathan p, et al. epi-001 is a selective peroxisome proliferator-activated receptor-gamma modulator with inhibitory effects on androgen receptor expression and activity in prostate cancer[j]. oncotarget, 2015, 6(6): 3811.sadar m d. small molecule inhibitors targeting the “achilles' heel” of androgen receptor activity[j]. cancer research, 2011, 71(4): 1208-1213.

BISPHENOL A-(3-CHLORO-2-HYDROXYPROPYL)-& Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from BISPHENOL A-(3-CHLORO-2-HYDROXYPROPYL)-& manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: EPI-001 227947-06-0
Price: US $3.00-9.00/kg
Min. Order: 1kg
Purity: 99%min
Supply Ability: 50kg
Release date: 2025-07-28

Career Henan Chemical Co

Product: BISPHENOL A-(3-CHLORO-2-HYDROXYPROPYL)-& 227947-06-0
Price: US $1.00/KG
Min. Order: 1KG
Purity: 95--99%
Supply Ability: 1ton
Release date: 2020-01-08

227947-06-0, BISPHENOL A-(3-CHLORO-2-HYDROXYPROPYL)-&Related Search:

Bisphenol A Impurity 8 Phenol Polycarbonate 4,4'-DIHYDROXYDIPHENYLMETHANE Epichlorohydrin MFCD02018974 BISPHENOL A DIGLYCIDYL ETHER RESIN Bisphenol A Impurity 7 Bisphenol A 4-[1-(4-hydroxyphenyl)-1-methylethyl]benzene-1,2-diol BISPHENOL F DIGLYCIDYL ETHER Bisphenol A impurity 2 Bisphenol A Impurity 3-d8 Bisphenol A impurity 5 Bisphenol A Impurity 2-d8 Bisphenol A Impurity 9-d4 Bisphenol A Impurity 6-d8 Bisphenol A Impurity 5-d8

CS-2260

BISPHENOL A-(3-CHLORO-2-HYDROXYPROPYL)-&

BISPHENOL A 3-CHLORO-2-HYDROXYPROPYL DIH

2-[4-(3-chloro-2-hydroxypropyloxy)phenyl]-2-[4-(2,3-dihydroxypropyloxy)phenyl]propane

BADGE-HCl-H2O, 2-[4-(3-Chloro-2-hydroxypropyloxy)phenyl]-2-[4-(2,3-dihydroxypropyloxy)phenyl]propane

Bisphenol A (3-chloro-2-hydroxypropyl) (2,3-dihydroxypropyl) ether,2-[4-(3-Chloro-2-hydroxypropyloxy)phenyl]-2-[4-(2,3-dihydroxypropyloxy)phenyl]propane, BADGE-HCl-H2O

BADGE-HCl-H2O

EPI-001

3-[4-[1-[4-(3-Chloro-2-hydroxypropoxy)phenyl]-1-methylethyl]phenoxy]-1,2-propanediol

3-(4-(2-(4-(3-chloro-2-hydroxypropoxy)phenyl)propan-2-yl)phenoxy)propane-1,2-diol

1,2-Propanediol, 3-[4-[1-[4-(3-chloro-2-hydroxypropoxy)phenyl]-1-methylethyl]phenoxy]-

Androgen,amino-terminal,anti-tumor,domain,PPAR,inhibit,EPI-001,Peroxisome proliferator-activated receptors,PPARγ,Apoptosis,transactivation,Receptor,NTD,Androgen Receptor,Inhibitor

EPI-001, 10 mM in DMSO

227947-06-0

C21H27ClO5