BISPHENOL A-(3-CHLORO-2-HYDROXYPROPYL)-&
- Product Name
- BISPHENOL A-(3-CHLORO-2-HYDROXYPROPYL)-&
- CAS No.
- 227947-06-0
- Chemical Name
- BISPHENOL A-(3-CHLORO-2-HYDROXYPROPYL)-&
- Synonyms
- CS-2260;EPI-001;BADGE-HCl-H2O;BISPHENOL A 3-CHLORO-2-HYDROXYPROPYL DIH;BISPHENOL A-(3-CHLORO-2-HYDROXYPROPYL)-&;3-(4-(2-(4-(3-chloro-2-hydroxypropoxy)phenyl)propan-2-yl)phenoxy)propane-1,2-diol;3-[4-[1-[4-(3-Chloro-2-hydroxypropoxy)phenyl]-1-methylethyl]phenoxy]-1,2-propanediol;2-[4-(3-chloro-2-hydroxypropyloxy)phenyl]-2-[4-(2,3-dihydroxypropyloxy)phenyl]propane;1,2-Propanediol, 3-[4-[1-[4-(3-chloro-2-hydroxypropoxy)phenyl]-1-methylethyl]phenoxy]-;BADGE-HCl-H2O, 2-[4-(3-Chloro-2-hydroxypropyloxy)phenyl]-2-[4-(2,3-dihydroxypropyloxy)phenyl]propane
- CBNumber
- CB9497287
- Molecular Formula
- C21H27ClO5
- Formula Weight
- 394.89
- MOL File
- 227947-06-0.mol
BISPHENOL A-(3-CHLORO-2-HYDROXYPROPYL)-& Property
- Melting point:
- 67 °C
- Boiling point:
- 601.0±55.0 °C(Predicted)
- Density
- 1.228±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: soluble15mg/mL, clear
- pka
- 13.13±0.20(Predicted)
- form
- powder
- color
- white to beige
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 92427
- Product name
- Bisphenol A (3-chloro-2-hydroxypropyl) (2,3-dihydroxypropyl) ether
- Purity
- analytical standard
- Packaging
- 25mg
- Price
- $240
- Updated
- 2024/03/01
- Product number
- 92427
- Product name
- Bisphenol A (3-chloro-2-hydroxypropyl) (2,3-dihydroxypropyl) ether
- Purity
- analytical standard
- Packaging
- 100mg
- Price
- $712
- Updated
- 2024/03/01
- Product number
- E1380
- Product name
- EPI-001
- Packaging
- 5MG
- Price
- $71
- Updated
- 2024/03/01
- Product number
- E1380
- Product name
- EPI-001
- Packaging
- 25MG
- Price
- $213
- Updated
- 2024/03/01
- Product number
- 16970
- Product name
- EPI-001
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $57
- Updated
- 2024/03/01
BISPHENOL A-(3-CHLORO-2-HYDROXYPROPYL)-& Chemical Properties,Usage,Production
Uses
EPI-001 is a selective peroxisome proliferator-activated receptor-gamma modulator that inhibits androgen receptor expression and activity in prostate cancer. It is a novel androgen receptor antagonists that has the potential for treating prostate cancer.
Definition
ChEBI: Bisphenol A (3-chloro-2-hydroxypropyl) (2,3-dihydroxypropyl) ether is the (3-chloro-2-hydroxypropyl) (2,3-dihydroxypropyl) diether of bisphenol A; a small molecule that inhibits transactivation of the AR amino-terminal domain (NTD). It has a role as an androgen antagonist. It is an organochlorine compound and a diether. It is functionally related to a bisphenol A and a glycerol.
Biological Activity
epi-001 is a small-molecule inhibitor of androgen receptor n-terminal domain. epi-001 could target the amino terminal domain of the ar and inhibit the protein-protein interactions which are necessary for ar transcriptional activity. the androgen receptor (ar) is involved in mediating the actions of male sex steroids. amplification and over-expression of androgen receptor gene may result in hormone-refractory prostate cancer [1].
in vitro
epi-001 inhibited the ligand-dependent argal4 transcriptional activity in lncap cells and the ligand-independent argal4 transcriptional activity in the crpc c4-2 cell line. in a panel of cell lines, epi-001 treatment decreased the mrna expression level of ar protein after 8 and 16 h treatment, such as androgen sensitive pca, crpc, lncap, c4-2, and lapc4 cell line. epi-001 dose-dependently inhibited the pca/crpc cell growth [2].
in vivo
intravenous injection of epi-001 significantly reduced the weight of benign prostates and blocked the growth of prostate cancer xenograft from noncastrated mature mice. epi-001 caused tumor regression of crpc. in male mice bearing lncap xenografts, after treated with epi- 001 by i.v. injection for 2 weeks, the tumor size was less than half of the control group [3].
References
andersen r j, mawji n r, wang j, et al. regression of castrate-recurrent prostate cancer by a small-molecule inhibitor of the amino-terminus domain of the androgen receptor[j]. cancer cell, 2010, 17(6): 535-546.brand l j, olson m e, ravindranathan p, et al. epi-001 is a selective peroxisome proliferator-activated receptor-gamma modulator with inhibitory effects on androgen receptor expression and activity in prostate cancer[j]. oncotarget, 2015, 6(6): 3811.sadar m d. small molecule inhibitors targeting the “achilles' heel” of androgen receptor activity[j]. cancer research, 2011, 71(4): 1208-1213.
BISPHENOL A-(3-CHLORO-2-HYDROXYPROPYL)-& Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from BISPHENOL A-(3-CHLORO-2-HYDROXYPROPYL)-& manufacturers
- Product
- BISPHENOL A-(3-CHLORO-2-HYDROXYPROPYL)-& 227947-06-0
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 95--99%
- Supply Ability
- 1ton
- Release date
- 2020-01-08