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KI16425

Product Name
KI16425
CAS No.
355025-24-0
Chemical Name
KI16425
Synonyms
CS-88;KI-6425;Debio 0719;Ki16425, >=98%;KI16425 USP/EP/BP;KI-16425; KI 16425;Ki16425 (Debio 0719);KI16425;KI-16425; KI 16425;Ki 16425, competitive, potent and reversible antagonist to LPA;Ki 16425, 98%, competitive, potent and reversible antagonist to LPA
CBNumber
CB9497429
Molecular Formula
C23H23ClN2O5S
Formula Weight
474.96
MOL File
355025-24-0.mol
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KI16425 Property

Melting point:
59.5-60.5 °C
Boiling point:
623.7±55.0 °C(Predicted)
Density 
1.353
storage temp. 
-20°C
solubility 
DMSO: 16 mg/mL
form 
solid
pka
4.32±0.10(Predicted)
color 
white
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
HS Code 
29349990
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0971
Product name
Ki 16425
Purity
≥98% (HPLC)
Packaging
5mg
Price
$118
Updated
2024/03/01
Sigma-Aldrich
Product number
SML0971
Product name
Ki 16425
Purity
≥98% (HPLC)
Packaging
25mg
Price
$478
Updated
2024/03/01
Cayman Chemical
Product number
10012659
Product name
Ki 16425
Purity
≥95%
Packaging
1mg
Price
$37
Updated
2024/03/01
Cayman Chemical
Product number
10012659
Product name
Ki 16425
Purity
≥95%
Packaging
5mg
Price
$98
Updated
2024/03/01
Cayman Chemical
Product number
10012659
Product name
Ki 16425
Purity
≥95%
Packaging
10mg
Price
$142
Updated
2024/03/01
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KI16425 Chemical Properties,Usage,Production

Description

Lysophosphatidic acid (LPA) is a bioactive lipid mediator that signals through five distinct G protein-coupled receptors (LPA1-5). Ki16425 is a LPA receptor antagonist with selectivity for LPA1 and LPA3. It exhibits Ki values of 0.34, 6.5, and 0.93 μM for the human LPA1, LPA2, and LPA3 receptors, respectively, as determined by measuring inositol phosphate production in RH7777-transfected cells. Ki1642, at 10 μM, significantly blocks the response of a variety of cancer cell lines to LPA-induced cell migration.

Uses

Ki 16425 has been used as a chemical inhibitor to study the regulation of LPA (lysophosphatidic acid) on LPAR(LPA receptor) subtypes.

Uses

Ki16425 is a competitive, potent and reversible antagonist to LPA1, LPA2 and LPA3.

Definition

ChEBI: 3-[({4-[4-({[1-(2-chlorophenyl)ethoxy]carbonyl}amino)-3-methyl-1,2-oxazol-5-yl]phenyl}methyl)sulfanyl]propanoic acid is a member of the class of isoxazoles that is the carbamate ester obtained by formal condensation of the carboxy group of 1-(2-chlorophenyl)ethyl hydrogen carbonate with the amino group of 3-({[4-(4-amino-3-methyl-1,2-oxazol-5-yl)phenyl]methyl}sulfanyl)propanoic acid. It is a member of isoxazoles, a carbamate ester, a member of monochlorobenzenes, an organic sulfide and a monocarboxylic acid.

Biochem/physiol Actions

Ki 16425 possesses a short-lived inhibitory activity. It has been studied that Ki 16425 is effective in the inhibition of neuropathic pain‐like behaviors.

storage

Store at +4°C

References

[1]. ohta h, sato k, murata n, damirin a, malchinkhuu e, kon j, kimura t, tobo m, yamazaki y, watanabe t, yagi m, sato m, suzuki r, murooka h, sakai t, nishitoba t, im ds, nochi h, tamoto k, tomura h, okajima f. ki16425, a subtype-selective antagonist for edg-family lysophosphatidic acid receptors. mol pharmacol. 2003 oct;64(4):994-1005.
[2]. ruisanchez é, dancs p, kerék m, németh t, faragó b, balogh a, patil r, jennings bl, liliom k, malik ku, smrcka av, tigyi g, benyó z. lysophosphatidic acid induces vasodilation mediated by lpa1 receptors, phospholipase c, and endothelial nitric oxide synthase. faseb j. 2014 feb;28(2):880-90.
[3]. su sc, hu x, kenney pa, merrill mm, babaian kn, zhang xy, maity t, yang sf, lin x, wood cg. autotaxin-lysophosphatidic acid signaling axis mediates tumorigenesis and development of acquired resistance to sunitinib in renal cell carcinoma. clin cancer res. 2013 dec 1;19(23):6461-72.
[4]. david m, sahay d, mege f, descotes f, leblanc r, ribeiro j, clézardin p, peyruchaud o. identification of heparin-binding egf-like growth factor (hb-egf) as a biomarker for lysophosphatidic acid receptor type 1 (lpa1) activation in human breast and prostate cancers. plos one. 2014 may 14;9(5):e97771.

KI16425 Preparation Products And Raw materials

Raw materials

Preparation Products

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KI16425 Suppliers

China 84 India 2 Switzerland 1 United Kingdom 2 United States 18 Global 107
AdooQ BioScience, LLC
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Cckinase, Inc.
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355025-24-0, KI16425Related Search:

Tofacitinib citrate 42-(Dimethylphosphinate)rapamycin MG-132 PD 98059 LY 2157299 Olaparib 3,5-DIMETHYL-4-ISOXAZOLEMETHANAMINE KI16425 N-(4-ISOXAZOLYL)FORMAMIDE 4-ISOXAZOLAMINE

  • CS-88
  • KI-16425; KI 16425
  • 3-[[[4-[4-[[[1-(2-chlorophenyl)ethoxy]carbonyl]amino]-3-methyl-5-isoxazoly]phenyl]methyl]thio]-propanoic acid
  • 3-[[[4-[4-[[[1-(2-Chlorophenyl)ethoxy]carbonyl]amino]-3-methyl-5-isoxazolyl]phenyl]methyl]thio]propanoic acid
  • KI-6425
  • 3-(4-(4-((1-(2-chlorophenyl)ethoxy)carbonyl)-3-methylisoxazol-5-yl)benzylthio)propanoic acid
  • Ki16425, >=98%
  • KI16425;KI-16425; KI 16425
  • 3-[[4-[4-[1-(2-chlorophenyl)ethoxycarbonylamino]-3-methyl-isoxazol-5-yl]phenyl]methylsulfanyl]propanoic acid
  • 3-((4-(4-(((1-(2-Chlorophenyl)ethoxy)carbonyl)amino)-3-methylisoxazol-5-yl)benzyl)thio)propano
  • Ki 16425, 98%, competitive, potent and reversible antagonist to LPA
  • Debio 0719
  • Propanoic acid, 3-[[[4-[4-[[[1-(2-chlorophenyl)ethoxy]carbonyl]amino]-3-methyl-5-isoxazolyl]phenyl]methyl]thio]-
  • KI16425 USP/EP/BP
  • Ki16425 (Debio 0719)
  • Ki 16425, competitive, potent and reversible antagonist to LPA
  • 355025-24-0
  • Inhibitors