3-(Dimethylamino)-1-(pyridine-2-yl)prop-2-en-1-one
Synthesis- Product Name
- 3-(Dimethylamino)-1-(pyridine-2-yl)prop-2-en-1-one
- CAS No.
- 66521-54-8
- Chemical Name
- 3-(Dimethylamino)-1-(pyridine-2-yl)prop-2-en-1-one
- Synonyms
- 5C-070;511676_ALDRICH;2-[3-(Dimethylamino)acryloyl]pyridine;3-(DIMETHYLAMINO)-1-(2-PYRIDYL)-2-PROPE&;3-(DIMETHYLAMINO)-1-(2-PYRIDYL)-2-PROPE&3-dimethylamino-1-(2-pyridyl)prop-2-en-1-one;1-(2-Pyridyl)-3-dimethylamino-2-propen-1-one;(E)-3-dimethylamino-1-(2-pyridyl)prop-2-en-1-one;3-(Dimethylamino)-1-(pyridin-2-yl)prop-2-en-1-one;3-(Dimethylamino)-1-(2-pyridyl)-2-propen-1-one 95%
- CBNumber
- CB9499498
- Molecular Formula
- C10H12N2O
- Formula Weight
- 176.22
- MOL File
- 66521-54-8.mol
3-(Dimethylamino)-1-(pyridine-2-yl)prop-2-en-1-one Property
- Melting point:
- 126-130 °C(lit.)
- Boiling point:
- 281.4±36.0 °C(Predicted)
- Density
- 1.07
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 6.25±0.70(Predicted)
- Appearance
- Yellow to brown Solid
- InChI
- 1S/C10H12N2O/c1-12(2)8-6-10(13)9-5-3-4-7-11-9/h3-8H,1-2H3/b8-6+
- InChIKey
- BWERGHWJEBQNQV-SOFGYWHQSA-N
- SMILES
- CN(C)\C=C\C(=O)c1ccccn1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 511676
- Product name
- 3-(Dimethylamino)-1-(2-pyridyl)-2-propen-1-one
- Purity
- 95%
- Packaging
- 25g
- Price
- $93
- Updated
- 2023/06/20
- Product number
- D495963
- Product name
- (E)-3-(Dimethylamino)-1-(pyridin-2-yl)prop-2-en-1-one
- Packaging
- 5g
- Price
- $65
- Updated
- 2021/12/16
- Product number
- FD124317
- Product name
- (2E)-3-(Dimethylamino)-1-pyridin-2-ylprop-2-en-1-one
- Packaging
- 500mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 024678
- Product name
- 3-Dimethylamino-1-pyridin-2-yl-propenone
- Purity
- 97%
- Packaging
- 25g
- Price
- $78
- Updated
- 2021/12/16
- Product number
- FD124317
- Product name
- (2E)-3-(Dimethylamino)-1-pyridin-2-ylprop-2-en-1-one
- Packaging
- 1g
- Price
- $128
- Updated
- 2021/12/16
3-(Dimethylamino)-1-(pyridine-2-yl)prop-2-en-1-one Chemical Properties,Usage,Production
Synthesis
3-(Dimethylamino)-1-(pyridine-2-yl)prop-2-en-1-one was synthesised based on the literature. The reaction of (2g, 16.5mmol) of 2-acetylpyridine and DMF dimethyl acetal(7.84g) were suspended in 11ml of xylene and stir this reaction mixture for 16h at 110℃. Into the resulting mixture 10 ml of hexane added yellow colour precipitate was formed and allows stirring for 20min at 3℃. Resulting mixture was filtered and dried in vacuum to get a yellow colour powder.
Uses
3-(Dimethylamino)-1-(2-pyridyl)-2-propen-1-one may be used in the preparation of the 5-(heteroaryl)isoxazole derivatives, 5-(2-pyridyl)isoxazole and 3-methyl-5-(2-pyridyl)isoxazole. It may also be used to synthesize 7-(2-pyridyl)-1,2,4-triazolo[1,5-a]pyrimidine.
General Description
3-(Dimethylamino)-1-(2-pyridyl)-2-propen-1-one (1-(2′-Pyridyl)-3-dimethylamino-2-propen-1-one), an enaminone, is a hemilabile hybrid ligand. The preparation of cationic mononuclear rhodium(I) or iridium(I) complexes containing 3-(dimethylamino)-1-(2-pyridyl)-2-propen-1-one have been reported.
References
[1] Molecules, 2007, vol. 12, # 8, p. 2061 - 2079
[2] European Journal of Organic Chemistry, 2012, # 32, p. 6407 - 6413,7
[3] Synthetic Communications, 1993, vol. 23, # 13, p. 1897 - 1903
[4] Organic Preparations and Procedures International, 1997, vol. 29, # 3, p. 285 - 292
[5] Journal of Chemical Research, Miniprint, 1997, # 3, p. 601 - 615
3-(Dimethylamino)-1-(pyridine-2-yl)prop-2-en-1-one Preparation Products And Raw materials
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