Prothioconazole
- Product Name
- Prothioconazole
- CAS No.
- 178928-70-6
- Chemical Name
- Prothioconazole
- Synonyms
- 2-[2-(1-chlorocyclopropyl)-3-(2-chlorophenyl)-2-hydroxypropyl]-1,2-dihydro-3H-1,2,4-triazole-3-thione;jau 6476;HSDB7893;HSDB 7893;HSDB-7893;Prothioconzole;PROTHIOCONAZOLE;C sulfur bacteria;Thiazole propionate;Prothioconazole Solution
- CBNumber
- CB9500604
- Molecular Formula
- C14H15Cl2N3OS
- Formula Weight
- 344.26
- MOL File
- 178928-70-6.mol
Prothioconazole Property
- Melting point:
- 139.1-144.5°
- Boiling point:
- 486.7±55.0 °C(Predicted)
- Density
- 1.50±0.1 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- DMSO (Slightly), Methanol (Slightly)
- pka
- 6.9(at 25℃)
- form
- Solid
- color
- White to light yellow
- InChI
- InChI=1S/C14H15Cl2N3OS/c15-11-4-2-1-3-10(11)7-14(20,13(16)5-6-13)8-19-12(21)17-9-18-19/h1-4,9,20H,5-8H2,(H,17,18,21)
- InChIKey
- MNHVNIJQQRJYDH-UHFFFAOYSA-N
- SMILES
- N1C=NC(=S)N1CC(C1(Cl)CC1)(O)CC1=CC=CC=C1Cl
- LogP
- 1.770 (est)
- EPA Substance Registry System
- 3H-1,2,4-Triazole-3-thione, 2-[2-(1-chlorocyclopropyl)-3-(2-chlorophenyl)-2-hydroxypropyl]-1,2-dihydro- (178928-70-6)
Safety
- Hazard Codes
- Xi,N
- Risk Statements
- 51/53
- Safety Statements
- 61
- RIDADR
- UN3077 9/PG 3
- WGK Germany
- 2
- HS Code
- 2933998090
- Hazardous Substances Data
- 178928-70-6(Hazardous Substances Data)
- Toxicity
- LD50 in rats (mg/kg): > 6200 orally; > 2000 dermally; LC50 in rats (mg/m3): > 4990 by inhalation; LC50 (96 hr) in rainbow trout: 1.83 mg/l (Mauler-Machnik)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H410Very toxic to aquatic life with long lasting effects
- Precautionary statements
-
P273Avoid release to the environment.
P391Collect spillage. Hazardous to the aquatic environment
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 34232
- Product name
- Prothioconazole
- Purity
- PESTANAL
- Packaging
- 100mg
- Price
- $279
- Updated
- 2025/07/31
- Product number
- P838830
- Product name
- Prothioconazole
- Packaging
- 1g
- Price
- $275
- Updated
- 2021/12/16
- Product number
- P838830
- Product name
- Prothioconazole
- Packaging
- 50mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- 3283BB
- Product name
- Prothioconazole
- Packaging
- 25g
- Price
- $197
- Updated
- 2021/12/16
- Product number
- 8H67-5-27
- Product name
- 2-[2-(1-Chlorocyclopropyl)-3-(2-chlorophenyl)-2-hydroxypropyl]-1,2-dihydro-3H-1,2,4-triazole-3-thione
- Purity
- 95.0%
- Packaging
- 25g
- Price
- $240
- Updated
- 2021/12/16
Prothioconazole Chemical Properties,Usage,Production
Uses
Prothioconazole is an antifungal metabolite used in agricultural fungicides and herbicides.
Definition
ChEBI: 2-[2-(1-chlorocyclopropyl)-3-(2-chlorophenyl)-2-hydroxypropyl]-1,2-dihydro-1,2,4-triazole-3-thione is a member of the class of triazoles that is 1,2,4-triazole-3-thione substituted at position 2 by a 2-(1-chlorocyclopropyl)-3-(2-chlorophenyl)-2-hydroxypropyl group. It is a member of monochlorobenzenes, a member of triazoles, a tertiary alcohol, a member of cyclopropanes and a thiocarbonyl compound.
Synthesis
222408-90-4
178928-70-6
The general procedure for the synthesis of 2-(2-(1-chlorocyclopropyl)-3-(2-chlorophenyl)-2-hydroxypropyl)-1,2,4-triazolidine-3-thione from 2-(2-(1-chlorocyclopropyl)-3-(2-chlorophenyl)-2-hydroxypropyl)-1H-1,2,4-triazolidine-3(2H)-thione was carried out as follows: 2-(1-chlorocyclopropan-1-yl)-1-(2- chlorophenyl)-2-hydroxy-3-(1,2,4-triazolidine-5-thioxo-1-)propane IV (34.6 g, 0.10 mol) was dissolved in acetone (50 mL), followed by slow dropwise addition of hydrogen peroxide (0.15 mmol). The reaction mixture was stirred at 25°C for 2 hours. Upon completion of the reaction, sodium sulfite (6.5 g) was added to the reaction solution and stirring was continued for 1 h at room temperature and the end point of the reaction was detected using potassium iodide starch test paper. Water (50 mL) was added to the reaction system, followed by extraction with ethyl acetate (50 mL each time, three times). The organic phases were combined, dried with anhydrous sodium sulfate and concentrated under reduced pressure to give the crude product (35 g, 90% purity). The crude product was recrystallized from toluene to give prothioconazole (31.6 g) as a white solid in 98% yield and 90% purity.
References
[1] Patent: CN106986838, 2017, A. Location in patent: Paragraph 0055; 0056; 0057; 0058; 0061
Prothioconazole Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Prothioconazole manufacturers
- Product
- prothioconazole 178928-70-6
- Price
- US $0.00/kg
- Min. Order
- 100kg
- Purity
- 98
- Supply Ability
- 100
- Release date
- 2025-09-28
- Product
- Prothioconazole 178928-70-6
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-11-28
- Product
- Prothioconazole 178928-70-6
- Price
- US $30.00-10.00/KG
- Min. Order
- 50KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2024-10-25