4-AMINO-2-CHLOROPYRIDINE, N-BOC PROTECTED 98
- Product Name
- 4-AMINO-2-CHLOROPYRIDINE, N-BOC PROTECTED 98
- CAS No.
- 234108-73-7
- Chemical Name
- 4-AMINO-2-CHLOROPYRIDINE, N-BOC PROTECTED 98
- Synonyms
- 4-(Boc-aMino)-2-chloropyr...;N-Boc-2-chloro-4-pyridinamine;4-(Boc-amino)-2-chloropyridine;N-BOC PROTECTED 4-AMINO-2-CHLOROPYRIDINE;tert-Butyl 2-chloropyridin-4-ylcarbamate;4-Amino-2-chloropyridine, 4-BOC protected;ert-butylN-(2-chloropyridin-4-yl)carbamate;tert-butyl N-(2-chloropyridin-4-yl)carbamate;4-AMINO-2-CHLOROPYRIDINE, N-BOC PROTECTED 98;4-Amino-2-chloropyridine, N-BOC protected 98%
- CBNumber
- CB9501333
- Molecular Formula
- C10H13ClN2O2
- Formula Weight
- 228.68
- MOL File
- 234108-73-7.mol
4-AMINO-2-CHLOROPYRIDINE, N-BOC PROTECTED 98 Property
- Melting point:
- 173-175
- Boiling point:
- 282.2±25.0 °C(Predicted)
- Density
- 1.245±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- pka
- 11.97±0.70(Predicted)
- Appearance
- White to off-white Solid
Safety
- Hazard Codes
- Xi
- Hazard Note
- Irritant
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- B692605
- Product name
- tert-Butyl(2-Chloropyridin-4-yl)carbamate
- Packaging
- 25g
- Price
- $1385
- Updated
- 2021/12/16
- Product number
- 4H56-5-J5
- Product name
- 4-Amino-2-chloropyridine, 4-Boc protected
- Purity
- 98%
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 081250
- Product name
- tert-Butyl 2-chloropyridin-4-ylcarbamate
- Purity
- 97%
- Packaging
- 1g
- Price
- $139
- Updated
- 2021/12/16
- Product number
- 4H56-5-J5
- Product name
- 4-Amino-2-chloropyridine, 4-Boc protected
- Purity
- 98%
- Packaging
- 5G
- Price
- $260
- Updated
- 2021/12/16
- Product number
- HCH0022772
- Product name
- 4-(BOC-AMINO)-2-CHLOROPYRIDINE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $667.73
- Updated
- 2021/12/16
4-AMINO-2-CHLOROPYRIDINE, N-BOC PROTECTED 98 Chemical Properties,Usage,Production
Uses
tert-Butyl (2-Chloropyridin-4-yl)carbamate is a reactant in the preparation of inter-domain stabilizers for allosteric Akt inhibitors.
Synthesis
14432-12-3
24424-99-5
234108-73-7
General procedure for the synthesis of tert-butyl 2-chloropyridine-4-carbamate from 2-chloro-4-aminopyridine and di-tert-butyl dicarbonate: In the presence of 95 mg of 4-dimethylaminopyridine (DMAP), 1.69 g (7.78 mmol, 1 eq.) of di-tert-butyl dicarbonate was dissolved in 50 mL of dichloromethane, and slowly added to a 30 mL solution of dichloromethane containing 1 g (7.78 mmol, 1 eq.) of 2-chloro-4-aminopyridine and 1.19 mL (1.19 mmol, 1.1 eq.) of triethylamine in 30 mL of dichloromethane. The reaction mixture was stirred overnight at room temperature. Upon completion of the reaction, the reaction was quenched by the addition of 100 mL of water and subsequently extracted with dichloromethane. The organic phases were combined and dried over anhydrous sodium sulfate. After evaporation of the solvent under reduced pressure, the residue was purified by silica gel column chromatography (eluent ratio varied from 70/30 to 50/50 heptane/ethyl acetate gradient). The resulting oil was crystallized from pentane to give 1.40 g tert-butyl 2-chloropyridine-4-carbamate in 80% yield.
References
[1] Patent: WO2006/53791, 2006, A2. Location in patent: Page/Page column 49-50
[2] Tetrahedron Letters, 2014, vol. 55, # 49, p. 6734 - 6737
[3] Patent: WO2005/33072, 2005, A2. Location in patent: Page/Page column 26
[4] Patent: WO2004/43926, 2004, A1. Location in patent: Page 161
[5] Patent: US2004/102450, 2004, A1. Location in patent: Page/Page column 100
4-AMINO-2-CHLOROPYRIDINE, N-BOC PROTECTED 98 Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-AMINO-2-CHLOROPYRIDINE, N-BOC PROTECTED 98 manufacturers
- Product
- 4-AMINO-2-CHLOROPYRIDINE, N-BOC PROTECTED 98 234108-73-7
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 200KG
- Release date
- 2018-12-23