Diphemanil Methylsulfate

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Diphemanil Methylsulfate

Product Name: Diphemanil Methylsulfate
CAS No.: 62-97-5
Chemical Name: Diphemanil Methylsulfate
Synonyms: prantal;variton;Talpran;demotil;nivelona;diphemanil;diphenatil;vagophemanil;diphenmethanil;Diphemanil mesylate
CBNumber: CB9505795
Molecular Formula: C20H24N.CH3O4S
Formula Weight: 389.51
MOL File: 62-97-5.mol

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Diphemanil Methylsulfate Property

Melting point:: 194-195℃
storage temp.: Inert atmosphere,Store in freezer, under -20°C
Water Solubility: Soluble in water
solubility: : 16.67 mg/mL (42.80 mM; Need ultrasonic)
form: powder to crystal
color: White to Almost white
Stability:: Hygroscopic

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Safety

HS Code: 2933.39.4100
Toxicity: LD50 in rats, mice, guinea pigs (mg/kg): 1107, 64, 404 orally (Margolin)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

TCI Chemical

Product number: D5623
Product name: Diphemanil Methylsulfate
Packaging: 250MG
Price: $221
Updated: 2024/03/01

TCI Chemical

Product number: D5623
Product name: Diphemanil Methylsulfate
Packaging: 1G
Price: $648
Updated: 2024/03/01

Cayman Chemical

Product number: 30090
Product name: Diphemanil (methyl sulfate)
Packaging: 25mg
Price: $68
Updated: 2024/03/01

Cayman Chemical

Product number: 30090
Product name: Diphemanil (methyl sulfate)
Packaging: 50mg
Price: $89
Updated: 2024/03/01

Cayman Chemical

Product number: 30090
Product name: Diphemanil (methyl sulfate)
Packaging: 100mg
Price: $149
Updated: 2024/03/01

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Diphemanil Methylsulfate Chemical Properties,Usage,Production

Description

Diphemanil is a quaternary ammonium anticholinergic agent. It induces relaxation of isolated guinea pig trachea strips precontracted with methacholine (EC₅₀ = 0.12 nM). Diphemanil reverses increases in lung resistance and decreases in dynamic lung compliance induced by the non-selective acetylcholine receptor agonist carbachol (carbamoylcholine; ) in vagotomized cats (ED₅₀s = 17.5 and 19.3 μg/kg, respectively). It reduces salivation induced by the muscarinic acetylcholine receptor agonist pilocarpine in mice when administered subcutaneously at doses ranging from 1.25 to 10 mg/kg.

Originator

Pranta,Schering,US,1952

Uses

Diphemanil Methosulfate is an anticholinergic agent; a synthetic quaternary ammonium compound with anitmuscarinic properties used in the treatment of Frey''s syndrome and is used as a parasympatholytic bronchodilator agent.

Uses

Bronchodilatator;Anticholinergic

Definition

ChEBI: The alkene resulting from the formal Wittig olefination of benzophenone and 1,1-dimethyl-4-bromopiperidinium methylsulfate. A quaternary ammonium anticholinergic, it binds muscarinic acetycholine receptors and thereby decreases secretory excretion of stoma h acids, saliva and sweat, It is used topically in the treatment of hyperhidorsis (excessive sweating).

Manufacturing Process

(A) Preparation of diphenyl-(N-Methyl-4-Piperidyl)carbinol: to a Grignard solution prepared from 4.9 grams of magnesium, 100 cc of ether and 31.4 grams of dry
omobenzene is added 18.5 grams of 4-benzoyl-Nmethylpiperidine in 200 cc of dry ether. The reaction mixture is heated with stirring for 4 hours on the steam bath and then decomposed. The organic layer is separated and the aqueous layer extracted with benzene. The combined organic extracts are concentrated and the residue, diphenyl-(Nmethyl-4-piperidyl)carbinol, recrystallized from benzene-petroleum ether, MP 130-131°C. The Grignard complex may also be decomposed with ice and hydrochloric acid and the insoluble hydrochloride of the carbinol isolated directly.
(B) Preparation of diphenyl-(N-Methyl-4-Piperidylidene)methane: the carbinol can be dehydrated with 60% sulfuric acid. In general, to one part of the carbinol there is added 10 parts of 60% sulfuric acid. The mixture after heating for 6 hours is poured onto cracked ice, the solution made alkaline with dilute sodium hydroxide and the oily basic layer extracted with ether. The ether extracts after washing with water are dried over sodium sulfate, and after removing the ether, the residue is distilled in vacuo, MP 52°-53°C.
(C) Preparation of Final Product: The product from (B) is reacted with dimethyl sulfate in benzene to give the final product, MP 196°-197°C.

brand name

Prantal (Schering).

Therapeutic Function

Spasmolytic

General Description

Diphemanil methylsulfate,4-(diphenylmethylene)-1,1-dimethylpiperidiniummethylsulfate (Prantal), or diphemanil methylsulfate is apotent cholinergic blocking agent. In the usual dosagerange, it acts as an effective parasympatholytic by blockingnerve impulses at the parasympathetic ganglia, but it doesnot invoke a sympathetic ganglionic blockade. It is claimedto be highly specific in its action on those innervations thatactivate gastric secretion and GI motility. Although thisdrug can produce atropine-like side effects, they rarelyoccur at recommended doses. The highly specific nature ofits action on gastric functions makes the drug useful inthe treatment of peptic ulcer, and its lack of atropine-likeeffects makes its use much less distressing than other antispasmodicdrugs. In addition to its action in decreasinggastric hypermotility, diphemanil methylsulfate is valuablein hyperhidrosis in low doses (50 mg twice daily) or topically.The drug is not well absorbed from the GI tract,particularly in the presence of food, and should be administeredbetween meals. The methylsulfate salt was chosen asthe best, because the chloride is hygroscopic and the bromideand iodide ions have exhibited toxic manifestations inclinical use.

Diphemanil Methylsulfate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Diphemanil Methylsulfate manufacturers

Hong Kong Tiansheng New Material Trading Co., Ltd

Product: Diphenmanil (methylsulfate) 62-97-5
Price: US $12.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2021-09-24

Hong Kong Tiansheng New Material Trading Co., Ltd

Product: Diphenmanil (methylsulfate) 62-97-5
Price: US $12.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10kg
Release date: 2021-09-24

62-97-5, Diphemanil MethylsulfateRelated Search:

1,4-PHENYLENE DIISOTHIOCYANATE Benzenesulfonic acid 4'-Methylthioacetophenone Tacrolimus Selumetinib Danusertib Bosutinib Panobinostat Entinostat Diphemanil Methylsulfate TETRAMETHYLAMMONIUM METHYL SULFATE 4-(DIPHENYLMETHYLENE)PIPERIDINE

nivelona

p-(alpha-phenylbenzylidene)-1,1-dimethylpiperidiniummethylsulfate

prantal

prantalmethylsulfate

vagophemanil

vagophemanilmethylsulfate

variton

DIPHEMANIL METHYLSULFATE (500 MG) DISCON-TINUED

4-(diphenylmethylene)-1,1-dimethyl-piperidiniumethylsulfate

n,n-dimethyl-4-piperidylidene-1,1-diphenylmethanemethylsulfate

Diphemanil mesylate

diphemanil metilsulfate

Diphenmanil methosulfate

Talpran

4-benzhydrylidene-1,1-dimethyl-piperidin-1-ium

4-benzhydrylidene-1,1-dimethylpiperidin-1-ium

Piperidinium, 4-(diphenylmethylene)-1,1-dimethyl-, methyl sulfate

Piperidinium, 4-(diphenylmethylene)-1,1-dimethyl-, methyl sulfate (1:1)

DIPHEMANIL METHYLSULFAT

4-(diphenylmethylene)-1,1-dimethylpiperidiniummethylsulfate

demotil

diphemanil

diphemanilmethylsulfate

diphenatil

diphenmanilmethylsulfate

diphenmethanil

diphenmethanilmethylsulfate

4-(Diphenylmethylene)-1,1-dimethylpiperidin-1-ium Methyl Sulfate

Diphemanil Methylsulfate USP/EP/BP

iphemanilmethylsulfate

62-97-5

62-97-6

C20H24NCH3O4S

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