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RIPK1-IN-7

Product Name
RIPK1-IN-7
CAS No.
2300982-44-7
Chemical Name
RIPK1-IN-7
Synonyms
RIPK1-IN-7;RIPK1 inhibitor 7;RIPK1-IN-7, 10 mM in DMSO;1-(5-(4-Amino-7-ethyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)indolin-1-yl)-2-(3-(trifluoromethoxy)phenyl)ethan-1-one;Ethanone, 1-[5-(4-amino-7-ethyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2,3-dihydro-1H-indol-1-yl]-2-[3-(trifluoromethoxy)phenyl]-;RIPK-1-IN-7,inhibit,TrkA,Mer,Receptor-interacting protein kinases,Flt4,Axl,TrkB,Inhibitor,RIP kinase,RIPK,TrkC,RIPK1 IN 7,RIPK1IN7,HRI
CBNumber
CB95419833
Molecular Formula
C25H22F3N5O2
Formula Weight
481.47
MOL File
2300982-44-7.mol
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RIPK1-IN-7 Property

Boiling point:
724.8±60.0 °C(Predicted)
Density 
1.42±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO: 62.5 mg/mL (129.81 mM); Water: < 0.1 mg/mL (insoluble)
form 
Solid
pka
5.76±0.30(Predicted)
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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RIPK1-IN-7 Chemical Properties,Usage,Production

Biological Activity

RIPK1-IN-7 is a receptor-interacting protein kinase 1 (RIPK1) inhibitor with a Kd of 4 nM and an IC50 of 11 nM. RIPK1-IN-7 has good anti-metastatic activity in an experimental B16 melanoma lung metastasis model.

in vitro

RIPK1-IN-7 shows potent cell protection effect in the TSZ-induced HT29 cell necroptosis model with an EC 50 of 2nM.
It displays considerable activity against several other kinases, such as Flt4, TrkA, TrkB, TrkC, Axl, HRI, Mer, and MAP4K5 with IC 50 s of 20, 26, 8, 7, 35, 26, 29, and 27 nM, respectively.

target

IC50: 11 nM (RIPK1)
Kd: 4 nM (RIPK1)

RIPK1-IN-7 Preparation Products And Raw materials

Raw materials

Preparation Products

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RIPK1-IN-7 Suppliers

China 18 United States 3 Global 21
TargetMol Chemicals Inc.
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+1-781-999-5354 +1-00000000000
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marketing@targetmol.com
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United States
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TargetMol Chemicals Inc.
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support@targetmol.com
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United States
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MedChemExpress
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2300982-44-7, RIPK1-IN-7Related Search:


  • RIPK1-IN-7
  • RIPK1 inhibitor 7
  • Ethanone, 1-[5-(4-amino-7-ethyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2,3-dihydro-1H-indol-1-yl]-2-[3-(trifluoromethoxy)phenyl]-
  • RIPK-1-IN-7,inhibit,TrkA,Mer,Receptor-interacting protein kinases,Flt4,Axl,TrkB,Inhibitor,RIP kinase,RIPK,TrkC,RIPK1 IN 7,RIPK1IN7,HRI
  • 1-(5-(4-Amino-7-ethyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)indolin-1-yl)-2-(3-(trifluoromethoxy)phenyl)ethan-1-one
  • RIPK1-IN-7, 10 mM in DMSO
  • 2300982-44-7