UBCS039

Product Name: UBCS039
CAS No.: 358721-70-7
Chemical Name: UBCS039
Synonyms: UBCS039;4-(Pyridin-3-yl)-4,5-dihydropyrrolo[1,2-a]quinoxaline;Pyrrolo[1,2-a]quinoxaline, 4,5-dihydro-4-(3-pyridinyl)-;Autophagy,UBCS039,UBCS 039,inhibit,Sirtuin,Inhibitor,UBCS-039
CBNumber: CB95419868
Molecular Formula: C16H13N3
Formula Weight: 247.29
MOL File: 358721-70-7.mol

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UBCS039 Property

Boiling point:: 453.9±45.0 °C(Predicted)
Density: 1.25±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO : 125 mg/mL (505.48 mM)
pka: 4.66±0.12(Predicted)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0086992
Product name: UBCS039
Purity: 98.13%
Packaging: 5mg
Price: $180
Updated: 2021/12/16

ChemScene

Product number: CS-0086992
Product name: UBCS039
Purity: 98.13%
Packaging: 10mg
Price: $280
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: BRS0009227
Product name: UBCS-039
Purity: 95.00%
Packaging: 5MG
Price: $458.62
Updated: 2021/12/16

ChemScene

Product number: CS-0086992
Product name: UBCS039
Purity: 98.13%
Packaging: 25mg
Price: $570
Updated: 2021/12/16

ChemScene

Product number: CS-0086992
Product name: UBCS039
Purity: 98.13%
Packaging: 50mg
Price: $960
Updated: 2021/12/16

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UBCS039 Chemical Properties,Usage,Production

Biological Activity

UBCS039, the first synthetic SIRT6 activator with EC50 of 38 μM, induces time-dependent activation of autophagy in multiple human tumor cell lines.

in vitro

UBCS039 (75 μM, 48 or 72 hours) induces deacetylation of SIRT6-targeted histone H3 sites in human cancer cells. It leads to autophagosome accumulation in human cancer cells.UBCS039 induces autophagy via AMP-activated protein kinase (AMPK) signaling pathway activation.

Western Blot Analysis

Cell Line:	Human H1299 cells.
Concentration:	75 μM.
Incubation Time:	48 and 72 hours.
Result:	Induced deacetylation of SIRT6-targeted histone H3 sites in human H1299 cells.

Cell Proliferation Assay

Cell Line:	Human H1299 cells.
Concentration:	100 μM.
Incubation Time:	48 and 72 hours.
Result:	Led to a strong decrease of cell proliferation in a dose-dependent manner when compared with control or DMSO-treated cells, starting from day 3 of growth (48 h after treatment) in both H1299 and HeLa cell lines.

target

Target	Value
SIRT6 (Cell-free assay)	38 μM(EC50)

UBCS039 Preparation Products And Raw materials

Raw materials

Preparation Products

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UBCS039 Suppliers

China 42 United States 3 Global 45

Sichuan Wei Keqi Biological Technology Co., Ltd.

Tel: 028-81700200 18116577057
Fax: 028-81705658
Email: 3003855609@qq.com
Country: China
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Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4153
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Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9709
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Tianjin Kailiqi Biotechnology Co., Ltd.

Tel: 15076683720
Fax: 022-23754520
Email: klq@cw-bio.com
Country: China
ProdList: 3501
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Shanghai Rechem science Co., Ltd.

Tel: 21-31433387 15618786686
Fax: QQ:1369748377
Email: sales@rechemscience.com
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Shanghai Chaolan Chemical Technology Center

Tel: QQ:65489617 15618227136
Fax: 21-5161 9052
Email: info@SuperLan-chem.com
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Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 18892239720
Fax: 010-60605840
Email: psaitong@jm-bio.com
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Fan De(Beijing) Biotechnology Co., Ltd.

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Email: liming@bio-fount.com
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Henan Alpha Chemical Co., Ltd.

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Fax: QQ：3002694073
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Shanghai Dongyang Biotechnology Co., Ltd.

Tel: 0512-0512-13601744364 13601744364
Email: chemsharker@126.com
Country: China
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358721-70-7, UBCS039Related Search:

UBCS039

Pyrrolo[1,2-a]quinoxaline, 4,5-dihydro-4-(3-pyridinyl)-

4-(Pyridin-3-yl)-4,5-dihydropyrrolo[1,2-a]quinoxaline

Autophagy,UBCS039,UBCS 039,inhibit,Sirtuin,Inhibitor,UBCS-039

358721-70-7