UBCS039
- Product Name
- UBCS039
- CAS No.
- 358721-70-7
- Chemical Name
- UBCS039
- Synonyms
- UBCS039;4-(Pyridin-3-yl)-4,5-dihydropyrrolo[1,2-a]quinoxaline;Pyrrolo[1,2-a]quinoxaline, 4,5-dihydro-4-(3-pyridinyl)-;Autophagy,UBCS039,UBCS 039,inhibit,Sirtuin,Inhibitor,UBCS-039
- CBNumber
- CB95419868
- Molecular Formula
- C16H13N3
- Formula Weight
- 247.29
- MOL File
- 358721-70-7.mol
UBCS039 Property
- Boiling point:
- 453.9±45.0 °C(Predicted)
- Density
- 1.25±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO : 125 mg/mL (505.48 mM)
- pka
- 4.66±0.12(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- CS-0086992
- Product name
- UBCS039
- Purity
- 98.13%
- Packaging
- 5mg
- Price
- $180
- Updated
- 2021/12/16
- Product number
- CS-0086992
- Product name
- UBCS039
- Purity
- 98.13%
- Packaging
- 10mg
- Price
- $280
- Updated
- 2021/12/16
- Product number
- BRS0009227
- Product name
- UBCS-039
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $458.62
- Updated
- 2021/12/16
- Product number
- CS-0086992
- Product name
- UBCS039
- Purity
- 98.13%
- Packaging
- 25mg
- Price
- $570
- Updated
- 2021/12/16
- Product number
- CS-0086992
- Product name
- UBCS039
- Purity
- 98.13%
- Packaging
- 50mg
- Price
- $960
- Updated
- 2021/12/16
UBCS039 Chemical Properties,Usage,Production
Biological Activity
UBCS039, the first synthetic SIRT6 activator with EC50 of 38 μM, induces time-dependent activation of autophagy in multiple human tumor cell lines.
in vitro
UBCS039 (75 μM, 48 or 72 hours) induces deacetylation of SIRT6-targeted histone H3 sites in human cancer cells. It leads to autophagosome accumulation in human cancer cells.UBCS039 induces autophagy via AMP-activated protein kinase (AMPK) signaling pathway activation.
Western Blot Analysis
| Cell Line: | Human H1299 cells. |
| Concentration: | 75 μM. |
| Incubation Time: | 48 and 72 hours. |
| Result: | Induced deacetylation of SIRT6-targeted histone H3 sites in human H1299 cells. |
Cell Proliferation Assay
| Cell Line: | Human H1299 cells. |
| Concentration: | 100 μM. |
| Incubation Time: | 48 and 72 hours. |
| Result: | Led to a strong decrease of cell proliferation in a dose-dependent manner when compared with control or DMSO-treated cells, starting from day 3 of growth (48 h after treatment) in both H1299 and HeLa cell lines. |
target
| Target | Value |
| SIRT6 (Cell-free assay) | 38 μM(EC50) |
UBCS039 Preparation Products And Raw materials
Raw materials
Preparation Products
UBCS039 Suppliers
- Tel
- +1-833-552-7181
- sales@aladdinsci.com
- Country
- United States
- ProdList
- 57511
- Advantage
- 58
- Tel
- +1-781-999-5354
- support@targetmol.com
- Country
- United States
- ProdList
- 19973
- Advantage
- 58