Smurf1 Antibody
Source Reactivity Background References- Product Name
- Smurf1 Antibody
- Chemical Name
- Smurf1 Antibody
- Synonyms
- Smurf1 Antibody
- CBNumber
- CB95531155
- Formula Weight
- 0
- MOL File
- Mol file
N-Bromosuccinimide Price
- Product number
- orb1380
- Product name
- SMURF1 antibody
- Purity
- Affinity purified by Protein A
- Packaging
- 100μg
- Price
- $421.6
- Updated
- 2021/12/16
- Product number
- orb33679
- Product name
- SMURF1 antibody
- Purity
- Affinity purified
- Packaging
- 400μl
- Price
- $525.3
- Updated
- 2021/12/16
- Product number
- orb163698
- Product name
- SMURF1 antibody
- Purity
- Peptide Affinity purified
- Packaging
- 400μl
- Price
- $525.3
- Updated
- 2021/12/16
- Product number
- orb33678
- Product name
- SMURF1 antibody
- Purity
- Purified.
- Packaging
- 400μl
- Price
- $525.3
- Updated
- 2021/12/16
- Product number
- orb1380
- Product name
- SMURF1 antibody
- Purity
- Affinity purified by Protein A
- Packaging
- 200μg
- Price
- $673.2
- Updated
- 2021/12/16
Smurf1 Antibody Chemical Properties,Usage,Production
Source
Rabbit
Reactivity
Human
Background
Bone morphogenetic proteins constitute a large family of signaling molecules that regulate a wide range of critical processes including morphogenesis, cell-fate determination, proliferation, differentiation, and apoptosis. BMP receptors are members of the TGF-β superfamily of Ser/Thr kinase receptors. Ligand binding induces multimerization, autophosphorylation, and activation of these receptors. They subsequently phosphorylate SMAD1 at Ser463 and Ser465 in the carboxy-terminal motif SSXS, as well as SMAD5 and SMAD9 at their corresponding sites. These phosphorylated SMADs dimerize with the coactivating SMAD4 and translocate to the nucleus, where they regulate the transcription of target genes. MAP kinases and CDKs 8 and 9 are also reported to phosphorylate residues in the linker region of SMAD1, including Ser206. Phosphorylation of SMAD1 at Ser206 recruits Smurf1 to the linker region and leads to the degradation of SMAD1. Phosphorylation at this site also promotes SMAD1 transcriptional activity by recruiting YAP to the linker region.Smurf1, a member of the HECT family of E3 ubiquitin ligases, selectively interacts with BMP pathway Smad effectors, leading to Smad protein ubiquitination and degradation. In addition, Smurf1 interacts with the inhibitor Smad, Smad7, the bone-specific transcription factor Runx2/Cbfa1, RhoA and MEKK2. Smurf1 negatively regulates osteoblast differentiation and bone formation in vivo. A related protein, Smurf2, acts more promiscuously, interacting with both BMP and TGF-β pathway Smad proteins.
References
[1] Hogan, B.L. (1996) Genes Dev 10, 1580-94.
[2] Hoodless, P.A. et al. (1996) Cell 85, 489-500.
[3] Klemm, J.D. et al. (1998) Annu Rev Immunol 16, 569-92.
[4] Kretzschmar, M. et al. (1997) Genes Dev 11, 984-95.
[5] Whitman, M. (1998) Genes Dev 12, 2445-62.
[6] Sapkota, G. et al. (2007) Mol Cell 25, 441-54.
[7] Alarcón, C. et al. (2009) Cell 139, 757-69.
[8] Zhu, H. et al. (1999) Nature 400, 687-693.
[9] Ebisawa, T. et al. (2001) J. Biol. Chem. 276, 12477-12480.
[10] Zhao, M. et al. (2003) J. Biol. Chem. 278, 27939-27944.
Smurf1 Antibody Preparation Products And Raw materials
Raw materials
Preparation Products
Smurf1 Antibody Suppliers
- Tel
- 15921930842 15921930842
- yh-wang@univ-bio.com
- Country
- China
- ProdList
- 25004
- Advantage
- 58
- Tel
- 027-87196173
- cusabio@163.com
- Country
- China
- ProdList
- 6066
- Advantage
- 58
- Tel
- 027-19371278702 18008634902
- 19384116026@163.com
- Country
- China
- ProdList
- 3008
- Advantage
- 58
- Tel
- 0755-26755892 1-949-553-1900
- international@genetex.com
- Country
- China
- ProdList
- 6092
- Advantage
- 58
- Tel
- 858.663.9055 8586639055
- NSJBioname@qq.com
- Country
- China
- ProdList
- 6941
- Advantage
- 58
- Tel
- Enzo Biochem Inc. 13797054060
- Enzoname@qq.com
- Country
- China
- ProdList
- 6174
- Advantage
- 58
- Tel
- 18886812933
- sales@biosynth.com
- Country
- China
- ProdList
- 6218
- Advantage
- 58
- Tel
- 21-80243558 86218024
- info@cellsignal.cn
- Country
- China
- ProdList
- 6427
- Advantage
- 58
- Tel
- 4006-123-828 13162017139
- market@ab-mart.com
- Country
- China
- ProdList
- 6917
- Advantage
- 58
- Tel
- 51288865780
- sales@biosynth.com
- Country
- China
- ProdList
- 6051
- Advantage
- 58