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ASLAN003

Product Name
ASLAN003
CAS No.
1035688-66-4
Chemical Name
ASLAN003
Synonyms
ASLAN003;Farudodstat;Farudodstat, 10 mM in DMSO;2-[(3,5-Difluoro-3’-methoxy-4-biphenylyl)amino]nicotinic Acid;2-((3,5-difluoro-3'-methoxy-[1,1'-biphenyl]-4-yl)amino)nicotinic acid;2-((3,5-Difluoro-3'-methoxy-[1,1'-biphenyl]-4-yl)amino)nicotinic acid;2-[2,6-difluoro-4-(3-methoxyphenyl)anilino]pyridine-3-carboxylic acid;3-Pyridinecarboxylic acid, 2-[(3,5-difluoro-3'-methoxy[1,1'-biphenyl]-4-yl)amino]-;2-((3,5-Difluoro-3'-methoxy-[1,1'-biphenyl]-4-yl)amino)nicotinic acid , Farudodstat;AML,RPL6,synthesis,Farudodstat,OPP,ASLAN 003,acute,protein,orally,EIF4B,myeloid,caspase-3,DHODH,caspase-7,THP-1,AP-1,caspase-8,MOLM-14,Apoptosis,inhibit,KG-1,leukemia,Inhibitor,ASLAN-003,Dihydroorotate Dehydrogenase,DNA/RNA Synthesis
CBNumber
CB95540737
Molecular Formula
C19H14F2N2O3
Formula Weight
356.32
MOL File
1035688-66-4.mol
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ASLAN003 Property

Boiling point:
458.1±45.0 °C(Predicted)
Density 
1.376±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO:77.0(Max Conc. mg/mL);216.09(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:7):0.12(Max Conc. mg/mL);0.34(Max Conc. mM)
DMF:30.0(Max Conc. mg/mL);84.19(Max Conc. mM)
DMSO:77.0(Max Conc. mg/mL);216.09(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:7):0.12(Max Conc. mg/mL);0.34(Max Conc. mM)
DMF:30.0(Max Conc. mg/mL);84.19(Max Conc. mM)
form 
A crystalline solid
pka
2.84±0.29(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0104387
Product name
ASLAN003
Purity
99.95%
Packaging
10mg
Price
$550
Updated
2021/12/16
AK Scientific
Product number
2423DC
Product name
Aslan003
Packaging
1g
Price
$1275
Updated
2021/12/16
ChemScene
Product number
CS-0104387
Product name
ASLAN003
Purity
99.95%
Packaging
100mg
Price
$2250
Updated
2021/12/16
DC Chemicals
Product number
020563
Product name
Aslan003
Packaging
001
Price
$600
Updated
2021/12/16
DC Chemicals
Product number
020563
Product name
Aslan003
Packaging
002
Price
$950
Updated
2021/12/16
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ASLAN003 Chemical Properties,Usage,Production

Uses

Farudodstat (ASLAN003) is an orally active and potent Dihydroorotate Dehydrogenase (DHODH) inhibitor with an IC50 of 35 nM for human DHODH enzyme. Farudodstat inhibits protein synthesis via activation of AP-1 transcription factors. Farudodstat induces apoptosis and substantially prolongs survival in acute myeloid leukemia (AML) xenograft mice[1][2].

in vivo

Farudodstat (50 mg/kg; oral gavage; once daily; from the day 3 to 30) substantially reduces the number of disseminated tumors and prolongs survival[1].

Animal Model:Female NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ, NGS mice (4-6 weeks old) with MOLM-14 cells[1]
Dosage:50 mg/kg
Administration:Oral gavage; once daily; from the day 3 to 30
Result:Substantially reduced the number of disseminated tumors and the size of these tumors.
Survival was significantly prolonged.

References

[1] Jianbiao Zhou, et al. ASLAN003, a potent dihydroorotate dehydrogenase inhibitor for differentiation of acute myeloid leukemia. Haematologica. 2019 Nov7;haematol.2019.230482.
[2] Marco L. Lolli, et al. Human Dihydroorotate Dehydrogenase (hDHODH) as a new target on Acute Myelogenous Leukemia (AML): Targeting Myeloid Differentiation using Potent and Innovative hDHODH Inhibitors. 23rd Swedish Conference on Macromolecular Structure and Function T?llberg, 14-17 June 2019

ASLAN003 Preparation Products And Raw materials

Raw materials

Preparation Products

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ASLAN003 Suppliers

China 54 United States 5 Global 59
Shanghai Raise Chemical Technology Co.,Ltd
Tel
15026594951
Fax
0556-5030632
Email
rs@raise-chem.com
Country
China
ProdList
4454
Advantage
55
ShangHai Caerulum Pharma Discovery Co., Ltd.
Tel
18149758185
Email
sales-cpd@caerulumpharma.com
Country
China
ProdList
3506
Advantage
58
Sichuan Wei Keqi Biological Technology Co., Ltd.
Tel
028-81700200 18116577057
Fax
028-81705658
Email
3003855609@qq.com
Country
China
ProdList
7778
Advantage
56
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4757
Advantage
55
ShangHai Angti Biotechnology Co., Ltd.
Tel
13764913901
Fax
-
Email
info@angtibio.com
Country
China
ProdList
4986
Advantage
55
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
ShangHai Biochempartner Co.,Ltd
Tel
177-54423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
8000
Advantage
62
Shanghai Rechem science Co., Ltd.
Tel
021-31433387 15618786686
Fax
QQ:1369748377
Email
sales@rechemscience.com
Country
China
ProdList
2990
Advantage
58
Beijing Solarbio Science & Tecnology Co., Ltd.
Tel
010-50973130 18101056239
Email
3193328036@qq.com
Country
China
ProdList
29760
Advantage
68
Chuzhou KeMail Chemical Technology Co., Ltd
Tel
0550-5196001 15000891977
Fax
0550-5196001
Email
wj520wjxby@126.com
Country
China
ProdList
1944
Advantage
55

1035688-66-4, ASLAN003Related Search:


  • ASLAN003
  • 2-[(3,5-Difluoro-3’-methoxy-4-biphenylyl)amino]nicotinic Acid
  • 3-Pyridinecarboxylic acid, 2-[(3,5-difluoro-3'-methoxy[1,1'-biphenyl]-4-yl)amino]-
  • Farudodstat
  • AML,RPL6,synthesis,Farudodstat,OPP,ASLAN 003,acute,protein,orally,EIF4B,myeloid,caspase-3,DHODH,caspase-7,THP-1,AP-1,caspase-8,MOLM-14,Apoptosis,inhibit,KG-1,leukemia,Inhibitor,ASLAN-003,Dihydroorotate Dehydrogenase,DNA/RNA Synthesis
  • 2-[2,6-difluoro-4-(3-methoxyphenyl)anilino]pyridine-3-carboxylic acid
  • 2-((3,5-Difluoro-3'-methoxy-[1,1'-biphenyl]-4-yl)amino)nicotinic acid
  • Farudodstat, 10 mM in DMSO
  • 2-((3,5-difluoro-3'-methoxy-[1,1'-biphenyl]-4-yl)amino)nicotinic acid
  • 2-((3,5-Difluoro-3'-methoxy-[1,1'-biphenyl]-4-yl)amino)nicotinic acid , Farudodstat
  • 1035688-66-4