Bz-IEGR-pNA (acetate)
- Product Name
- Bz-IEGR-pNA (acetate)
- CAS No.
- 1325307-57-0
- Chemical Name
- Bz-IEGR-pNA (acetate)
- Synonyms
- Bz-Ile-Glu-Gly-Arg-p-nitroanilide;Bz-Ile-Glu-Gly-Arg-pNA · Acetate;Bz-Ile-Glu-Gly-Arg-pNA · Acetate （S-2222）;N-benzoyl-L-isoleucyl-L-α-glutamylglycyl-N-(4-nitrophenyl)-L-argininamide, monoacetate;BZ-ILE-GLU-GLY-ARG-PNA;BZ-ILE-GLU-GLY-ARG-P-NITROANILIDE;FACTOR XA CHROMOGENIC SUBSTRATE
- CBNumber
- CB95540878
- Molecular Formula
- C34H47N9O11
- Formula Weight
- 757.8
- MOL File
- 1325307-57-0.mol
Bz-IEGR-pNA (acetate) Property
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- form
- A crystalline solid
- Sequence
- {Bz-Ile}-Glu-Gly-Arg-{pNA}
- InChIKey
- ITXQNZUGLZNGBM-SFKTYRLKNA-N
- SMILES
- C(=O)(O)C.N(C1C=CC(N(=O)=O)=CC=1)C(=O)[C@H](CCCNC(N)=N)NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@]([H])([C@@H](C)CC)NC(C1C=CC=CC=1)=O |&1:16,31,40,42,r|
N-Bromosuccinimide Price
- Product number
- 27567
- Product name
- Bz-IEGR-pNA (acetate)
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 27567
- Product name
- Bz-IEGR-pNA (acetate)
- Packaging
- 25mg
- Price
- $533
- Updated
- 2024/03/01
- Product number
- 27567
- Product name
- Bz-IEGR-pNA (acetate)
- Packaging
- 5mg
- Price
- $139
- Updated
- 2024/03/01
- Product number
- 27567
- Product name
- Bz-IEGR-pNA (acetate)
- Packaging
- 10mg
- Price
- $243
- Updated
- 2024/03/01
- Product number
- 7159DU
- Product name
- Aceticacid;(4S)-4-[[(2S,3S)-2-benzamido-3-methylpentanoyl]amino]-5-[[2-[[(2S)-5-(diaminomethylideneamino)-1-(4-nitroanilino)-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-5-oxopentanoicacid
- Packaging
- 5mg
- Price
- $252
- Updated
- 2021/12/16
Bz-IEGR-pNA (acetate) Chemical Properties,Usage,Production
Description
Bz-IEGR-pNA acetate is a colorimetric substrate for Factor Xa. Factor Xa preferentially binds to and cleaves the Ile-Glu-Gly-Arg (IEGR) peptide sequence to release p-nitroanilide (pNA), which can be quantified by colorimetric detection at 405 nm as a measure of Factor Xa activity.
Uses
Bz-IEGR-pNA acetate is a trypsin substrate that can be hydrolyzed by prostate kinase release enzyme-related peptide KLKs[1].
Structure and conformation
The structure of Bz-IEGR-PNA Acetate is complex and contains several functional groups. One end consists of a benzoyl group (Bz), which is somewhat hydrophobic and can influence the molecule's interactions with other substances. The middle portion is a peptide composed of isoleucine (Ile), glutamic acid (Glu), glycine (Gly), and arginine (Arg), linked by peptide bonds.
Isoleucine has a long hydrophobic side chain that enhances the molecule's overall hydrophobicity.
Glutamic acid contains a carboxyl group, making it acidic.
Glycine has the simplest structure and is the smallest amino acid.
Arginine features a guanidinium group in its side chain, giving it strong basicity.
The peptide's amino acid sequence and structure determine its binding affinity to specific enzymes. The other end is attached to p-nitroaniline (PNA), whose nitro group is strongly electron-withdrawing, enabling this moiety to play a unique role in specific reactions. The entire molecule is conjugated with acetate to form Bz-IEGR-PNA Acetate; the acetate moiety may influence the compound's solubility and ionic properties in solution.
References
[1] Guo S, et al. Activation and activity of glycosylated KLKs 3, 4 and 11. Biol Chem. 2018 Sep 25;399(9):1009-1022. DOI:10.1515/hsz-2018-0148
Bz-IEGR-pNA (acetate) Preparation Products And Raw materials
Raw materials
Preparation Products
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