Arbutin-d4

Arbutin-d4 Property

solubility 

Water: soluble

Hazard and Precautionary Statements (GHS)

Arbutin-d4 Chemical Properties,Usage,Production

Description

Arbutin-d4 is intended for use as an internal standard for the quantification of arbutin (Item No. 26407) by GC- or LC-MS. Arbutin is a glycosylated hydroquinone that has been found in Arctostaphylos plants and has diverse biological activities, including tyrosinase inhibitory, antioxidant, and anti-inflammatory properties.1,2 It inhibits human tyrosinase activity in crude tyrosinase solution isolated from human melanocytes (IC50s = 5.7 and 18.9 mM using L-tyrosine and L-DOPA as substrates, respectively) as well as in intact melanocytes (IC50 = 0.5 mM).3 Arbutin (50 μM) inhibits hemolysis induced by the free radical generator AAPH (Item No. 82235) in sheep erythrocytes and inhibits AAPH-induced decreases in cell viability in cultured human skin fibroblasts when used at concentrations greater than 125 μM.2 In an LPS-induced rat model of acute lung injury, arbutin (50 mg/kg) prevents increases in IL-1β, IL-6, and TNF-α levels in lung tissue and serum.4 Formulations containing arbutin have been used in the treatment of hyperpigmentation disorders.WARNING This product is not for human or veterinary use.

References

[1] DONG-HO SEO. Biotechnological production of arbutins (α- and β-arbutins), skin-lightening agents, and their derivatives[J]. Applied Microbiology and Biotechnology, 2012, 95 6: 1417-1425. DOI: 10.1007/s00253-012-4297-4
[2] JUN TAKEBAYASHI. Reassessment of antioxidant activity of arbutin: multifaceted evaluation using five antioxidant assay systems.[J]. Free Radical Research, 2010, 44 4: 473-478. DOI: 10.3109/10715761003610760
[3] K MAEDA  M F. Arbutin: mechanism of its depigmenting action in human melanocyte culture.[J]. Journal of Pharmacology and Experimental Therapeutics, 1996, 276 2: 765-769.
[4] JINYAN YE . Arbutin attenuates LPS-induced lung injury via Sirt1/ Nrf2/ NF-κBp65 pathway[J]. Pulmonary pharmacology & therapeutics, 2019, 54: Pages 53-59. DOI: 10.1016/j.pupt.2018.12.001