AVEN antibody
Source Reactivity Background References- Product Name
- AVEN antibody
- Chemical Name
- AVEN antibody
- Synonyms
- AVEN antibody
- CBNumber
- CB95606963
- Formula Weight
- 0
- MOL File
- Mol file
N-Bromosuccinimide Price
- Product number
- orb13263
- Product name
- AVEN antibody
- Purity
- Affinity purified by Protein A
- Packaging
- 100μg
- Price
- $421.6
- Updated
- 2021/12/16
- Product number
- orb13263
- Product name
- AVEN antibody
- Purity
- Affinity purified by Protein A
- Packaging
- 200μg
- Price
- $673.2
- Updated
- 2021/12/16
AVEN antibody Chemical Properties,Usage,Production
Source
Rabbit
Reactivity
Human;Mouse;Rat;Monkey
Background
The Bcl-2 family regulates apoptosis in response to a wide range of stimuli through control of mitochondrial cytochrome c release and caspase activation. Cytosolic Apaf-1 forms a complex with caspase-9 in the presence of cytochrome c and dATP, ultimately leading to caspase-9 activation and subsequent activation of caspase-3. A large number of proteins have been found to interact with Bcl-2 and other family members that have been shown to help regulate apoptosis. Aven was identified in a yeast two-hybrid screen as a bcl-xL interacting protein. It also interacts with other anti-apoptotic family members, including Bcl-2, but fails to interact with pro-apopotic proteins Bax and Bak. Aven inhibits apoptosis and enhances anti-apopotic activity of Bcl-xL. It interferes with association with Apaf-1 and activation of caspase-9. Aven overexpression is associated with poor prognosis in acute lymphoblastic leukemia.
References
[1] Harris, M.H. and Thompson, C.B. (2000) Cell Death. Differ. 7, 1182-1191.
[2] Cory, S. et al. (2003) Oncogene 22, 8590-8607.
[3] Scorrano, L. and Korsmeyer, S.J. (2003) Biochem. Biophys. Res. Commun. 304, 437-444.
[4] Chau, B.N. et al. (2000) Mol. Cell 6, 31-40.
[5] Choi, J. et al. (2006) Leuk. Res. 30, 1019-1025.
[6] Paydas, S. et al. (2003) Ann. Oncol. 14, 1045-1050.
AVEN antibody Preparation Products And Raw materials
Raw materials
Preparation Products
AVEN antibody Suppliers
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