GOT2 antibody
Source Reactivity Background References- Product Name
- GOT2 antibody
- Chemical Name
- GOT2 antibody
- Synonyms
- GOT2 antibody
- CBNumber
- CB95631992
- Formula Weight
- 0
- MOL File
- Mol file
N-Bromosuccinimide Price
- Product number
- orb183987
- Product name
- GOT2 antibody
- Purity
- Affinity purified by Protein A
- Packaging
- 100μg
- Price
- $421.6
- Updated
- 2021/12/16
- Product number
- orb183987
- Product name
- GOT2 antibody
- Purity
- Affinity purified by Protein A
- Packaging
- 200μg
- Price
- $673.2
- Updated
- 2021/12/16
GOT2 antibody Chemical Properties,Usage,Production
Source
Rabbit
Reactivity
Human;Mouse;Rat;Monkey
Background
Glutamate oxaloacetate transaminase 2, a mitochondrial enzyme, catalyzes the conversion of oxaloacetate to aspartate. Studies show that the metabolite pyridoxal phosphate is selectively required by acute myeloid leukemia. PLP-dependent GOT2 selectively sustains leukemic cell proliferation. Depletion of GOT2 suppresses the proliferation of acute myeloid leukemia cells. In addition, mouse hematopoietic stem cells are dependent on cell-autonomous aspartate synthesis. Got2 deletion leads to decreased aspartate levels and reduced hematopoietic stem cell function. Furthermore, GOT2-dependent aspartate synthesis is also necessary for protein and collagen biosynthesis in chondrocytes and is critical for chondrocyte proliferation and growth.
References
[1] Chen, C.C. et al. (2020) Cancer Cell 37, 71-84.e7.
[2] Qi, L. et al. (2021) Cell Stem Cell 28, 1982-1999.e8.
[3] Stegen, S. et al. (2020) Dev Cell 53, 530-544.e8.
GOT2 antibody Preparation Products And Raw materials
Raw materials
Preparation Products
GOT2 antibody Suppliers
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