LASP1 antibody
Source Reactivity Background References- Product Name
- LASP1 antibody
- Chemical Name
- LASP1 antibody
- Synonyms
- LASP1 antibody
- CBNumber
- CB95650724
- Formula Weight
- 0
- MOL File
- Mol file
N-Bromosuccinimide Price
- Product number
- orb184836
- Product name
- LASP1 antibody
- Purity
- Affinity purified by Protein A
- Packaging
- 100μg
- Price
- $421.6
- Updated
- 2021/12/16
- Product number
- orb184836
- Product name
- LASP1 antibody
- Purity
- Affinity purified by Protein A
- Packaging
- 200μg
- Price
- $673.2
- Updated
- 2021/12/16
LASP1 antibody Chemical Properties,Usage,Production
Source
Rabbit
Reactivity
Human
Background
LASP1 is a cytoskeletal scaffold protein belonging to the LIM protein subfamily. LASP1 consists of an N-terminal LIM domain, followed by two nebulin repeats, and a C-terminal SH3 domain. The nebulin repeats interact with actin, while the SH3 domain interacts with palladin, suggesting LASP1 functions as an actin-binding protein, possibly in cytoskeletal organization. LASP1 has been shown to localize to focal adhesions, lamellipodia, and membrane ruffles and might be involved in membrane migration. Overexpression of LASP1 has been associated with metastatic cancers, such as breast and ovarian cancer. In these cases, membrane, cytoplasmic, and nuclear localization of LASP1 in the tumor cell has been reported, suggesting LASP1 involvement in membrane and nuclear signaling.
References
[1] Tomasetto, C. et al. (1995) FEBS Lett 373, 245-9.
[2] Grunewald, T.G. and Butt, E. (2008) Mol Cancer 7, 31.
[3] Schreiber, V. et al. (1998) Mol Med 4, 675-87.
[4] Chew, C.S. et al. (2002) J Cell Sci 115, 4787-99.
[5] Rachlin, A.S. and Otey, C.A. (2006) J Cell Sci 119, 995-1004.
[6] Chew, C.S. et al. (2000) J Cell Sci 113 ( Pt 11), 2035-45.
[7] Lin, Y.H. et al. (2004) J Cell Biol 165, 421-32.
[8] Grunewald, T.G. et al. (2007) Br J Cancer 96, 296-305.
[9] Frietsch, J.J. et al. (2010) Br J Cancer 102, 1645-1653.
[10] Traenka, C. et al. (2010) Cancer Res 70, 8003-8014.
LASP1 antibody Preparation Products And Raw materials
Raw materials
Preparation Products
LASP1 antibody Suppliers
- Tel
- 025-52151215 13915956535 13915956535
- 570945402@qq.com
- Country
- China
- ProdList
- 9733
- Advantage
- 58
- Tel
- 18007124176 19384116026
- 2706668885@qq.com
- Country
- China
- ProdList
- 4987
- Advantage
- 58
- Tel
- 400821347
- orders@novusbio.com
- Country
- China
- ProdList
- 6433
- Advantage
- 58
- Tel
- 027-87196173
- cusabio@163.com
- Country
- China
- ProdList
- 6066
- Advantage
- 58
- Tel
- 027-19371278702 18008634902
- ruihening88@163.com
- Country
- China
- ProdList
- 3009
- Advantage
- 58
- Tel
- 0755-26755892 1-949-553-1900
- international@genetex.com
- Country
- China
- ProdList
- 6092
- Advantage
- 58
- Tel
- 858.663.9055 8586639055
- NSJBioname@qq.com
- Country
- China
- ProdList
- 6941
- Advantage
- 58
- Tel
- Enzo Biochem Inc. 13797054060
- Enzoname@qq.com
- Country
- China
- ProdList
- 6174
- Advantage
- 58
- Tel
- 18886812933
- sales@biosynth.com
- Country
- China
- ProdList
- 6218
- Advantage
- 58
- Tel
- 21-80243558 86218024
- info@cellsignal.cn
- Country
- China
- ProdList
- 6725
- Advantage
- 58