Description Source Background References

Mouse Vascular Endothelial Growth Factor-164 (mVEGF164 )

Description Source Background References
Product Name
Mouse Vascular Endothelial Growth Factor-164 (mVEGF164 )
Chemical Name
Mouse Vascular Endothelial Growth Factor-164 (mVEGF164 )
Synonyms
Mouse Vascular Endothelial Growth Factor-164 (mVEGF164 )
CBNumber
CB95660378
Formula Weight
0
MOL File
Mol file
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Hazard and Precautionary Statements (GHS)

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Mouse Vascular Endothelial Growth Factor-164 (mVEGF164 ) Chemical Properties,Usage,Production

Description

The bioactivity of recombinant mVEGF164 was determined in a cell proliferation assay using HUVEC. The ED50 of each lot is between 1-5 ng/ml.

Source

Human 293 Cells

Background

VEGF164 is one of many splice variants of the mouse VEGF-A gene, and is one amino acid shorter than its human counterpart, VEGF165. VEGF164 is produced by a number of cells including endothelial cells, macrophages and T cells. VEGF164 is involved in angiogenesis, vascular endothelial cell survival, growth, migration and vascular permeability. Gene expression is induced by hypoxia, inflammatory cytokines and oncogenes. VEGF164 binds to heparan sulfate and is retained on the cell surface and in the extracellular matrix. VEGFR1 and VEGFR2 are the receptor tyrosine kinases for VEGF164. NRP-1 and NRP-2 may function as co-receptors and enhance VEGFR2 signaling. Binding of VEGF164 to VEGFR1 and VEGR2 leads to activation of the PI3K/AKT, p38 MAPK, FAK and Paxillin.

References

[1] Haigh, J.J. (2008) Organogenesis 4, 247-56.
[2] Takahashi, H. and Shibuya, M. (2005) Clin Sci (Lond) 109, 227-41.
[3] Neufeld, G. et al. (1999) FASEB J 13, 9-22.

Mouse Vascular Endothelial Growth Factor-164 (mVEGF164 ) Preparation Products And Raw materials

Raw materials

Preparation Products

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Mouse Vascular Endothelial Growth Factor-164 (mVEGF164 ) Suppliers

CHINA 8 Global 8
Cell Signaling Technology Inc
Tel
21-80243558 86218024
Email
info@cellsignal.cn
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China
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6725
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Beijing Boning Biotechnology Co., Ltd.
Tel
010-67500625 18210120938
Email
384669408@qq.com
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China
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195
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58
Shanghai Haoye Biotechnology Co., Ltd.
Tel
15121098156
Country
CHINA
ProdList
134
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58

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