ChemicalBook > CAS DataBase List > CSF1R-IN-2

CSF1R-IN-2

Product Name: CSF1R-IN-2
CAS No.: 2271119-26-5
Chemical Name: CSF1R-IN-2
Synonyms: TPX-0022;CSF1R-IN-2;Elzovantinib;CSF1R inhibitor 2;TPX-0022(CSF1R-IN-2);Elzovantinib (TPX-0022);CSF1R-IN-2, 10 mM in DMSO;Elzovantinib (TPX-0022) ，S9620;Elzovantinib (TPX-0022, CSF1R-IN-2);colony stimulating factor 1 receptor,CSF-1R,CSF1R IN 2,inhibit,CSF1RIN2,c-Met/HGFR,CSF1R,CSF-1R-IN-2,Inhibitor,CSF-1 receptor,Src,c-Fms
CBNumber: CB95848846
Molecular Formula: C20H20FN7O2
Formula Weight: 409.42
MOL File: 2271119-26-5.mol

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CSF1R-IN-2 Property

storage temp.: Store at -20°C
solubility: DMSO : 25 mg/mL (61.06 mM; Need ultrasonic)
form: A solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0091874
Product name: CSF1R-IN-2
Purity: 99.97%
Packaging: 5mg
Price: $350
Updated: 2021/12/16

ChemScene

Product number: CS-0091874
Product name: CSF1R-IN-2
Purity: 99.97%
Packaging: 10mg
Price: $550
Updated: 2021/12/16

ChemScene

Product number: CS-0091874
Product name: CSF1R-IN-2
Purity: 99.97%
Packaging: 50mg
Price: $1650
Updated: 2021/12/16

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CSF1R-IN-2 Chemical Properties,Usage,Production

Uses

Elzovantinib (TPX-0022) is an oral-active inhibitor of SRC, MET and c-FMS, with IC50 values of 0.12 nM, 0.14 nM and 0.76 nM for SRC, MET and c-FMS respectively[1].

in vivo

Elzovantinib (TPX-0022; p.o., BID, 13 days) treatment results in an 85% tumor regression and no body weight loss is observed after 21 days treatment in mice^[1].
Elzovantinib (p.o., BID, 10 days) demonstrates the ability to inhibit tumor growth at 44% and 67% at the dose of 5 mg/kg, BID and 15 mg/kg, BID, respectively in SCID/Beige mice^[1].
Elzovantinib inhibits MET activity in MKN-45 tumors following oral administration in mice^[1].

Animal Model:	Mice bearing LU2503 tumors patient derived xenograft (PDX) NSCLC model^[1].
Dosage:	15 mg/kg.
Administration:	PO, BID (twice daily) for 13 days.
Result:	Resulted in an 85% tumor regression and no body weight loss was observed after 21 days treatment.

Animal Model:	SCID/Beige mice bearing Ba/F3 ETV6-CSF1R tumors with average tumor size of ~180 mm³^[1].
Dosage:	5 and 15 mg/kg.
Administration:	PO, BID (twice daily) for 10 days.
Result:	Demonstrated the ability to inhibit tumor growth at 44% and 67% at the dose of 5 mg/kg, BID and 15 mg/kg, BID, respectively.

References

[1] WO 2019023417 A1.

CSF1R-IN-2 Preparation Products And Raw materials

Raw materials

Preparation Products

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2271119-26-5, CSF1R-IN-2Related Search:

Repotrectinib TPX-0131 17,19-Metheno-1H,5H-cyclopent[5,6][1,4]oxazino[3,4-i]pyrazolo[4,3-f]pyrido[3,2-l][1,4,8,10]oxatriazacyclotridecin-14(11H)-one, 7-fluoro-2,3,3a,12,13,20a-hexahydro-11-methyl-, (3aS,11R,20aR)- TPX-0046

CSF1R-IN-2

CSF1R inhibitor 2

1,15-Etheno-1H-pyrazolo[4,3-f][1,4,8,10]benzoxatriazacyclotridecine-12-carbonitrile, 3-amino-14-ethyl-11-fluoro-4,5,6,7,13,14-hexahydro-7-methyl-4-oxo-, (7S)-

TPX-0022

TPX-0022(CSF1R-IN-2)

Elzovantinib (TPX-0022)

colony stimulating factor 1 receptor,CSF-1R,CSF1R IN 2,inhibit,CSF1RIN2,c-Met/HGFR,CSF1R,CSF-1R-IN-2,Inhibitor,CSF-1 receptor,Src,c-Fms

Elzovantinib

(S)-12-Amino-2-ethyl-45-fluoro-6-methyl-9-oxo-5-oxa-2,8-diaza-1(5,3)-pyrazolo[1,5-a]pyrimidina-4(1,2)-benzenacyclononaphane-46-carbonitrile

CSF1R-IN-2, 10 mM in DMSO

Elzovantinib (TPX-0022, CSF1R-IN-2)

Elzovantinib (TPX-0022) ，S9620

2271119-26-5