Repotrectinib

Binding Mode

Product Name: Repotrectinib
CAS No.: 1802220-02-5
Chemical Name: Repotrectinib
Synonyms: Repotrectinib;TPX-005;Ropotrectinib;CS-2479;TPX-0005;Loprotinib;PX0005(Ropotrectinib);TPX0005(Ropotrectinib);Repotrectinib,TPX-0005;TPX-0005,Repotrectinib
CBNumber: CB83312797
Molecular Formula: C18H18FN5O2
Formula Weight: 355.37
MOL File: 1802220-02-5.mol

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Repotrectinib Property

Density: 1.46±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO:35.0(Max Conc. mg/mL);98.5(Max Conc. mM)
Ethanol:10.0(Max Conc. mg/mL);28.1(Max Conc. mM)
form: A crystalline solid
pka: 10.79±0.60(Predicted)
color: White to off-white
InChI: InChI=1S/C18H18FN5O2/c1-10-8-20-18(25)14-9-21-24-6-5-16(23-17(14)24)22-11(2)13-7-12(19)3-4-15(13)26-10/h3-7,9-11H,8H2,1-2H3,(H,20,25)(H,22,23)/t10-,11+/m0/s1
InChIKey: FIKPXCOQUIZNHB-WDEREUQCSA-N
SMILES: O1C2=CC=C(F)C=C2[C@@H](C)NC2C=CN3C(N=2)=C(C=N3)C(=O)NC[C@@H]1C

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 23397
Product name: TPX-0005
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 23397
Product name: TPX-0005
Purity: ≥98%
Packaging: 5mg
Price: $139
Updated: 2024/03/01

Cayman Chemical

Product number: 23397
Product name: TPX-0005
Purity: ≥98%
Packaging: 10mg
Price: $243
Updated: 2024/03/01

Cayman Chemical

Product number: 23397
Product name: TPX-0005
Purity: ≥98%
Packaging: 25mg
Price: $533
Updated: 2024/03/01

ChemScene

Product number: CS-7628
Product name: Repotrectinib
Purity: 99.81%
Packaging: 5mg
Price: $120
Updated: 2021/12/16

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Repotrectinib Chemical Properties,Usage,Production

Binding Mode

The cocrystal structures of repotrectinib with TRK proteins are yet to be reported. However, a docking model with TRKA suggests that the pyrazole nitrogen forms hydrogen bonds with Met592 in the hinge area. The fluorophenyl group, positioned in a hydrophobic pocket, aligns perpendicularly to the macrocycle, and the lactam oxygen atom engages in a water-mediated hydrogen bond with Met592 in the hinge region (Figs. 1,2).

Description

Ropotrectinib (TPX-0005; TP Therapeutics, San Diego, CA, USA) is a nextgeneration ROS1 inhibitor, a novel three-dimensional macrocyle with a much smaller size (MW <370) than current ROS1 inhibitors. It was specifically designed to overcome resistance mutations. Preclinical studies have shown activity against gatekeeper and solvent mutations, including G2032R, D2033N, L2026M, S1986F/Y, L1951R, and kinases involved in bypass signaling such as focal adhesion kinase, SRC proto-oncogene, and non-receptor tyrosine kinase [102, 103].

Description

Repotrectinib, also known as TPX-0005, is a multikinase (ROS1, ALK, and TRKA/B/C) inhibitor that is tested in an ongoing first-in-human phase 1/2 trail (NCT03093116).

brand name

Augtyro

General Description

Class: receptor tyrosine kinase; Treatment: NSCLC; Other name: TPX-0005

Biological Activity

Repotrectinib is a potent inhibitor targeting solvent-front mutations (SFMs) of ROS1, pan-TRK, and ALK. It effectively inhibits the kinase activity of wild-type ROS1, TRKA-C, and ALK, along with their SFMs, with IC50 values ranging from 0.071 to 4.46 nM. The compound shows high potency against ROS1 and TRKA-C, with approximately 15-fold selectivity over ALK.

Clinical Use

Repotrectinib has advantage with central nervous system (CNS) penetration, aimed to target both wide-type (WT) and solvent-front mutations (SFM) kinases and other resistance mutations including ROS1-G2032R and ROS1-D2033N, TRKA-G595R, TRKB-G639R, TRKC-G623R, and ALK-G1202R.

Side effects

Common side effects of Repotrectinib include dizziness, taste disturbances, and abnormal sensations. Other possible side effects are: constipation, diarrhoea, tiredness, weakness or malaise; swelling of the face, eyes, arms, legs, hands or feet; weight gain; burning, tingling or numbness in the hands and feet. Severe can lead to breathing problems, muscle pain, pressure or weakness; vision changes, bone pain, difficulty moving or skeletal abnormalities.

target

Primary targets: NTRK, ROS, ALT

Repotrectinib Preparation Products And Raw materials

Raw materials

Preparation Products

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Repotrectinib Suppliers

China 179 United States 9 Global 188

Anqing Benro pharmachem Technology Co.,Ltd.

Tel: 05565209906 15391842992
Email: 794263564@qq.com
Country: China
ProdList: 123
Advantage: 58

Chunchuang (Wuhan) Technology Co., Ltd

Tel: 15727060112
Email: yutianchun2007@126.com
Country: China
ProdList: 9814
Advantage: 58

ShangHai Caerulum Pharma Discovery Co., Ltd.

Tel: 18149758185
Email: sales-cpd@caerulumpharma.com
Country: China
ProdList: 3506
Advantage: 58

Suzhou Ryan Pharmaceutical Technology Co., Ltd.

Tel: 0512-68780025 18962125825
Email: sales@ryanchem.com
Country: China
ProdList: 167
Advantage: 62

Beijing Zhongshuo Pharmaceutical Technology Development Co., Ltd

Tel: 13801208576
Fax: 010-64215766
Email: maggie@chinazhongshuo.com
Country: China
ProdList: 77
Advantage: 65

Nantong Hanfang Biotechnology Co. , Ltd.

Tel: hanfangpharma@126.com; 18616537568
Email: hanfangpharma@126.com
Country: China
ProdList: 29965
Advantage: 58

Dalian Meilun Biotech Co., Ltd.

Tel: 0411-62910999 13889544652
Email: sales@meilune.com
Country: China
ProdList: 4747
Advantage: 58

Shanghai Hope Chem Co., Ltd.，

Tel: +21-18501659228 18501659228
Fax: sales@hope-chem.com
Email: info@hope-chem.com
Country: China
ProdList: 474
Advantage: 55

MedChemexpress LLC

Tel: 021-58955995
Fax: 609-228-5909
Email: sales@medchemexpress.cn
Country: United States
ProdList: 4861
Advantage: 58

TargetMol Chemicals Inc.

Tel: 021-021-33632979 15002134094
Fax: 021-33632979
Email: marketing@targetmol.com
Country: China
ProdList: 7783
Advantage: 58

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View Lastest Price from Repotrectinib manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: Repotrectinib 1802220-02-5
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1000kg
Release date: 2025-09-28

BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.

Product: Repotrectinib 1802220-02-5
Price: US $0.00/g
Min. Order: 1g
Purity: More Than 99%
Supply Ability: 50kg/Month
Release date: 2025-09-10

Jinan Million Pharmaceutical Co., Ltd

Product: Repotrectinib/TPX-0005 1802220-02-5
Price: US $2.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 50KG/M
Release date: 2023-08-14

1802220-02-5, RepotrectinibRelated Search:

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Ropotrectinib

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CS-2479

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Repotrectinib

Repotrectinib,TPX-0005

TPX-0005

1,15-Etheno-1H-pyrazolo[4,3-f][1,4,8,10]benzoxatriazacyclotridecin-4(5H)-one,11-fluoro-6,7,13,14-tetrahydro-7,13-dimethyl-, (7S,13R)-

TPX-0005,Repotrectinib

TPX-005

TPX0005(Ropotrectinib)

Ropotrectinib(TPX0005)

Loprotinib

(7S,13R)-11-Fluoro-6,7,13,14-tetrahydro-7,13-dimethyl-1,15-etheno-1H-pyrazolo[4,3-f][1,4,8,10]benzoxatriazacyclotridecin-4(5H)-one

PX0005(Ropotrectinib)

Repotrectinib, 10 mM in DMSO

1802220-02-5

180222-02-5

API

1802220-02-5