LOXO-195
- Product Name
- LOXO-195
- CAS No.
- 1350884-56-8
- Chemical Name
- LOXO-195
- Synonyms
- LOXO-195;LOXO-195(3aR);(6RS)-LOXO-195;LOXO195 R racemic;Selitrectinib Racemate;LOXO-195, 10 mM in DMSO;Selitrectinib Impurity 4;Selitrectinib(LOXO-195) Racemate;(18bR)-17-Fluoro-1,2,3,11,12,13,14,18b-octahydro-12-methyl-10H-5,7-ethenopyrazolo[3,4-d]pyrido[2,3-k]pyrrolo[2,1-m][1,3,7]triazacyclotridecin-10-one;12H-15,17-Ethenopyrazolo[3,4-d]pyrido[2,3-k]pyrrolo[2,1-m][1,3,7]triazacyclotridecin-12-one, 5-fluoro-1,2,3,3a,8,9,10,11-octahydro-10-methyl-, (3aR)-
- CBNumber
- CB73311672
- Molecular Formula
- C20H21FN6O
- Formula Weight
- 380.42
- MOL File
- 1350884-56-8.mol
LOXO-195 Property
- Density
- 1.51±0.1 g/cm3(Predicted)
- pka
- 11.44±0.40(Predicted)
- InChI
- InChI=1S/C20H21FN6O/c1-12-4-5-16-14(9-13(21)10-22-16)17-3-2-7-26(17)18-6-8-27-19(25-18)15(11-23-27)20(28)24-12/h6,8-12,17H,2-5,7H2,1H3,(H,24,28)/t12,17-/m1/s1
- InChIKey
- OEBIHOVSAMBXIB-RGUGMKFQSA-N
- SMILES
- N12CCC[C@]1([H])C1=CC(F)=CN=C1CCC(C)NC(=O)C1C=NN3C=CC2=NC=13
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 453924
- Product name
- LOXO-195
- Packaging
- 1mg
- Price
- $496
- Updated
- 2021/12/16
LOXO-195 Chemical Properties,Usage,Production
Description
LOXO-195 is an orally available, highly potent, and selective TRK kinase inhibitor designed to overcome drug resistance mediated by acquired mutations. Although responses to TRK inhibition can be dramatic and durable; however, eventually emergence of acquired resistance is found to be inevitable.
Uses
(3aR)-Selitrectinib ((3aR)-LOXO-195) is an isform of Selitrectinib (HY-101977), which is a next-generation TRK kinase inhibitor, with IC50s of 0.6 nM and <2.5 nM for TRKA and TRKC, respectively[1].
References
[1] Drilon A, et al. A Next-Generation TRK Kinase Inhibitor Overcomes Acquired Resistance to Prior TRK Kinase Inhibition in Patients with TRK Fusion-Positive Solid Tumors. Cancer Discov. 2017 Sep;7(9):963-972. DOI:10.1158/2159-8290.CD-17-0507
LOXO-195 Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from LOXO-195 manufacturers
- Product
- LOXO-195 1350884-56-8
- Price
- US $2.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 100g , 1kg, 5kg , 50kg
- Release date
- 2020-01-07