Buparlisib Hydrochloride
- Product Name
- Buparlisib Hydrochloride
- CAS No.
- 1312445-63-8
- Chemical Name
- Buparlisib Hydrochloride
- Synonyms
- CS-2154;BKM 120AAA;NVP-BKM120 HCl;Buparlisib HCl;BKM-120 (HCl salt);NVP-BKM120 HCl salt;BKM120 hydrochloride;BKM-120 hydrochloride;BKM 120 hydrochloride;NVP-BKM120 (HYDROCHLORI
- CBNumber
- CB72624269
- Molecular Formula
- C18H22ClF3N6O2
- Formula Weight
- 446.86
- MOL File
- 1312445-63-8.mol
Buparlisib Hydrochloride Property
- storage temp.
- Store at -20°C
- solubility
- ≥44.7 mg/mL in DMSO; ≥52.8 mg/mL in H2O with gentle warming; ≥96 mg/mL in EtOH with gentle warming
- form
- solid
- color
- White to yellow
- InChI
- InChI=1S/C18H21F3N6O2.ClH/c19-18(20,21)13-9-15(22)23-11-12(13)14-10-16(26-1-5-28-6-2-26)25-17(24-14)27-3-7-29-8-4-27;/h9-11H,1-8H2,(H2,22,23);1H
- InChIKey
- DGPLYAXBXJXEID-UHFFFAOYSA-N
- SMILES
- C(C1=CC(N)=NC=C1C1=NC(N2CCOCC2)=NC(N2CCOCC2)=C1)(F)(F)F.Cl
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H300Fatal if swallowed
H341Suspected of causing genetic defects
H372Causes damage to organs through prolonged or repeated exposure
H400Very toxic to aquatic life
H411Toxic to aquatic life with long lasting effects
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P273Avoid release to the environment.
P281Use personal protective equipment as required.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P308+P313IF exposed or concerned: Get medical advice/attention.
P314Get medical advice/attention if you feel unwell.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P391Collect spillage. Hazardous to the aquatic environment
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- CS-0820
- Product name
- BuparlisibHydrochloride
- Purity
- 99.79%
- Packaging
- 5mg
- Price
- $72
- Updated
- 2021/12/16
- Product number
- A3674
- Product name
- NVP-BKM120Hydrochloride
- Packaging
- 5mg
- Price
- $90
- Updated
- 2021/12/16
- Product number
- CS-0820
- Product name
- BuparlisibHydrochloride
- Purity
- 99.79%
- Packaging
- 10mg
- Price
- $108
- Updated
- 2021/12/16
- Product number
- orb611812
- Product name
- NVP-BKM120 hydrochloride
- Packaging
- 10mg
- Price
- $210.8
- Updated
- 2021/12/16
- Product number
- KIN0001499
- Product name
- BKM-120 HYDROCHLORIDE
- Purity
- 95.00%
- Packaging
- 10MG
- Price
- $253.05
- Updated
- 2021/12/16
Buparlisib Hydrochloride Chemical Properties,Usage,Production
Uses
NVP-BKM 120-d16 Hydrochloride is the salt, labeled analogue of NVP-BKM 120 (N925760), a novel anti-tumor active compound that is selective in that it inhibits specifically PI3 kinase activating cell death in glioma cells. Glioma cells being those that proliferate from tumors in the brain or the spine.
Definition
Buparlisib hydrochloride (BKM120 Hydrochloride) is an investigational small molecule orally available pan-class I phosphoinositide 3-kinase inhibitor, with IC50 of 52 nM/166 nM/116 nM/262 nM for p110α/p110β/p110δ/p110γ, respectively.
Mode of action
Buparlisib specifically inhibits class I PIK3 in the PI3K/AKT kinase signaling pathway in an ATP-competitive manner, thus inhibiting the production of the secondary messenger phosphatidylinositol (3,4,5)-trisphosphate and activation of the PI3K signaling pathway. This may induce inhibition of tumour cell growth and survival in susceptible tumour cell populations. Buparlisib is currently under investigation in patients with a variety of solid tumours, including breast cancer[1].
References
[1] Carmen Criscitiello. “Profile of buparlisib and its potential in the treatment of breast cancer: evidence to date.” Breast Cancer?: Targets and Therapy 10 (2018): 23–29.
Buparlisib Hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
Buparlisib Hydrochloride Suppliers
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View Lastest Price from Buparlisib Hydrochloride manufacturers
- Product
- NVP-BKM120 (Hydrochloride) 1312445-63-8
- Price
- US $2.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- ask
- Release date
- 2018-12-23