LOXO-195

Product Name: LOXO-195
CAS No.: 2097002-61-2
Chemical Name: LOXO-195
Synonyms: CS-2800;Selitrectinib;LOXO-195;LOXO195;LOXO-195(3aR,10R);LOXO-195 USP/EP/BP;LOXO-195(Slitrecrinib);selitrectinib（LOXO-195）;LOXO 195(Selitrectinib);Selitrectinib (BAY 2731954;Selitrectinib, 10 mM in DMSO
CBNumber: CB83367232
Molecular Formula: C20H21FN6O
Formula Weight: 380.42
MOL File: 2097002-61-2.mol

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LOXO-195 Property

Density: 1.51±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO:62.5(Max Conc. mg/mL);164.29(Max Conc. mM)
form: A crystalline solid
pka: 11.44±0.40(Predicted)
color: White to yellow
InChI: InChI=1S/C20H21FN6O/c1-12-4-5-16-14(9-13(21)10-22-16)17-3-2-7-26(17)18-6-8-27-19(25-18)15(11-23-27)20(28)24-12/h6,8-12,17H,2-5,7H2,1H3,(H,24,28)/t12-,17-/m1/s1
InChIKey: OEBIHOVSAMBXIB-SJKOYZFVSA-N
SMILES: N12CCC[C@]1([H])C1=CC(F)=CN=C1CC[C@@H](C)NC(=O)C1C=NN3C=CC2=NC=13

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Safety

HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 27062
Product name: LOXO-195
Packaging: 5mg
Price: $684
Updated: 2024/03/01

Cayman Chemical

Product number: 27062
Product name: LOXO-195
Packaging: 10mg
Price: $1139
Updated: 2024/03/01

Cayman Chemical

Product number: 27062
Product name: LOXO-195
Packaging: 1mg
Price: $153
Updated: 2024/03/01

TRC

Product number: L469348
Product name: LOXO-195
Packaging: 1mg
Price: $185
Updated: 2021/12/16

ChemScene

Product number: CS-0022378
Product name: Selitrectinib
Purity: 99.90%
Packaging: 10mg
Price: $150
Updated: 2021/12/16

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LOXO-195 Chemical Properties,Usage,Production

Uses

LOXO-195 (Selitrectinib) is a second-generation TRK kinase inhibitor that targets TRK fusion-positive tumors and is used to treat tumor patients who are resistant to first-generation TRK inhibitors.

in vivo

Stably transfected NIH-3T3 ΔTRKA and ΔTRKA-G595R cells are implanted subcutaneously into the flanks of nude mice. Both larotrectinib and Selitrectinib (LOXO-195) are effective at reducing phosphorylated TRKA in tumors driven by ΔTRKA. In contrast, only Selitrectinib (LOXO-195) strongly suppresses phospho-TRKA in ΔTRKA-G595R cells in a dose-dependent manner. Selitrectinib (LOXO-195) also causes inhibition of tumor growth relative to vehicle at all doses in four TRKA-dependent tumor models (ΔTRKA, ΔTRKA-G595R, ΔTRKAG667C, and TPM3-NTRK1 fusion-positive KM12 colorectal cancer cells. Larotrectinib inhibits KM12 and NIH 3T3-ΔTRKA tumors to a similar degree. Group mean body weight loss does not exceed 5% for any agent. Selitrectinib (LOXO-195) displays high selectivity for the TRK proteins^[1]

IC 50

TrkA: 0.6 nM (IC₅₀); TrkC: <2.5 nM (IC₅₀)

LOXO-195 Preparation Products And Raw materials

Raw materials

Preparation Products

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LOXO-195 Suppliers

China 107 India 1 United States 6 Global 114

Changzhou Fulangke Chemical Technology Co., Ltd.

Tel: 13776872728
Email: amwpl888@sina.cn
Country: China
ProdList: 22
Advantage: 58

Hubei Kele Fine Chemical Co., Ltd

Tel: 027-59101668 19945030958
Fax: 027-59101668
Email: 2881924765@qq.com
Country: China
ProdList: 7938
Advantage: 58

TargetMol Chemicals Inc.

Tel: 021-021-33632979 15002134094
Fax: 021-33632979
Email: marketing@targetmol.com
Country: China
ProdList: 7783
Advantage: 58

Dalian Meilun Biotech Co., Ltd.

Tel: 0411-62910999 13889544652
Email: sales@meilune.com
Country: China
ProdList: 4747
Advantage: 58

Shanghai Topbiochem Technology Co., Ltd

Tel: 021-58170097
Email: info@topbiochem.com
Country: China
ProdList: 9510
Advantage: 58

ShangHai Caerulum Pharma Discovery Co., Ltd.

Tel: 18149758185
Email: sales-cpd@caerulumpharma.com
Country: China
ProdList: 3506
Advantage: 58

ChemStrong Scientific Co.,Ltd

Tel: 0755-0755-66853366 13670046396
Fax: 0755-28363542
Email: sales@chem-strong.com
Country: China
ProdList: 18333
Advantage: 56

Cool Pharm, Ltd

Tel: 021-60455363 18019463053
Fax: 50966098
Email: sales@coolpharm.com
Country: China
ProdList: 12346
Advantage: 58

Shanghai YuanQi Biotechnology Co., Ltd.

Tel: +86-2332782371 +86-18120098618
Email: sales@adobechem.com
Country: China
ProdList: 1250
Advantage: 50

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4757
Advantage: 55

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View Lastest Price from LOXO-195 manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: LOXO-195 2097002-61-2
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1ton
Release date: 2022-09-29

Dideu Industries Group Limited

Product: LOXO-195 2097002-61-2
Price: US $1.10/g
Min. Order: 1g
Purity: 99.9%
Supply Ability: 100 Tons min
Release date: 2021-08-18

2097002-61-2, LOXO-195Related Search:

Repotrectinib LOXO-292 Entrectinib LOXO-195 NVP-BKM120 (Hydrochloride) Crizotinib Lorlatinib (PF-06463922)

(3aR,10R)-5-Fluoro-1,2,3,3a,8,9,10,11-octahydro-10-methyl-12H-15,17-ethenopyrazolo[3,4-d]pyrido[2,3-k]pyrrolo[2,1-m][1,3,7]triazacyclotridecin-12-one

selitrectinib（LOXO-195）

CS-2800

LOXO-195;LOXO195

Selitrectinib

LOXO 195(Selitrectinib)

Selitrectinib (Synonyms: LOXO-195)

12H-15,17-Ethenopyrazolo[3,4-d]pyrido[2,3-k]pyrrolo[2,1-m][1,3,7]triazacyclotridecin-12-one, 5-fluoro-1,2,3,3a,8,9,10,11-octahydro-10-methyl-, (3aR,10R)-

LOXO-195 USP/EP/BP

Selitrectinib (BAY 2731954

LOXO-195(3aR,10R)

LOXO-195(Slitrecrinib)

Selitrectinib, 10 mM in DMSO

Selitrectinib (LOXO-195) ，S8636

(13e,14e,22r,6r)-35-fluoro-6-methyl-7-aza-1(5,3)-pyrazolo[1,5-a]pyrimidina-3(3,2)-pyridina-2(1,2)-pyrrolidinacyclooctaphan-8-one

2097002-61-2