ChemicalBook > CAS DataBase List > Buparlisib Hydrochloride

Buparlisib Hydrochloride

Product Name: Buparlisib Hydrochloride
CAS No.: 1312445-63-8
Chemical Name: Buparlisib Hydrochloride
Synonyms: CS-2154;BKM 120AAA;NVP-BKM120 HCl;Buparlisib HCl;BKM-120 (HCl salt);NVP-BKM120 HCl salt;BKM120 hydrochloride;BKM-120 hydrochloride;BKM 120 hydrochloride;NVP-BKM120 (HYDROCHLORI
CBNumber: CB72624269
Molecular Formula: C18H22ClF3N6O2
Formula Weight: 446.86
MOL File: 1312445-63-8.mol

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Buparlisib Hydrochloride Property

storage temp.: Store at -20°C
solubility: ≥44.7 mg/mL in DMSO; ≥52.8 mg/mL in H2O with gentle warming; ≥96 mg/mL in EtOH with gentle warming
form: solid
color: White to yellow
InChI: InChI=1S/C18H21F3N6O2.ClH/c19-18(20,21)13-9-15(22)23-11-12(13)14-10-16(26-1-5-28-6-2-26)25-17(24-14)27-3-7-29-8-4-27;/h9-11H,1-8H2,(H2,22,23);1H
InChIKey: DGPLYAXBXJXEID-UHFFFAOYSA-N
SMILES: C(C1=CC(N)=NC=C1C1=NC(N2CCOCC2)=NC(N2CCOCC2)=C1)(F)(F)F.Cl

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H300Fatal if swallowed

H341Suspected of causing genetic defects

H372Causes damage to organs through prolonged or repeated exposure

H400Very toxic to aquatic life

H411Toxic to aquatic life with long lasting effects

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P273Avoid release to the environment.

P281Use personal protective equipment as required.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P308+P313IF exposed or concerned: Get medical advice/attention.

P314Get medical advice/attention if you feel unwell.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P391Collect spillage. Hazardous to the aquatic environment

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0820
Product name: BuparlisibHydrochloride
Purity: 99.79%
Packaging: 5mg
Price: $72
Updated: 2021/12/16

ApexBio Technology

Product number: A3674
Product name: NVP-BKM120Hydrochloride
Packaging: 5mg
Price: $90
Updated: 2021/12/16

ChemScene

Product number: CS-0820
Product name: BuparlisibHydrochloride
Purity: 99.79%
Packaging: 10mg
Price: $108
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb611812
Product name: NVP-BKM120 hydrochloride
Packaging: 10mg
Price: $210.8
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: KIN0001499
Product name: BKM-120 HYDROCHLORIDE
Purity: 95.00%
Packaging: 10MG
Price: $253.05
Updated: 2021/12/16

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Buparlisib Hydrochloride Chemical Properties,Usage,Production

Uses

NVP-BKM 120-d16 Hydrochloride is the salt, labeled analogue of NVP-BKM 120 (N925760), a novel anti-tumor active compound that is selective in that it inhibits specifically PI3 kinase activating cell death in glioma cells. Glioma cells being those that proliferate from tumors in the brain or the spine.

Definition

Buparlisib hydrochloride (BKM120 Hydrochloride) is an investigational small molecule orally available pan-class I phosphoinositide 3-kinase inhibitor, with IC50 of 52 nM/166 nM/116 nM/262 nM for p110α/p110β/p110δ/p110γ, respectively.

Mode of action

Buparlisib specifically inhibits class I PIK3 in the PI3K/AKT kinase signaling pathway in an ATP-competitive manner, thus inhibiting the production of the secondary messenger phosphatidylinositol (3,4,5)-trisphosphate and activation of the PI3K signaling pathway. This may induce inhibition of tumour cell growth and survival in susceptible tumour cell populations. Buparlisib is currently under investigation in patients with a variety of solid tumours, including breast cancer[1].

References

[1] Carmen Criscitiello. “Profile of buparlisib and its potential in the treatment of breast cancer: evidence to date.” Breast Cancer?: Targets and Therapy 10 (2018): 23–29.

Buparlisib Hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Buparlisib Hydrochloride manufacturers

Career Henan Chemical Co

Product: NVP-BKM120 (Hydrochloride) 1312445-63-8
Price: US $2.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: ask
Release date: 2018-12-23

1312445-63-8, Buparlisib HydrochlorideRelated Search:

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NVP-BKM120 (Hydrochloride)

BKM 120 hydrochloride

BKM120 hydrochloride

BKM-120 hydrochloride

5-(2,6-DiMorpholinopyriMidin-4-yl)-4-(trifluoroMethyl)pyridin-2-aMine hydrochloride

5-(2,6-Di-4-morpholinyl-4-pyrimidinyl)-4-(trifluoromethyl)-2-pyridinamine hydrochloride (1:1)

BKM 120AAA

Buparlisib hydrochloride

NVP-BKM120 HCl

NVP-BKM120 HCl salt

BKM-120 (HCl salt)

NVP-BKM120 (HYDROCHLORI

CS-2154

BKM-120 HYDROCHLORIDE;BUPARLISIB HYDROCHLORIDE

BKM-120 HYDROCHLORIDE; BKM120 HYDROCHLORIDE; BKM 120 HYDROCHLORIDE

Buparlisib HCl

BKM120 HCl (Buparlisib)

NVP-BKM120 Hydrochloride (Buparlisib HCl)

1312445-63-8

C18H22ClF3N6O2

C18H21F3N6O2HCl

API