ChemicalBook > CAS DataBase List > LOXO-195

LOXO-195

Product Name: LOXO-195
CAS No.: 1350884-56-8
Chemical Name: LOXO-195
Synonyms: LOXO-195;LOXO-195(3aR);(6RS)-LOXO-195;LOXO195 R racemic;LOXO-195, 10 mM in DMSO;Selitrectinib Racemate;Selitrectinib(LOXO-195) Racemate;(18bR)-17-Fluoro-1,2,3,11,12,13,14,18b-octahydro-12-methyl-10H-5,7-ethenopyrazolo[3,4-d]pyrido[2,3-k]pyrrolo[2,1-m][1,3,7]triazacyclotridecin-10-one;12H-15,17-Ethenopyrazolo[3,4-d]pyrido[2,3-k]pyrrolo[2,1-m][1,3,7]triazacyclotridecin-12-one, 5-fluoro-1,2,3,3a,8,9,10,11-octahydro-10-methyl-, (3aR)-
CBNumber: CB73311672
Molecular Formula: C20H21FN6O
Formula Weight: 380.42
MOL File: 1350884-56-8.mol

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LOXO-195 Property

Density: 1.51±0.1 g/cm3(Predicted)
pka: 11.44±0.40(Predicted)
InChI: InChI=1S/C20H21FN6O/c1-12-4-5-16-14(9-13(21)10-22-16)17-3-2-7-26(17)18-6-8-27-19(25-18)15(11-23-27)20(28)24-12/h6,8-12,17H,2-5,7H2,1H3,(H,24,28)/t12?,17-/m1/s1
InChIKey: OEBIHOVSAMBXIB-RGUGMKFQSA-N
SMILES: N12CCC[C@]1([H])C1=CC(F)=CN=C1CCC(C)NC(=O)C1C=NN3C=CC2=NC=13

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Usbiological

Product number: 453924
Product name: LOXO-195
Packaging: 1mg
Price: $496
Updated: 2021/12/16

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LOXO-195 Chemical Properties,Usage,Production

Description

LOXO-195 is an orally available, highly potent, and selective TRK kinase inhibitor designed to overcome drug resistance mediated by acquired mutations. Although responses to TRK inhibition can be dramatic and durable; however, eventually emergence of acquired resistance is found to be inevitable.

Uses

(3aR)-Selitrectinib ((3aR)-LOXO-195) is an isform of Selitrectinib (HY-101977), which is a next-generation TRK kinase inhibitor, with IC50s of 0.6 nM and <2.5 nM for TRKA and TRKC, respectively[1].

References

[1] Drilon A, et al. A Next-Generation TRK Kinase Inhibitor Overcomes Acquired Resistance to Prior TRK Kinase Inhibition in Patients with TRK Fusion-Positive Solid Tumors. Cancer Discov. 2017 Sep;7(9):963-972. DOI:10.1158/2159-8290.CD-17-0507

LOXO-195 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from LOXO-195 manufacturers

Career Henan Chemical Co

Product: LOXO-195 1350884-56-8
Price: US $2.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 100g , 1kg, 5kg , 50kg
Release date: 2020-01-07

1350884-56-8, LOXO-195Related Search:

Repotrectinib Entrectinib LOXO-195 NVP-BKM120 (Hydrochloride) Crizotinib Lorlatinib (PF-06463922)

LOXO-195

(18bR)-17-Fluoro-1,2,3,11,12,13,14,18b-octahydro-12-methyl-10H-5,7-ethenopyrazolo[3,4-d]pyrido[2,3-k]pyrrolo[2,1-m][1,3,7]triazacyclotridecin-10-one

Selitrectinib Racemate

(6RS)-LOXO-195

Selitrectinib(LOXO-195) Racemate

12H-15,17-Ethenopyrazolo[3,4-d]pyrido[2,3-k]pyrrolo[2,1-m][1,3,7]triazacyclotridecin-12-one, 5-fluoro-1,2,3,3a,8,9,10,11-octahydro-10-methyl-, (3aR)-

LOXO195 R racemic

LOXO-195(3aR)

LOXO-195, 10 mM in DMSO

1350884-56-8