ChemicalBook > CAS DataBase List > CSF1R-IN-2

CSF1R-IN-2

Product Name
CSF1R-IN-2
CAS No.
2271119-26-5
Chemical Name
CSF1R-IN-2
Synonyms
TPX-0022;CSF1R-IN-2;Elzovantinib;CSF1R inhibitor 2;TPX-0022(CSF1R-IN-2);Elzovantinib (TPX-0022);CSF1R-IN-2, 10 mM in DMSO;Elzovantinib (TPX-0022) ，S9620;Elzovantinib (TPX-0022, CSF1R-IN-2);colony stimulating factor 1 receptor,CSF-1R,CSF1R IN 2,inhibit,CSF1RIN2,c-Met/HGFR,CSF1R,CSF-1R-IN-2,Inhibitor,CSF-1 receptor,Src,c-Fms
CBNumber
CB95848846
Molecular Formula
C20H20FN7O2
Formula Weight
409.42
MOL File
2271119-26-5.mol
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CSF1R-IN-2 Property

storage temp. 
Store at -20°C
solubility 
DMSO : 25 mg/mL (61.06 mM; Need ultrasonic)
form 
A solid
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0091874
Product name
CSF1R-IN-2
Purity
99.97%
Packaging
5mg
Price
$350
Updated
2021/12/16
ChemScene
Product number
CS-0091874
Product name
CSF1R-IN-2
Purity
99.97%
Packaging
10mg
Price
$550
Updated
2021/12/16
ChemScene
Product number
CS-0091874
Product name
CSF1R-IN-2
Purity
99.97%
Packaging
50mg
Price
$1650
Updated
2021/12/16
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CSF1R-IN-2 Chemical Properties,Usage,Production

Uses

Elzovantinib (TPX-0022) is an oral-active inhibitor of SRC, MET and c-FMS, with IC50 values of 0.12 nM, 0.14 nM and 0.76 nM for SRC, MET and c-FMS respectively[1].

in vivo

Elzovantinib (TPX-0022; p.o., BID, 13 days) treatment results in an 85% tumor regression and no body weight loss is observed after 21 days treatment in mice[1].
Elzovantinib (p.o., BID, 10 days) demonstrates the ability to inhibit tumor growth at 44% and 67% at the dose of 5 mg/kg, BID and 15 mg/kg, BID, respectively in SCID/Beige mice[1].
Elzovantinib inhibits MET activity in MKN-45 tumors following oral administration in mice[1].

Animal Model:Mice bearing LU2503 tumors patient derived xenograft (PDX) NSCLC model[1].
Dosage:15 mg/kg.
Administration:PO, BID (twice daily) for 13 days.
Result:Resulted in an 85% tumor regression and no body weight loss was observed after 21 days treatment.
Animal Model:SCID/Beige mice bearing Ba/F3 ETV6-CSF1R tumors with average tumor size of ~180 mm3[1].
Dosage:5 and 15 mg/kg.
Administration:PO, BID (twice daily) for 10 days.
Result:Demonstrated the ability to inhibit tumor growth at 44% and 67% at the dose of 5 mg/kg, BID and 15 mg/kg, BID, respectively.

References

[1] WO 2019023417 A1.

CSF1R-IN-2 Preparation Products And Raw materials

Raw materials

Preparation Products

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CSF1R-IN-2 Suppliers

China 44 United States 3 Global 47
ShangHai Caerulum Pharma Discovery Co., Ltd.
Tel
18149758185 18149758185
Email
sales-cpd@caerulumpharma.com
Country
China
ProdList
3505
Advantage
58
Bide Pharmatech Ltd.
Tel
400-400-164-7117 18317119277
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
40000
Advantage
60
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4817
Advantage
55
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
86249
Advantage
60
ShangHai Biochempartner Co.,Ltd
Tel
177-54423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
8000
Advantage
62
Shanghai Rechem science Co., Ltd.
Tel
021-31433387 15618786686
Fax
QQ:1369748377
Email
sales@rechemscience.com
Country
China
ProdList
2990
Advantage
58
Shanghai Yunpun industrial Co.,Ltd
Tel
21-61726900 15202122459
Fax
+86-21-60277507
Email
sales@yunpun.com
Country
China
ProdList
494
Advantage
58
Chuzhou KeMail Chemical Technology Co., Ltd
Tel
0550-5196001 15000891977
Fax
0550-5196001
Email
wj520wjxby@126.com
Country
China
ProdList
1946
Advantage
55
Kaixin Chemical (Hong Kong) Limited
Tel
010-88886666-01 13112345678
Fax
CDXH21@126.com
Email
loyson@tcypharm.com
Country
China
ProdList
597
Advantage
55
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32467
Advantage
58

2271119-26-5, CSF1R-IN-2Related Search:

Repotrectinib TPX-0131 17,19-Metheno-1H,5H-cyclopent[5,6][1,4]oxazino[3,4-i]pyrazolo[4,3-f]pyrido[3,2-l][1,4,8,10]oxatriazacyclotridecin-14(11H)-one, 7-fluoro-2,3,3a,12,13,20a-hexahydro-11-methyl-, (3aS,11R,20aR)- TPX-0046

  • CSF1R-IN-2
  • CSF1R inhibitor 2
  • 1,15-Etheno-1H-pyrazolo[4,3-f][1,4,8,10]benzoxatriazacyclotridecine-12-carbonitrile, 3-amino-14-ethyl-11-fluoro-4,5,6,7,13,14-hexahydro-7-methyl-4-oxo-, (7S)-
  • TPX-0022
  • TPX-0022(CSF1R-IN-2)
  • Elzovantinib (TPX-0022)
  • colony stimulating factor 1 receptor,CSF-1R,CSF1R IN 2,inhibit,CSF1RIN2,c-Met/HGFR,CSF1R,CSF-1R-IN-2,Inhibitor,CSF-1 receptor,Src,c-Fms
  • Elzovantinib
  • (S)-12-Amino-2-ethyl-45-fluoro-6-methyl-9-oxo-5-oxa-2,8-diaza-1(5,3)-pyrazolo[1,5-a]pyrimidina-4(1,2)-benzenacyclononaphane-46-carbonitrile
  • CSF1R-IN-2, 10 mM in DMSO
  • Elzovantinib (TPX-0022, CSF1R-IN-2)
  • Elzovantinib (TPX-0022) ，S9620
  • 2271119-26-5