PDPN antibody
Applications Immunogen Background- Product Name
- PDPN antibody
- Chemical Name
- PDPN antibody
- Synonyms
- PDPN antibody;Rabbit Polyclonal PDPN Antibody
- CBNumber
- CB96084348
- Formula Weight
- 0
- MOL File
- Mol file
N-Bromosuccinimide Price
- Product number
- orb22898
- Product name
- PDPN antibody
- Purity
- Protein-G affinity chromatography.
- Packaging
- 5μg
- Price
- $205.7
- Updated
- 2021/12/16
- Product number
- orb22898
- Product name
- PDPN antibody
- Purity
- Protein-G affinity chromatography.
- Packaging
- 20μg
- Price
- $401.2
- Updated
- 2021/12/16
- Product number
- orb20288
- Product name
- PDPN antibody
- Purity
- Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
- Packaging
- 100μg
- Price
- $499.8
- Updated
- 2021/12/16
- Product number
- orb22898
- Product name
- PDPN antibody
- Purity
- Protein-G affinity chromatography.
- Packaging
- 100μg
- Price
- $737.8
- Updated
- 2021/12/16
PDPN antibody Chemical Properties,Usage,Production
Applications
PDPN antibody has been tested by ELISA and Western blot analysis to assure specificity and reactivity. Recommended dilution range for Western blot analysis is 1:500 ~ 1,000. Recommended starting dilution is 1:500.
Immunogen
Anti-human PDPN mAb is derived from hybridization of mouse FO myeloma cells with spleen cells from BALB/c mice immunized with recombinant human PDPN amino acids 1-206 purified from E. coli.
Background
Podoplanin is a small mucin-like type-1 transmembrane protein, typically expressed in various specialized cell types throughout the body. Podoplanin is a type-I integral membrane glycoprotein with diverse distribution in human tissues. PDPN physiological function is related to its mucin-type character. The homologous protein in other species has been described as a differentiation antigen and influenza-virus receptor.
PDPN is expressed in lymphatic progenitor cells and afterwards during mouse development in lymphatic endothelial cells. Podoplanin is a specific marker for lymph vessel endothelial cells. Over-expression of podoplanin significantly elevates endothelial cell adhesion, migration, and tube formation. Inhibition of Podoplanin expression decreases cell adhesion in human dermal lymphatic endothelial cells. Podoplanin is used as a specific marker for lymphatic endothelium in histopathology.
Podoplanin expression is increased in nearly all human colon, rectum, and small intestine tumors. AGGRUS may serve as a diagnostic marker that distinguishes seminomas, the majority of which over express the protein, from embryonal carcinoma in testicular germ cell tumors.
PDPN antibody Preparation Products And Raw materials
Raw materials
Preparation Products
PDPN antibody Suppliers
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