Bulevirtide

Product Name: Bulevirtide
CAS No.: 2012558-47-1
Chemical Name: Bulevirtide
Synonyms: MyrB;Bulevirtide;Propofol Impurity 48;Bulevirtide (Myrcludex B);{Myr}-Gly-Thr-Asn-Leu-Ser-Val-Pro-Asn-Pro-Leu-Gly-Phe-Phe-Pro-Asp-His-Gln-Leu-Asp-Pro-Ala-Phe-Gly-Ala-Asn-Ser-Asn-Asn-Pro-Asp-Trp-Asp-Phe-Asn-Pro-Asn-Lys-Asp-His-Trp-Pro-Glu-Ala-Asn-Lys-Val-Gly-NH2
CBNumber: CB96185223
Formula Weight: 0
MOL File: Mol file

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Bulevirtide Property

form: Solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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Bulevirtide Chemical Properties,Usage,Production

Description

Bulevirtide (BLV), the first-in-class entry inhibitor, is a 47-amino acid synthetic liner lipopeptide derived from the preS1 domain of the HBV large surface that targets the NTCP, the entry receptor for HBV/HDV. By blocking this receptor, new infections are prevented, and infected hepatocytes are replaced by naive cells that will be protected from infection. Consequently, viral spread in the liver is prevented.

Biological Activity

The sequence of Bulevirtide (BLV) is derived from that of preS1 from HBV genotype C (residues Gly2-Gly48) with a shortening of the 11 additional N-terminal amino acids and one amino acid substitution, Gln46Lys. BLV exhibits a remarkably high inhibitory constant (IC50?=?140 pM) against HBV and HDV in primary human hepatocytes and HepaRG cells. BLV has also been demonstrated to inhibit the NTCP-mediated uptake of bile salts but at an IC50 in the nanomolar range[1].

References

[1] Liu, Hongtao et al. “Structure of antiviral drug bulevirtide bound to hepatitis B and D virus receptor protein NTCP.” Nature Communications 22 1 (2024).

Bulevirtide Preparation Products And Raw materials

Raw materials

Preparation Products

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Bulevirtide Suppliers

China 26 United States 3 Global 29

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9806
Advantage: 58

ShangHai Biochempartner Co.,Ltd

Tel: 177-54423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 8011
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Shanghai Chaolan Chemical Technology Center

Tel: 021-QQ：65489617 15618227136
Fax: 21-5161 9052
Email: Sales@ATKchemical.com
Country: China
ProdList: 7298
Advantage: 58

Hangzhou Peptidego Biotech Co.,Ltd.

Tel: 0571-87213919
Fax: 0571-87213919
Email: Eric@peptidego.com
Country: China
ProdList: 6968
Advantage: 58

BOC Sciences

Tel: 16314854226; +16314854226
Email: inquiry@bocsci.com
Country: United States
ProdList: 19741
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Zhejiang J&C Biological Technology Co.,Limited

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Email: sales@sarms4muscle.com
Country: China
ProdList: 10473
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Wuxi Helen Biotechnology Co., Ltd.,

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Hangzhou Go Top Peptide Biotech

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Email: sales1@gotopbio.com
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InvivoChem

Tel: 13549236410
Email: sales@invivochem.cn
Country: China
ProdList: 6753
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Zhangzhou Sinobioway Peptide Co. Ltd.

Tel: 18750546777
Email: SINOPEPT@GMAIL.COM
Country: China
ProdList: 6068
Advantage: 58

2012558-47-1, BulevirtideRelated Search:

Bulevirtide

Bulevirtide (Myrcludex B)

MyrB

{Myr}-Gly-Thr-Asn-Leu-Ser-Val-Pro-Asn-Pro-Leu-Gly-Phe-Phe-Pro-Asp-His-Gln-Leu-Asp-Pro-Ala-Phe-Gly-Ala-Asn-Ser-Asn-Asn-Pro-Asp-Trp-Asp-Phe-Asn-Pro-Asn-Lys-Asp-His-Trp-Pro-Glu-Ala-Asn-Lys-Val-Gly-NH2

Propofol Impurity 48

2012558-47-1