Dihydrostreptomycin

Product Name: Dihydrostreptomycin
CAS No.: 128-46-1
Chemical Name: Dihydrostreptomycin
Synonyms: DHSM;dhms;abiocine;vibriomycin;DIHYDROSTREPTOMYCIN;dihydro-streptomyci;DihydroestreptoMycin Sulfate;Benzimidazole, 2-cyanomethyl;dihydrostreptomycine sulphate;Dihydrostreptomycin USP/EP/BP
CBNumber: CB9665040
Molecular Formula: C21H41N7O12
Formula Weight: 583.59
MOL File: 128-46-1.mol

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Dihydrostreptomycin Property

Melting point:: >300 °C
Boiling point:: 641.09°C (rough estimate)
Density: 1.3963 (rough estimate)
refractive index: 1.6800 (estimate)
pka: pKa 7.8 (Uncertain)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Usbiological

Product number: D8035
Product name: Dihydrostreptomycin
Packaging: 100g
Price: $72
Updated: 2021/12/16

Usbiological

Product number: 257286
Product name: Dihydrostreptomycin
Packaging: 50g
Price: $470
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0014251
Product name: DIHYDROSTREPTOMYCIN
Purity: 95.00%
Packaging: 1G
Price: $1358.28
Updated: 2021/12/16

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Dihydrostreptomycin Chemical Properties,Usage,Production

Description

Dihydrostreptomycin was first synthesized by Parke Davis Co. in 1946by the reduction of streptomycin. Naturally occurring dihydrostreptomycin was found in the culture broth of Streptomyces humidus by Takeda Chemicals Industries in 1957. Its hydrochloride or sulfate is more easily crystallized and more stable under alkaline conditions than streptomycin. Dihydrostreptomycin has been used for therapy of tuberculosis, but because it has a higher ototoxicity than streptomycin its use is now restricted to animal therapy.

Originator

Dihydrostrepto,MSD ,US,1948

Uses

Antibacterial.

Definition

ChEBI: Dihydrostreptomycin is a member of streptomycins.

Manufacturing Process

Dihydrostreptomycin sulfate may be prepared from streptomycin sulfate by catalytic hydrogenation (Merck, Pfizer, Cyanamid), electrolytic reduction (Schenley, Olin Mathieson), or by sodium borohydride reduction (Bristol), or by isolation from a fermentation process (Takeda).

brand name

Abocillin;Biostrep;Complexobiotico;Diapenin 3;Diapenin balsamico;Diarrestival;Didromycin;Didrothenate;Dihydrocidan sulfato;Dihydrostreptofar;Diidro-pantostrept;Distreptopab;Dreiciclina balsamica;Dst;Entera-strept;Estreptoluy;Estreptosirup;Helle-strep-forte;Hp 48;Mastigun;Mixtencillin;Retromyopen;Rocopenstrep;Sanstrepto;Solmycin;Solvo-strept;Streptoduocin;Veticar;Veycil-as.

Therapeutic Function

Antibiotic

World Health Organization (WHO)

Dihydrostreptomycin, a derivative of the aminoglycoside antibiotic streptomycin with similar antibacterial activity, was first synthesized in 1947 and subsequently used in the treatment of tuberculosis and gram-negative infections. Preparations for systemic use have been widely withdrawn as a result of concern regarding their severe ototoxicity. Dihydrostreptomycin is poorly absorbed from the gastrointestinal tract. It remains available in oral preparations in some countries.

Safety Profile

Poison by intravenous and intramuscular routes. Moderately toxic by subcutaneous and intraperitoneal routes. Human teratogenic effects by unspecified route: developmental abnormahties of the eye and ear. An experimental teratogen. Other experimental reproductive effects. Mutation data reported. A derivative of streptomycin; has anesthetic properties. When heated to decomposition it emits toxic fumes of NOx

Dihydrostreptomycin Preparation Products And Raw materials

Raw materials

Preparation Products

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Dihydrostreptomycin Suppliers

China 30 Europe 2 Germany 1 India 1 Switzerland 1 United Kingdom 1 United States 10 Global 46

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View Lastest Price from Dihydrostreptomycin manufacturers

Career Henan Chemical Co

Product: Dihydrostreptomycin 128-46-1
Price: US $1.00/g
Min. Order: 1g
Purity: ≥98%
Supply Ability: g/kg/Ton
Release date: 2019-12-25

128-46-1, DihydrostreptomycinRelated Search:

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DIHYDROSTREPTOMYCIN

Dihydrostreptomycin (base and/or unspecified salts)

2-[(1S,3R,4S,5R,6R)-5-(Diaminomethylideneamino)-2-[(2R,3R,4R,5S)-3-[(2S,3S,4S,5R,6S)-4,5-dihydroxy-6-(hydroxymethyl)-3-methylaminooxan-2-yl]oxy-4-hydroxy-4-(hydroxymethyl)-5-methyloxolan-2-yl]oxy-3,4,6-trihydroxycyclohexyl]guanidine

2-[(1R,2R,3S,4R,5R,6S)-3-(diaminomethylideneamino)-4-[(2R,3R,4R,5S)-3-[(2S,3S,4S,5R,6S)-4,5-dihydroxy-6-(hydroxymethyl)-3-(methylamino)oxan-2-yl]oxy-4-hydroxy-4-(hydroxymethyl)-5-methyloxolan-2-yl]oxy-2,5,6-trihydroxycyclohexyl]guanidine

Acetonitrile, 2-benzimidazolyl-

Benzimidazole, 2-cyanomethyl

4-O-[2-O-[2-(Methylamino)-2-deoxy-α-L-glucopyranosyl]-5-deoxy-3-hydroxymethyl-α-L-lyxofuranosyl]-N,N'-bis(aminoiminomethyl)-D-streptamine

DHSM

DihydroestreptoMycin Sulfate

2)-O-5-deoxy-3-C-(hydroxyMethyl)-a-L-lyxofuranosyl-(1&reg

4)-N1,N3-bis(aMinoiMinoMethyl)-

D-StreptaMine,O-2-deoxy-2-(MethylaMino)-a-L-glucopyranosyl-(1&reg

dihydrostreptomycine sulphate

DihydrostreptomycineSulphateSterileUsp26

D-Streptamine, O-2-deoxy-2-(methylamino)-.alpha.-L-glucopyranosyl-(1?2)-O-5-deoxy-3-C-(hydroxymethyl)-.alpha.-L-lyxofuranosyl-(1?4)-N,N-bis(aminoiminomethyl)-

abiocine

dhms

dihydro-streptomyci

vibriomycin

D-Streptamine, O-2-deoxy-2-(methylamino)-α-L-glucopyranosyl-(1→2)-O-5-deoxy-3-C-(hydroxymethyl)-α-L-lyxofuranosyl-(1→4)-N1,N3-bis(aminoiminomethyl)-

Dihydrostreptomycin USP/EP/BP

128-46-1

C21H41N7O12