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Dihydrostreptomycin

Product Name
Dihydrostreptomycin
CAS No.
128-46-1
Chemical Name
Dihydrostreptomycin
Synonyms
DHSM;dhms;abiocine;vibriomycin;DIHYDROSTREPTOMYCIN;dihydro-streptomyci;DihydroestreptoMycin Sulfate;Benzimidazole, 2-cyanomethyl;dihydrostreptomycine sulphate;Dihydrostreptomycin USP/EP/BP
CBNumber
CB9665040
Molecular Formula
C21H41N7O12
Formula Weight
583.59
MOL File
128-46-1.mol
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Dihydrostreptomycin Property

Melting point:
>300 °C
Boiling point:
641.09°C (rough estimate)
Density 
1.3963 (rough estimate)
refractive index 
1.6800 (estimate)
pka
pKa 7.8 (Uncertain)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Usbiological
Product number
D8035
Product name
Dihydrostreptomycin
Packaging
100g
Price
$72
Updated
2021/12/16
Usbiological
Product number
257286
Product name
Dihydrostreptomycin
Packaging
50g
Price
$470
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0014251
Product name
DIHYDROSTREPTOMYCIN
Purity
95.00%
Packaging
1G
Price
$1358.28
Updated
2021/12/16
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Dihydrostreptomycin Chemical Properties,Usage,Production

Description

Dihydrostreptomycin was first synthesized by Parke Davis Co. in 1946by the reduction of streptomycin. Naturally occurring dihydrostreptomycin was found in the culture broth of Streptomyces humidus by Takeda Chemicals Industries in 1957. Its hydrochloride or sulfate is more easily crystallized and more stable under alkaline conditions than streptomycin. Dihydrostreptomycin has been used for therapy of tuberculosis, but because it has a higher ototoxicity than streptomycin its use is now restricted to animal therapy.

Originator

Dihydrostrepto,MSD ,US,1948

Uses

Antibacterial.

Definition

ChEBI: Dihydrostreptomycin is a member of streptomycins.

Manufacturing Process

Dihydrostreptomycin sulfate may be prepared from streptomycin sulfate by catalytic hydrogenation (Merck, Pfizer, Cyanamid), electrolytic reduction (Schenley, Olin Mathieson), or by sodium borohydride reduction (Bristol), or by isolation from a fermentation process (Takeda).

brand name

Abocillin;Biostrep;Complexobiotico;Diapenin 3;Diapenin balsamico;Diarrestival;Didromycin;Didrothenate;Dihydrocidan sulfato;Dihydrostreptofar;Diidro-pantostrept;Distreptopab;Dreiciclina balsamica;Dst;Entera-strept;Estreptoluy;Estreptosirup;Helle-strep-forte;Hp 48;Mastigun;Mixtencillin;Retromyopen;Rocopenstrep;Sanstrepto;Solmycin;Solvo-strept;Streptoduocin;Veticar;Veycil-as.

Therapeutic Function

Antibiotic

World Health Organization (WHO)

Dihydrostreptomycin, a derivative of the aminoglycoside antibiotic streptomycin with similar antibacterial activity, was first synthesized in 1947 and subsequently used in the treatment of tuberculosis and gram-negative infections. Preparations for systemic use have been widely withdrawn as a result of concern regarding their severe ototoxicity. Dihydrostreptomycin is poorly absorbed from the gastrointestinal tract. It remains available in oral preparations in some countries.

Safety Profile

Poison by intravenous and intramuscular routes. Moderately toxic by subcutaneous and intraperitoneal routes. Human teratogenic effects by unspecified route: developmental abnormahties of the eye and ear. An experimental teratogen. Other experimental reproductive effects. Mutation data reported. A derivative of streptomycin; has anesthetic properties. When heated to decomposition it emits toxic fumes of NOx

Dihydrostreptomycin Preparation Products And Raw materials

Raw materials

Preparation Products

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Dihydrostreptomycin Suppliers

Chizhou Kailong Import and Export Trade Co., Ltd.
Tel
Fax
-
Email
xg01_gj@163.com
Country
China
ProdList
9484
Advantage
50
Alta Scientific Co., Ltd.
Tel
022-6537-8550 15522853686
Fax
022-2532-9655
Email
sales@altasci.com.cn
Country
China
ProdList
4511
Advantage
55
BOC Sciences
Tel
16314854226; +16314854226
Email
inquiry@bocsci.com
Country
United States
ProdList
19741
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32161
Advantage
58
Dayang Chem (Hangzhou) Co.,Ltd.
Tel
571-88938639 +8617705817739
Fax
+86-571-88938652,+86-571- 88492614
Email
info@dycnchem.com
Country
China
ProdList
52849
Advantage
58
Shaanxi Dideu Medichem Co. Ltd
Tel
+86-029-89586680 +86-18192503167
Fax
+86-29-88380327
Email
1026@dideu.com
Country
China
ProdList
7724
Advantage
58
SIMAGCHEM CORP
Tel
+86-13806087780
Email
sale@simagchem.com
Country
China
ProdList
17365
Advantage
58
CONIER CHEM AND PHARMA LIMITED
Tel
+8618523575427
Email
sales@conier.com
Country
China
ProdList
49374
Advantage
58
career henan chemical co
Tel
+86-0371-86658258 +8613203830695
Fax
0086-371-86658258
Email
factory@coreychem.com
Country
China
ProdList
29811
Advantage
58
ShangHai Anpel Co, Ltd.
Tel
18501792038; 18501792038
Email
shanpel@anpel.com.cn
Country
China
ProdList
9611
Advantage
58
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View Lastest Price from Dihydrostreptomycin manufacturers

Career Henan Chemical Co
Product
Dihydrostreptomycin 128-46-1
Price
US $1.00/g
Min. Order
1g
Purity
≥98%
Supply Ability
g/kg/Ton
Release date
2019-12-25

128-46-1, DihydrostreptomycinRelated Search:


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  • 2-[(1S,3R,4S,5R,6R)-5-(Diaminomethylideneamino)-2-[(2R,3R,4R,5S)-3-[(2S,3S,4S,5R,6S)-4,5-dihydroxy-6-(hydroxymethyl)-3-methylaminooxan-2-yl]oxy-4-hydroxy-4-(hydroxymethyl)-5-methyloxolan-2-yl]oxy-3,4,6-trihydroxycyclohexyl]guanidine
  • 2-[(1R,2R,3S,4R,5R,6S)-3-(diaminomethylideneamino)-4-[(2R,3R,4R,5S)-3-[(2S,3S,4S,5R,6S)-4,5-dihydroxy-6-(hydroxymethyl)-3-(methylamino)oxan-2-yl]oxy-4-hydroxy-4-(hydroxymethyl)-5-methyloxolan-2-yl]oxy-2,5,6-trihydroxycyclohexyl]guanidine
  • Acetonitrile, 2-benzimidazolyl-
  • Benzimidazole, 2-cyanomethyl
  • 4-O-[2-O-[2-(Methylamino)-2-deoxy-α-L-glucopyranosyl]-5-deoxy-3-hydroxymethyl-α-L-lyxofuranosyl]-N,N'-bis(aminoiminomethyl)-D-streptamine
  • DHSM
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  • 4)-N1,N3-bis(aMinoiMinoMethyl)-
  • D-StreptaMine,O-2-deoxy-2-(MethylaMino)-a-L-glucopyranosyl-(1&reg
  • dihydrostreptomycine sulphate
  • DihydrostreptomycineSulphateSterileUsp26
  • D-Streptamine, O-2-deoxy-2-(methylamino)-.alpha.-L-glucopyranosyl-(1?2)-O-5-deoxy-3-C-(hydroxymethyl)-.alpha.-L-lyxofuranosyl-(1?4)-N,N-bis(aminoiminomethyl)-
  • abiocine
  • dhms
  • dihydro-streptomyci
  • vibriomycin
  • D-Streptamine, O-2-deoxy-2-(methylamino)-α-L-glucopyranosyl-(1→2)-O-5-deoxy-3-C-(hydroxymethyl)-α-L-lyxofuranosyl-(1→4)-N1,N3-bis(aminoiminomethyl)-
  • Dihydrostreptomycin USP/EP/BP
  • 128-46-1
  • C21H41N7O12