6-IODONORDIHYDROCAPSAICIN
- Product Name
- 6-IODONORDIHYDROCAPSAICIN
- CAS No.
- 859171-97-4
- Chemical Name
- 6-IODONORDIHYDROCAPSAICIN
- Synonyms
- 6'-Iodononivamide;6-IODONORDIHYDROCAPSAICIN;6-IODONORDIHYDROCAPSAICIN USP/EP/BP;Nonanamide, N-[(4-hydroxy-2-iodo-5-methoxyphenyl)methyl]-
- CBNumber
- CB9673887
- Molecular Formula
- C17H26INO3
- Formula Weight
- 419.3
- MOL File
- 859171-97-4.mol
6-IODONORDIHYDROCAPSAICIN Property
- Melting point:
- 106-107 °C(Solv: ethyl acetate (141-78-6); hexane (110-54-3))
- Boiling point:
- 552.9±50.0 °C(Predicted)
- Density
- 1.375±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- H2O: insoluble
- form
- solid
- pka
- 8.93±0.25(Predicted)
- color
- white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- I0909
- Product name
- 6-Iodonordihydrocapsaicin
- Purity
- ≥98% (HPLC), solid
- Packaging
- 25mg
- Price
- $150.8
- Updated
- 2024/03/01
- Product number
- I0909
- Product name
- 6-Iodonordihydrocapsaicin
- Purity
- ≥98% (HPLC), solid
- Packaging
- 5mg
- Price
- $118
- Updated
- 2022/05/15
- Product number
- I716005
- Product name
- 6-Iodonordihydrocapsaicin
- Packaging
- 2.5mg
- Price
- $195
- Updated
- 2021/12/16
- Product number
- 254440
- Product name
- 6-Iodonordihydrocapsaicin
- Packaging
- 10mg
- Price
- $423
- Updated
- 2021/12/16
- Product number
- B5245
- Product name
- 6-Iodonordihydrocapsaicin
- Packaging
- 25mg
- Price
- $511
- Updated
- 2021/12/16
6-IODONORDIHYDROCAPSAICIN Chemical Properties,Usage,Production
Uses
6-?iodonordihydrocapsaicin (6-?I-?CPS) is a weak ERα agonist. It was demonstrated to induce luciferase gene expression.
Definition
ChEBI: N-[(4-hydroxy-2-iodo-5-methoxyphenyl)methyl]nonanamide is a member of phenols and a member of methoxybenzenes.
Biological Activity
the vanilloid trpv1 receptor, also known as vr1 receptor, belongs to the large family of ‘transient receptor potential’ (trp). trpv1 functions as a molecular integrator of nociceptive stimuli, including heat, protons and plant toxins, and is most abundant in peripheral sensory fibers of the c and ad type. 6-iodo-nordihydrocapsaicin is a potent trpv1 antagonist.
in vitro
using human recombinant trpv1, 6-iodonordihydrocapsaicin (ic50=10 nm against 100 nm capsaicin) was about four times more potent than the prototypical trpv1 antagonist, capsazepine [1].
in vivo
6-iodonordihydrocapsaicin was tested against capsaicin also on native trpv1 in: (i) rat dorsal root ganglion neurons in culture; (ii) guinea-pig urinary bladder; and (iii) guinea-pig bronchi. in all cases, except for the guineapig bronchi, the compound was significantly more potent than capsazepine as a trpv1 antagonist [1].
IC 50
10 nm against 100 nm capsaicin
References
[1] appendino g, harrison s, de petrocellis l, daddario n, bianchi f, schiano moriello a, trevisani m, benvenuti f, geppetti p, di marzo v. halogenation of a capsaicin analogue leads to novel vanilloid trpv1 receptor antagonists. br j pharmacol. 2003 aug;139(8):1417-24.
6-IODONORDIHYDROCAPSAICIN Preparation Products And Raw materials
Raw materials
Preparation Products
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