ChemicalBook > CAS DataBase List > 3-(2-CHLORO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER

3-(2-CHLORO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER

Product Name: 3-(2-CHLORO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER
CAS No.: 19112-35-7
Chemical Name: 3-(2-CHLORO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER
Synonyms: NSC 158136;Ethyl (o-chlorobenzoyl)acetate;ETHYL (2-CHLOROBENZOYL)ACETATE;Ethyl (2-chlorobenzoyl)acetate >=95%;Ethyl 2-chloro-β-oxobenzenepropanoate;Ethyl 3-(2-Chlorophenyl)-3-oxopropionate;ETHYL 3-(2-CHLORO-PHENYL)-3-OXOPROPANOATE;Benzenepropanoic acid, 2-chloro-β-oxo-, ethyl ester;3-(2-CHLORO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER
CBNumber: CB9676424
Molecular Formula: C11H11ClO3
Formula Weight: 226.66
MOL File: 19112-35-7.mol

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3-(2-CHLORO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER Property

Boiling point:: 221-222 °C (lit.)
Density: 1.206 g/mL at 25 °C (lit.)
refractive index: n20/D 1.540(lit.)
Flash point:: >230 °F
storage temp.: Sealed in dry,Room Temperature
pka: 9.85±0.46(Predicted)
Appearance: Colorless to light yellow Liquid

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 559091
Product name: Ethyl (2-chlorobenzoyl)acetate
Purity: ≥95%
Packaging: 5g
Price: $221.2
Updated: 2025/07/31

Sigma-Aldrich

Product number: 559091
Product name: Ethyl (2-chlorobenzoyl)acetate
Purity: ≥95%
Packaging: 1g
Price: $128
Updated: 2023/06/20

TRC

Product number: E903775
Product name: Ethyl3-(2-Chlorophenyl)-3-oxopropanoate
Packaging: 10mg
Price: $45
Updated: 2021/12/16

TRC

Product number: E903775
Product name: Ethyl3-(2-Chlorophenyl)-3-oxopropanoate
Packaging: 50mg
Price: $60
Updated: 2021/12/16

AK Scientific

Product number: Z4345
Product name: Ethyl (2-chlorobenzoyl)acetate
Packaging: 1g
Price: $81
Updated: 2021/12/16

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3-(2-CHLORO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER Chemical Properties,Usage,Production

Uses

Reactant for:

Cerium ammonium nitrate-mediated oxidative coupling
Hydrosilylation reactions
Preparation of diaryl-substituted pyrazoles as potent CCR2 receptor antagonists
Preparation of potential herbicidal agents
Ruthenium-catalyzed asymmetric hydrogenation

Synthesis

6148-64-7

609-65-4

19112-35-7

GENERAL STEPS: EXPERIMENTAL OPERATION: Potassium monoethyl malonate salt (1.00 g, ~5.47 mmol) was taken in a 25 mL round bottom flask, anhydrous magnesium chloride (0.65 g, ~6.84 mmol) and acetonitrile (6 mL) were added, followed by the dropwise addition of triethylamine (0.55 g). The mixture was stirred at room temperature for 30 minutes. Next, a solution of o-chlorobenzoyl chloride (0.48 g, 2.5 mmol) dissolved in acetonitrile (2 mL) was slowly added dropwise and supplemented with triethylamine (0.06 mL), and stirring was continued at room temperature overnight. Post-treatment: after completion of the reaction, the reaction mixture was diluted with the addition of water (30 mL) and subsequently extracted with ethyl acetate (30 mL, 20 mL, 20 mL). The ethyl acetate layers were combined, washed with saturated brine and dried over anhydrous sodium sulfate. The dried organic phase was concentrated by rotary evaporation and finally purified by column chromatography (eluent: petroleum ether/ethyl acetate=15:1) to afford the target product (2-chlorobenzoyl)ethyl acetate in 91% yield.

References

[1] Patent: CN105566340, 2016, A. Location in patent: Paragraph 0010
[2] Patent: CN105663112, 2016, A. Location in patent: Page/Page column 12

3-(2-CHLORO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 3-(2-CHLORO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER manufacturers

Career Henan Chemical Co

Product: 3-(2-CHLORO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER 19112-35-7
Price: US $6.60/KG
Min. Order: 1KG
Purity: 97%-99%
Supply Ability: 1kg -1000kg
Release date: 2020-01-02

19112-35-7, 3-(2-CHLORO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTERRelated Search:

3-Methylquinoline Quincarbate ETHYL 2,4-DICHLORO-5-FLUOROBENZOYLACETATE 3-(4-CHLORO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER Ethyl (3-chlorobenzoyl)acetate 3-(2,4-DICHLORO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER (Z)-3-CYCLOPROPYLAMINO-2-(2,4-DICHLORO-5-FLUORO-BENZOYL)-ACRYLIC ACID ETHYL ESTER ethyl 3-(2,5-dichlorophenyl)-3-oxopropanoate 2,4,5-TRICHLORO-BETA-OXO-BENZENEPROPANOIC ACID ETHYL ESTER ETHYL 3-(2,6-DICHLOROPHENYL)-3-OXOPROPANOATE 2-(2,4-DICHLORO-5-FLUORO-BENZOYL)-MALONIC ACID DIETHYL ESTER 3-(2-CHLORO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER ETHYL 3-OXO-3-(2,3,4-TRICHLOROPHENYL)PROPANOATE AKOS 92243 AKOS 92395 3-(2-CHLORO-PHENYL)-2-CYANO-3-OXO-PROPIONIC ACID ETHYL ESTER AKOS MSC-0306 AKOS 1307

ETHYL (2-CHLOROBENZOYL)ACETATE

ETHYL 3-(2-CHLORO-PHENYL)-3-OXOPROPANOATE

3-(2-CHLORO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER

Ethyl (o-chlorobenzoyl)acetate

NSC 158136

Ethyl (2-chlorobenzoyl)acetate >=95%

Ethyl 3-(2-Chlorophenyl)-3-oxopropionate

Benzenepropanoic acid, 2-chloro-β-oxo-, ethyl ester

Ethyl 2-chloro-β-oxobenzenepropanoate

19112-35-7

Organic Building Blocks

Esters

Building Blocks

Carbonyl Compounds

C10 to C11

Carbonyl Compounds

Esters