4,6-DICHLORO-2-(METHYLTHIO)PYRIMIDINE-5-CARBOXYLIC ACID
- Product Name
- 4,6-DICHLORO-2-(METHYLTHIO)PYRIMIDINE-5-CARBOXYLIC ACID
- CAS No.
- 313339-35-4
- Chemical Name
- 4,6-DICHLORO-2-(METHYLTHIO)PYRIMIDINE-5-CARBOXYLIC ACID
- Synonyms
- RARECHEM AL BO 1988;4,6-dichloro-2-methylsulfanylpyrimidine-5-carboxylicaci;4,6-DICHLORO-2-(METHYLTHIO)PYRIMIDINE-5-CARBOXYLIC ACID;4,6-dichloro-2-(Methylthio)-5-pyriMidine carboxylic acid;5-Pyrimidinecarboxylic acid, 4,6-dichloro-2-(methylthio)-;4,6-dichloro-2-(Methylsulfanyl)pyriMidine-5-carboxylic acid;4,6-DICHLORO-2-(METHYLTHIO)PYRIMIDINE-5-CARBOXYLIC ACID ISO 9001：2015 REACH
- CBNumber
- CB9682186
- Molecular Formula
- C6H4Cl2N2O2S
- Formula Weight
- 239.08
- MOL File
- 313339-35-4.mol
4,6-DICHLORO-2-(METHYLTHIO)PYRIMIDINE-5-CARBOXYLIC ACID Property
- Melting point:
- 159-163 °C (D)
- Boiling point:
- 384.5±37.0 °C(Predicted)
- Density
- 1.71±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- solid
- pka
- 0.08±0.32(Predicted)
- Appearance
- Off-white to light yellow Solid
- InChI
- InChI=1S/C6H4Cl2N2O2S/c1-13-6-9-3(7)2(5(11)12)4(8)10-6/h1H3,(H,11,12)
- InChIKey
- LUCAXEBLTQAMHS-UHFFFAOYSA-N
- SMILES
- C1(SC)=NC(Cl)=C(C(O)=O)C(Cl)=N1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 718769
- Product name
- 4,6-Dichloro-2-(methylthio)pyrimidine-5-carboxylic acid
- Purity
- 97%
- Packaging
- 1g
- Price
- $149
- Updated
- 2023/06/20
- Product number
- D438523
- Product name
- 4,6-Dichloro-2-(methylthio)pyrimidine-5-carboxylic acid
- Packaging
- 100mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- FD35529
- Product name
- 4,6-Dichloro-2-(methylthio)pyrimidine-5-carboxylic acid
- Packaging
- 5G
- Price
- $85
- Updated
- 2021/12/16
- Product number
- 090233
- Product name
- 4,6-Dichloro-2-(methylthio)pyrimidine-5-carboxylic acid
- Purity
- 95+%
- Packaging
- 1g
- Price
- $124
- Updated
- 2021/12/16
- Product number
- FD35529
- Product name
- 4,6-Dichloro-2-(methylthio)pyrimidine-5-carboxylic acid
- Packaging
- 2g
- Price
- $50
- Updated
- 2021/12/16
4,6-DICHLORO-2-(METHYLTHIO)PYRIMIDINE-5-CARBOXYLIC ACID Chemical Properties,Usage,Production
Synthesis
6299-25-8
124-38-9
313339-35-4
1. 4,6-dichloro-2-methylthioalkylpyrimidine (1.00 g, 5.13 mmol) was dissolved in tetrahydrofuran (THF, 10 mL). 2. 2.0 M lithium diisopropylammonium (LDA) solution in THF (5.9 mL, 11.8 mmol) was added to the solution at -78 °C and stirred for 1 hour. 3. carbon dioxide gas (dry ice) was passed into the reaction mixture at -78 °C. 4. the reaction mixture was warmed to room temperature and stirring was continued for 1.5 hours. 5. Upon completion of the reaction, the organic layer was separated by adding 10% aqueous hydrochloric acid and ethyl acetate for extraction. 6. The organic layer was dried with anhydrous magnesium sulfate and concentrated under reduced pressure to remove the solvent. 7. The residue was re-slurried with hexane and the solid was collected by filtration to afford 2-(methylthio)-4,6-dichloropyrimidine-5-carboxylic acid (964 mg, 79% yield). 8. The product was passed through ESI-MSR. 8. The product was characterized by ESI-MS and 1H-NMR: ESI-MS m/z 237 [M-H]-; 1H-NMR (CDCl3) δ 2.60 (s, 3H), 9.68 (brs, 1H).
References
[1] Bioorganic and Medicinal Chemistry Letters, 2008, vol. 18, # 16, p. 4642 - 4646
[2] Patent: EP2163554, 2010, A1. Location in patent: Page/Page column 49
[3] Bioorganic and Medicinal Chemistry Letters, 2005, vol. 15, # 5, p. 1485 - 1488
[4] Bioorganic and Medicinal Chemistry, 2005, vol. 13, # 20, p. 5717 - 5732
[5] Patent: EP1496059, 2005, A1. Location in patent: Page 19-20
4,6-DICHLORO-2-(METHYLTHIO)PYRIMIDINE-5-CARBOXYLIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4,6-DICHLORO-2-(METHYLTHIO)PYRIMIDINE-5-CARBOXYLIC ACID manufacturers
- Product
- 4,6-DICHLORO-2-(METHYLTHIO)PYRIMIDINE-5-CARBOXYLIC ACID 313339-35-4
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.0% min
- Supply Ability
- 100 tons min
- Release date
- 2021-11-24
- Product
- 4,6-DICHLORO-2-(METHYLTHIO)PYRIMIDINE-5-CARBOXYLIC ACID 313339-35-4
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2019-12-25