ETHYL 2-(4-CHLOROPHENYLAMINO)-4-THIAZOLECARBOXYLATE
- Product Name
- ETHYL 2-(4-CHLOROPHENYLAMINO)-4-THIAZOLECARBOXYLATE
- CAS No.
- 165682-93-9
- Chemical Name
- ETHYL 2-(4-CHLOROPHENYLAMINO)-4-THIAZOLECARBOXYLATE
- Synonyms
- O4I2;O412;O4I2, >98%;O4I-2;O4I 2;O4I2 >=98% (HPLC);O4I2, 10 mM in DMSO;ethyl 2-(4-chlorophenylamino)thiazole-4-carboxylate;ETHYL 2-(4-CHLOROPHENYLAMINO)-4-THIAZOLECARBOXYLATE;ethyl 2-(4-chloroanilino)-1,3-thiazole-4-carboxylate;Ethyl 4-((4-chlorophenyl)amino)-3,5-thiazolecarboxylate
- CBNumber
- CB9689231
- Molecular Formula
- C12H11ClN2O2S
- Formula Weight
- 282.75
- MOL File
- 165682-93-9.mol
ETHYL 2-(4-CHLOROPHENYLAMINO)-4-THIAZOLECARBOXYLATE Property
- Boiling point:
- 408.1±51.0 °C(Predicted)
- Density
- 1.382±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- solubility
- DMSO:20.0(Max Conc. mg/mL);70.7(Max Conc. mM)
- form
- A crystalline solid
- pka
- 1.48±0.10(Predicted)
- color
- Light yellow to yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P322Specific measures (see …on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P363Wash contaminated clothing before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- SML1428
- Product name
- O4I2
- Purity
- ≥98% (HPLC)
- Packaging
- 25 mg
- Price
- $323
- Updated
- 2025/07/31
- Product number
- O0624
- Product name
- O4I2
- Packaging
- 25MG
- Price
- $270
- Updated
- 2025/07/31
- Product number
- 19135
- Product name
- O4I2
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 19135
- Product name
- O4I2
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $86
- Updated
- 2024/03/01
- Product number
- 19135
- Product name
- O4I2
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $117
- Updated
- 2024/03/01
ETHYL 2-(4-CHLOROPHENYLAMINO)-4-THIAZOLECARBOXYLATE Chemical Properties,Usage,Production
Uses
O4I2 is a potent inducer of Oct3/4 expression.
Biological Activity
O4I2 is a potent inducer of the Octamer-binding transcription factor 4 (Oct3/4) in various human cell lines including human fibroblasts. In principle O4I2 could be a useful tool for chemical-mediated induction of pluripotency in somatic cells.
Synthesis
70-23-5
3696-23-9
165682-93-9
GENERAL METHODOLOGY: General procedure for the preparation of ethyl 2-((4-chlorophenyl)amino)thiazole-4-carboxylate: a mixture of ethyl 3-bromopyruvate (2.14 g, 11 mmol) and 1-(4-chlorophenyl)thiourea (0.75 g, 10 mmol) was milled in the presence of Na2CO3 (0.50 g) for 5-6 min. The reaction process was monitored by TLC. After completion of the reaction, water (20 ml) was added to the reaction mixture and subsequently extracted with chloroform (20 ml). The separated organic layer was dried with anhydrous sodium sulfate. Excess solvent was removed by distillation. The crude product was filtered and crystallized from aqueous ethanol to give pure solid product in 83% yield. Similarly, other derivatives can be prepared according to the above method and their structures were confirmed by comparison of melting points with literature values.
storage
Store at -20°C
References
[1] Journal of Medicinal Chemistry, 2015, vol. 58, # 15, p. 5742 - 5750
[2] European Journal of Medicinal Chemistry, 2016, vol. 123, p. 718 - 726
[3] Bioorganic and Medicinal Chemistry Letters, 2013, vol. 23, # 17, p. 4979 - 4984
ETHYL 2-(4-CHLOROPHENYLAMINO)-4-THIAZOLECARBOXYLATE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from ETHYL 2-(4-CHLOROPHENYLAMINO)-4-THIAZOLECARBOXYLATE manufacturers
- Product
- ETHYL 2-(4-CHLOROPHENYLAMINO)-4-THIAZOLECARBOXYLATE 165682-93-9
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 95%~99%
- Supply Ability
- per week 100kg
- Release date
- 2019-09-05