ChemicalBook > CAS DataBase List > ETHYL 2-(4-CHLOROPHENYLAMINO)-4-THIAZOLECARBOXYLATE

ETHYL 2-(4-CHLOROPHENYLAMINO)-4-THIAZOLECARBOXYLATE

Product Name: ETHYL 2-(4-CHLOROPHENYLAMINO)-4-THIAZOLECARBOXYLATE
CAS No.: 165682-93-9
Chemical Name: ETHYL 2-(4-CHLOROPHENYLAMINO)-4-THIAZOLECARBOXYLATE
Synonyms: O4I2;O412;O4I2, >98%;O4I-2;O4I 2;O4I2 >=98% (HPLC);O4I2, 10 mM in DMSO;ethyl 2-(4-chlorophenylamino)thiazole-4-carboxylate;ETHYL 2-(4-CHLOROPHENYLAMINO)-4-THIAZOLECARBOXYLATE;ethyl 2-(4-chloroanilino)-1,3-thiazole-4-carboxylate;Ethyl 4-((4-chlorophenyl)amino)-3,5-thiazolecarboxylate
CBNumber: CB9689231
Molecular Formula: C12H11ClN2O2S
Formula Weight: 282.75
MOL File: 165682-93-9.mol

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ETHYL 2-(4-CHLOROPHENYLAMINO)-4-THIAZOLECARBOXYLATE Property

Boiling point:: 408.1±51.0 °C(Predicted)
Density: 1.382±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
solubility: DMSO:20.0(Max Conc. mg/mL);70.7(Max Conc. mM)
form: A crystalline solid
pka: 1.48±0.10(Predicted)
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P322Specific measures (see …on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P363Wash contaminated clothing before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1428
Product name: O4I2
Purity: ≥98% (HPLC)
Packaging: 25 mg
Price: $323
Updated: 2025/07/31

TCI Chemical

Product number: O0624
Product name: O4I2
Packaging: 25MG
Price: $270
Updated: 2025/07/31

Cayman Chemical

Product number: 19135
Product name: O4I2
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 19135
Product name: O4I2
Purity: ≥98%
Packaging: 5mg
Price: $86
Updated: 2024/03/01

Cayman Chemical

Product number: 19135
Product name: O4I2
Purity: ≥98%
Packaging: 10mg
Price: $117
Updated: 2024/03/01

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ETHYL 2-(4-CHLOROPHENYLAMINO)-4-THIAZOLECARBOXYLATE Chemical Properties,Usage,Production

Uses

O4I2 is a potent inducer of Oct3/4 expression.

Biological Activity

O4I2 is a potent inducer of the Octamer-binding transcription factor 4 (Oct3/4) in various human cell lines including human fibroblasts. In principle O4I2 could be a useful tool for chemical-mediated induction of pluripotency in somatic cells.

Synthesis

70-23-5

3696-23-9

165682-93-9

GENERAL METHODOLOGY: General procedure for the preparation of ethyl 2-((4-chlorophenyl)amino)thiazole-4-carboxylate: a mixture of ethyl 3-bromopyruvate (2.14 g, 11 mmol) and 1-(4-chlorophenyl)thiourea (0.75 g, 10 mmol) was milled in the presence of Na2CO3 (0.50 g) for 5-6 min. The reaction process was monitored by TLC. After completion of the reaction, water (20 ml) was added to the reaction mixture and subsequently extracted with chloroform (20 ml). The separated organic layer was dried with anhydrous sodium sulfate. Excess solvent was removed by distillation. The crude product was filtered and crystallized from aqueous ethanol to give pure solid product in 83% yield. Similarly, other derivatives can be prepared according to the above method and their structures were confirmed by comparison of melting points with literature values.

storage

Store at -20°C

References

[1] Journal of Medicinal Chemistry, 2015, vol. 58, # 15, p. 5742 - 5750
[2] European Journal of Medicinal Chemistry, 2016, vol. 123, p. 718 - 726
[3] Bioorganic and Medicinal Chemistry Letters, 2013, vol. 23, # 17, p. 4979 - 4984

ETHYL 2-(4-CHLOROPHENYLAMINO)-4-THIAZOLECARBOXYLATE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from ETHYL 2-(4-CHLOROPHENYLAMINO)-4-THIAZOLECARBOXYLATE manufacturers

Career Henan Chemical Co

Product: ETHYL 2-(4-CHLOROPHENYLAMINO)-4-THIAZOLECARBOXYLATE 165682-93-9
Price: US $1.00/KG
Min. Order: 1KG
Purity: 95%~99%
Supply Ability: per week 100kg
Release date: 2019-09-05

165682-93-9, ETHYL 2-(4-CHLOROPHENYLAMINO)-4-THIAZOLECARBOXYLATERelated Search:

ETHYL 2-(4-CHLOROPHENYLAMINO)-4-THIAZOLECARBOXYLATE ETHYL 2-[4-CHLORO-3-(TRIFLUOROMETHYL)ANILINO]-1,3-THIAZOLE-4-CARBOXYLATE 2-(4-Chloro-phenylamino)-thiazole-4-carboxylic acid Ethyl 2-(phenylamino)-4-thiazolecarboxylate

ETHYL 2-(4-CHLOROPHENYLAMINO)-4-THIAZOLECARBOXYLATE

O4I2

ethyl 2-(4-chlorophenylamino)thiazole-4-carboxylate

O412

2-[(4-chlorophenyl)amino]-4-thiazolecarboxylic acid ethyl ester

ethyl 2-(4-chloroanilino)-1,3-thiazole-4-carboxylate

O4I-2;O4I 2

O4I2, >98%

4-Thiazolecarboxylic acid, 2-[(4-chlorophenyl)amino]-, ethyl ester

O4I2 >=98% (HPLC)

O4I2, 10 mM in DMSO

Ethyl 4-((4-chlorophenyl)amino)-3,5-thiazolecarboxylate

165682-93-9

C12H11ClN2O2S

Inhibitors

Stem Cell