(R)-4-BOC-THIOMORPHOLINE-3-CARBOXYLIC ACID

Product Name: (R)-4-BOC-THIOMORPHOLINE-3-CARBOXYLIC ACID
CAS No.: 114525-81-4
Chemical Name: (R)-4-BOC-THIOMORPHOLINE-3-CARBOXYLIC ACID
Synonyms: (R)-BOC-3-CARBOXYTHIOMORPHOLINE;(R)-4-BOC-THIOMORPHOLINE-3-CARBOXYLIC ACID;(R)-N-BOC-THIOMORPHOLINE-3-CARBOXYLIC ACID;R-ThioMorpholine-3,4-dicarboxylic acid 4-tert-butyl ester;(R)-4-(TERT-BUTOXYCARBONYL)-THIOMORPHOLINE-3-CARBOXYLIC ACID;(R)-4-(tert-Butoxycarbonyl)thiomorpholine-3-carboxylic acid - [B91127];3,4-Thiomorpholinedicarboxylic acid, 4-(1,1-dimethylethyl) ester, (3R)-
CBNumber: CB9689574
Molecular Formula: C10H17NO4S
Formula Weight: 247.31
MOL File: 114525-81-4.mol

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(R)-4-BOC-THIOMORPHOLINE-3-CARBOXYLIC ACID Property

Boiling point:: 398.6±42.0 °C(Predicted)
Density: 1.259±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
pka: 3.53±0.20(Predicted)
Appearance: White to off-white Solid

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Safety

HS Code: 29334900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B200893
Product name: (R)-4-Boc-thiomorpholine-3-carboxylicAcid
Packaging: 100mg
Price: $65
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB56439
Product name: (R)-4-Boc-thiomorpholine-3-carboxylic acid
Packaging: 250mg
Price: $77.5
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB56439
Product name: (R)-4-Boc-thiomorpholine-3-carboxylic acid
Packaging: 500mg
Price: $125
Updated: 2021/12/16

AK Scientific

Product number: Z7512
Product name: (R)-4-Boc-thiomorpholine-3-carboxylicacid
Packaging: 250mg
Price: $144
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB56439
Product name: (R)-4-Boc-thiomorpholine-3-carboxylic acid
Packaging: 1g
Price: $302.4
Updated: 2021/12/16

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(R)-4-BOC-THIOMORPHOLINE-3-CARBOXYLIC ACID Chemical Properties,Usage,Production

Synthesis

24424-99-5

65527-54-0

114525-81-4

GENERAL STEPS: To a 1000 mL round bottom flask was added (3R)-thiomorpholine-3-carboxylic acid hydrochloride (10.0 g, 0.054 mol), di-tert-butyl dicarbonate (13.0 g, 0.060 mol), sodium bicarbonate (45.0 g, 0.536 mol), and methanol (500 mL). The mixture was stirred at room temperature for 24 hours. Upon completion of the reaction, methanol was removed by distillation under reduced pressure. The residue was dissolved in water and washed three times with ether. Subsequently, the pH of the aqueous phase was adjusted to 2 with saturated potassium bisulfate solution and extracted with dichloromethane three times. The organic phases were combined, washed 3 times with saturated sodium chloride solution, dried over anhydrous sodium sulfate and concentrated. The crude product was purified by silica gel column chromatography (eluent: petroleum ether/ethyl acetate/acetic acid) to afford 8.63 g of white solid product in 64.6% yield. The structure of the product was confirmed by 1H-NMR (400 MHz, CDCl3) and EI-MS: 1H-NMR δ 5.33 (1H, d, J = 90.4 Hz), 4.39 (1H, br m), 3.30 (2H, br m), 2.95 (1H, m), 2.71 (1H, m), 2.53 (1H, m), 1.53 (9H, s) ; EI-MS m/z: 247.1 [M]+.

References

[1] Patent: EP2805947, 2014, A1. Location in patent: Paragraph 0076-0077
[2] Patent: US5679674, 1997, A

(R)-4-BOC-THIOMORPHOLINE-3-CARBOXYLIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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(R)-4-BOC-THIOMORPHOLINE-3-CARBOXYLIC ACID Suppliers

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114525-81-4, (R)-4-BOC-THIOMORPHOLINE-3-CARBOXYLIC ACIDRelated Search:

4-N-BOC-THIOMORPHOLINE-3-CARBOXYLIC ACID (S)-4-BOC-THIOMORPHOLINE-3-CARBOXYLIC ACID N-BOC-THIOMORPHOLINE-3-CARBOXYLIC ACID ETHYL ESTER (R)-4-(TERT-BUTOXYCARBONYL)-2,2-DIMETHYLTHIOMORPHOLINE-3-CARBOXYLIC ACID (R)-4-BOC-THIOMORPHOLINE-3-CARBOXYLIC ACID (3R)-THIOMORPHOLINECARBOXYLIC ACID Thiomorpholine-3-carboxylic acid 4-BOC-THIOMORPHOLINE-3-CARBOXYLIC ACID,(R)-4-BOC-THIOMORPHOLINE-3-CARBOXYLIC ACID

3,4-Thiomorpholinedicarboxylic acid, 4-(1,1-dimethylethyl) ester, (3R)-

(R)-4-BOC-THIOMORPHOLINE-3-CARBOXYLIC ACID

(R)-4-(TERT-BUTOXYCARBONYL)-THIOMORPHOLINE-3-CARBOXYLIC ACID

(R)-BOC-3-CARBOXYTHIOMORPHOLINE

(R)-N-BOC-THIOMORPHOLINE-3-CARBOXYLIC ACID

R-ThioMorpholine-3,4-dicarboxylic acid 4-tert-butyl ester

(R)-4-(tert-Butoxycarbonyl)thiomorpholine-3-carboxylic acid - [B91127]

114525-81-4