(R)-4-BOC-THIOMORPHOLINE-3-CARBOXYLIC ACID

Product Name: (R)-4-BOC-THIOMORPHOLINE-3-CARBOXYLIC ACID
CAS No.: 128453-98-5
Chemical Name: (R)-4-BOC-THIOMORPHOLINE-3-CARBOXYLIC ACID
Synonyms: BUTTPARK 147\06-74;N-Boc-3-thioMorpholinecarboxylic Acid;4-BOC-THIOMORPHOLINE-3-CARBOXYLIC ACID;4-(tert-Butyl) 3,4-thiomorpholinedicarboxylate;THIOMORPHOLINE-3-CARBOXYLIC ACID, N-BOC PROTECTED;4-(1,1-Dimethylethyl) 3,4-thiomorpholinedicarboxylate;4-(tert-Butoxycarbonyl)thiomorpholine-3-carboxylicaci;4-(TERT-BUTOXYCARBONYL)THIOMORPHOLINE-3-CARBOXYLIC ACID;THIOMORPHOLINE-3,4-DICARBOXYLIC ACID 4-TERT-BUTYL ESTER;(R)-4-(TERT-BUTOXYCARBONYL)-THIOMORPHOLINE-3-CARBOXYLIC ACID
CBNumber: CB2689575
Molecular Formula: C10H17NO4S
Formula Weight: 247.31
MOL File: 128453-98-5.mol

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(R)-4-BOC-THIOMORPHOLINE-3-CARBOXYLIC ACID Property

Melting point:: 145-146
Boiling point:: 398.6±42.0 °C(Predicted)
Density: 1.259±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 3.53±0.20(Predicted)
Appearance: Off-white to brown Solid
optical activity: -0.74°(C=1.0 g/100ml MEOH)
InChI: InChI=1S/C10H17NO4S/c1-10(2,3)15-9(14)11-4-5-16-6-7(11)8(12)13/h7H,4-6H2,1-3H3,(H,12,13)
InChIKey: CTDIKDIZNAGMFK-UHFFFAOYSA-N
SMILES: N1(C(OC(C)(C)C)=O)CCSCC1C(O)=O

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 22-36/37/38
Safety Statements: 26
Hazard Note: Irritant
HS Code: 2934999090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC

Product number: B812463
Product name: 4-(tert-butoxycarbonyl)thiomorpholine-3-carboxylicacid
Packaging: 50mg
Price: $65
Updated: 2021/12/16

TRC

Product number: B812463
Product name: 4-(tert-butoxycarbonyl)thiomorpholine-3-carboxylicacid
Packaging: 10mg
Price: $45
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB144343
Product name: 4-(tert-Butoxycarbonyl)thiomorpholine-3-carboxylic acid
Packaging: 1g
Price: $126
Updated: 2021/12/16

SynQuest Laboratories

Product number: 8H70-1-T1
Product name: Thiomorpholine-3-carboxylic acid, N-Boc protected
Packaging: 250mg
Price: $66
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB144343
Product name: 4-(tert-Butoxycarbonyl)thiomorpholine-3-carboxylic acid
Packaging: 500mg
Price: $70
Updated: 2021/12/16

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(R)-4-BOC-THIOMORPHOLINE-3-CARBOXYLIC ACID Chemical Properties,Usage,Production

Synthesis

123-91-1

24424-99-5

20960-92-3

128453-98-5

The general procedure for the synthesis of N-Boc-3-thiomorpholinecarboxylic acid from 1,4-dioxane, di-tert-butyl dicarbonate and 3-thiomorpholinecarboxylic acid is as follows: (a) Synthesis of 4-(tert-butoxycarbonyl)thiomorpholine-3-carboxylic acid: triethylamine (23.6 mL) was slowly added to a solution of DL-thiomorpholine-3-carboxylic acid (5 g) dissolved in 40 mL of a solvent mixture of 1,4-dioxane and water (1:1, v/v) at 0 °C. Subsequently, di-tert-butyl dicarbonate (8.16 g) was added and the reaction mixture was stirred at 0 °C for 30 min and then continued for 3 h at room temperature. After completion of the reaction, the solvent was removed by evaporation under reduced pressure and the residue was dissolved in 100 mL of ethyl acetate. The pH of the reaction solution was adjusted to 4 with saturated citric acid solution and then extracted with ethyl acetate. The organic layers were combined, dried over anhydrous sodium sulfate and concentrated under reduced pressure. The residue was recrystallized by hexane/ethyl acetate mixed solvent to give 4-(tert-butoxycarbonyl)thiomorpholine-3-carboxylic acid (6.0 g, 71% yield).

References

[1] Patent: US5021413, 1991, A

(R)-4-BOC-THIOMORPHOLINE-3-CARBOXYLIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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(R)-4-BOC-THIOMORPHOLINE-3-CARBOXYLIC ACID Suppliers

Belgium 1 China 47 France 1 Germany 2 India 1 United Kingdom 7 United States 17 Global 76

Shanghai Anmike Chemical Co. Ltd.

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ShangHai AmK Pharmaceutical Technology Co., Ltd.

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Shanghai Tombiopharma Chemical Co. Ltd.

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View Lastest Price from (R)-4-BOC-THIOMORPHOLINE-3-CARBOXYLIC ACID manufacturers

Career Henan Chemical Co

Product: (R)-4-BOC-THIOMORPHOLINE-3-CARBOXYLIC ACID 128453-98-5
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200kg
Release date: 2020-01-09

128453-98-5, (R)-4-BOC-THIOMORPHOLINE-3-CARBOXYLIC ACIDRelated Search:

Thiomorpholine Thiomorpholine-3-carboxylic acid 4-N-BOC-THIOMORPHOLINE-3-CARBOXYLIC ACID (S)-4-BOC-THIOMORPHOLINE-3-CARBOXYLIC ACID N-BOC-THIOMORPHOLINE-3-CARBOXYLIC ACID ETHYL ESTER N-BOC-THIOMORPHOLINE-3-CARBOXYLIC ACID ETHYL ESTER (R)-4-BOC-THIOMORPHOLINE-3-CARBOXYLIC ACID (R)-4-(TERT-BUTOXYCARBONYL)-2,2-DIMETHYLTHIOMORPHOLINE-3-CARBOXYLIC ACID (R)-4-BOC-THIOMORPHOLINE-3-CARBOXYLIC ACID

4-BOC-THIOMORPHOLINE-3-CARBOXYLIC ACID

4-(TERT-BUTOXYCARBONYL)THIOMORPHOLINE-3-CARBOXYLIC ACID

THIOMORPHOLINE-3-CARBOXYLIC ACID, N-BOC PROTECTED

(+/-)-THIOMORPHOLINE-3,4-DICARBOXYLIC ACID 4-TERT-BUTYL ESTER

THIOMORPHOLINE-3,4-DICARBOXYLIC ACID 4-TERT-BUTYL ESTER

(R)-4-(TERT-BUTOXYCARBONYL)-THIOMORPHOLINE-3-CARBOXYLIC ACID

BUTTPARK 147\06-74

N-Boc-3-thioMorpholinecarboxylic Acid

3,4-Thiomorpholinedicarboxylic acid, 4-(1,1-dimethylethyl) ester

4-(tert-Butoxycarbonyl)thiomorpholine-3-carboxylic acid, 4-(tert-Butoxycarbonyl)-3-carboxythiomorpholine

4-(1,1-Dimethylethyl) 3,4-thiomorpholinedicarboxylate

4-(tert-Butoxycarbonyl)thiomorpholine-3-carboxylicaci

4-(tert-Butyl) 3,4-thiomorpholinedicarboxylate

128453-98-5