ChemicalBook > CAS DataBase List > (R)-4-BOC-THIOMORPHOLINE-3-CARBOXYLIC ACID

(R)-4-BOC-THIOMORPHOLINE-3-CARBOXYLIC ACID

Product Name
(R)-4-BOC-THIOMORPHOLINE-3-CARBOXYLIC ACID
CAS No.
128453-98-5
Chemical Name
(R)-4-BOC-THIOMORPHOLINE-3-CARBOXYLIC ACID
Synonyms
BUTTPARK 147\06-74;N-Boc-3-thioMorpholinecarboxylic Acid;4-BOC-THIOMORPHOLINE-3-CARBOXYLIC ACID;4-(tert-Butyl) 3,4-thiomorpholinedicarboxylate;THIOMORPHOLINE-3-CARBOXYLIC ACID, N-BOC PROTECTED;4-(1,1-Dimethylethyl) 3,4-thiomorpholinedicarboxylate;4-(tert-Butoxycarbonyl)thiomorpholine-3-carboxylicaci;4-(TERT-BUTOXYCARBONYL)THIOMORPHOLINE-3-CARBOXYLIC ACID;THIOMORPHOLINE-3,4-DICARBOXYLIC ACID 4-TERT-BUTYL ESTER;(R)-4-(TERT-BUTOXYCARBONYL)-THIOMORPHOLINE-3-CARBOXYLIC ACID
CBNumber
CB2689575
Molecular Formula
C10H17NO4S
Formula Weight
247.31
MOL File
128453-98-5.mol
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(R)-4-BOC-THIOMORPHOLINE-3-CARBOXYLIC ACID Property

Melting point:
145-146
Boiling point:
398.6±42.0 °C(Predicted)
Density 
1.259±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
pka
3.53±0.20(Predicted)
Appearance
Off-white to brown Solid
optical activity
-0.74°(C=1.0 g/100ml MEOH)
InChI
InChI=1S/C10H17NO4S/c1-10(2,3)15-9(14)11-4-5-16-6-7(11)8(12)13/h7H,4-6H2,1-3H3,(H,12,13)
InChIKey
CTDIKDIZNAGMFK-UHFFFAOYSA-N
SMILES
N1(C(OC(C)(C)C)=O)CCSCC1C(O)=O
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
22-36/37/38
Safety Statements 
26
Hazard Note 
Irritant
HS Code 
2934999090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC
Product number
B812463
Product name
4-(tert-butoxycarbonyl)thiomorpholine-3-carboxylicacid
Packaging
10mg
Price
$45
Updated
2021/12/16
TRC
Product number
B812463
Product name
4-(tert-butoxycarbonyl)thiomorpholine-3-carboxylicacid
Packaging
50mg
Price
$65
Updated
2021/12/16
SynQuest Laboratories
Product number
8H70-1-T1
Product name
Thiomorpholine-3-carboxylic acid, N-Boc protected
Packaging
250mg
Price
$66
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB144343
Product name
4-(tert-Butoxycarbonyl)thiomorpholine-3-carboxylic acid
Packaging
500mg
Price
$70
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB144343
Product name
4-(tert-Butoxycarbonyl)thiomorpholine-3-carboxylic acid
Packaging
1g
Price
$126
Updated
2021/12/16
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(R)-4-BOC-THIOMORPHOLINE-3-CARBOXYLIC ACID Chemical Properties,Usage,Production

Synthesis

123-91-1

24424-99-5

20960-92-3

128453-98-5

The general procedure for the synthesis of N-Boc-3-thiomorpholinecarboxylic acid from 1,4-dioxane, di-tert-butyl dicarbonate and 3-thiomorpholinecarboxylic acid is as follows: (a) Synthesis of 4-(tert-butoxycarbonyl)thiomorpholine-3-carboxylic acid: triethylamine (23.6 mL) was slowly added to a solution of DL-thiomorpholine-3-carboxylic acid (5 g) dissolved in 40 mL of a solvent mixture of 1,4-dioxane and water (1:1, v/v) at 0 °C. Subsequently, di-tert-butyl dicarbonate (8.16 g) was added and the reaction mixture was stirred at 0 °C for 30 min and then continued for 3 h at room temperature. After completion of the reaction, the solvent was removed by evaporation under reduced pressure and the residue was dissolved in 100 mL of ethyl acetate. The pH of the reaction solution was adjusted to 4 with saturated citric acid solution and then extracted with ethyl acetate. The organic layers were combined, dried over anhydrous sodium sulfate and concentrated under reduced pressure. The residue was recrystallized by hexane/ethyl acetate mixed solvent to give 4-(tert-butoxycarbonyl)thiomorpholine-3-carboxylic acid (6.0 g, 71% yield).

References

[1] Patent: US5021413, 1991, A

(R)-4-BOC-THIOMORPHOLINE-3-CARBOXYLIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from (R)-4-BOC-THIOMORPHOLINE-3-CARBOXYLIC ACID manufacturers

Career Henan Chemical Co
Product
(R)-4-BOC-THIOMORPHOLINE-3-CARBOXYLIC ACID 128453-98-5
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
200kg
Release date
2020-01-09

128453-98-5, (R)-4-BOC-THIOMORPHOLINE-3-CARBOXYLIC ACIDRelated Search:

Thiomorpholine Thiomorpholine-3-carboxylic acid 4-N-BOC-THIOMORPHOLINE-3-CARBOXYLIC ACID (S)-4-BOC-THIOMORPHOLINE-3-CARBOXYLIC ACID N-BOC-THIOMORPHOLINE-3-CARBOXYLIC ACID ETHYL ESTER N-BOC-THIOMORPHOLINE-3-CARBOXYLIC ACID ETHYL ESTER (R)-4-BOC-THIOMORPHOLINE-3-CARBOXYLIC ACID (R)-4-(TERT-BUTOXYCARBONYL)-2,2-DIMETHYLTHIOMORPHOLINE-3-CARBOXYLIC ACID (R)-4-BOC-THIOMORPHOLINE-3-CARBOXYLIC ACID

  • 4-BOC-THIOMORPHOLINE-3-CARBOXYLIC ACID
  • 4-(TERT-BUTOXYCARBONYL)THIOMORPHOLINE-3-CARBOXYLIC ACID
  • THIOMORPHOLINE-3-CARBOXYLIC ACID, N-BOC PROTECTED
  • (+/-)-THIOMORPHOLINE-3,4-DICARBOXYLIC ACID 4-TERT-BUTYL ESTER
  • THIOMORPHOLINE-3,4-DICARBOXYLIC ACID 4-TERT-BUTYL ESTER
  • (R)-4-(TERT-BUTOXYCARBONYL)-THIOMORPHOLINE-3-CARBOXYLIC ACID
  • BUTTPARK 147\06-74
  • N-Boc-3-thioMorpholinecarboxylic Acid
  • 3,4-Thiomorpholinedicarboxylic acid, 4-(1,1-dimethylethyl) ester
  • 4-(tert-Butoxycarbonyl)thiomorpholine-3-carboxylic acid, 4-(tert-Butoxycarbonyl)-3-carboxythiomorpholine
  • 4-(1,1-Dimethylethyl) 3,4-thiomorpholinedicarboxylate
  • 4-(tert-Butoxycarbonyl)thiomorpholine-3-carboxylicaci
  • 4-(tert-Butyl) 3,4-thiomorpholinedicarboxylate
  • 128453-98-5