3,4,5-TRICHLOROANILINE

Product Name: 3,4,5-TRICHLOROANILINE
CAS No.: 634-91-3
Chemical Name: 3,4,5-TRICHLOROANILINE
Synonyms: NSC 115260;3,4,5-TRICHLOROANILINE;Aniline, 3,4,5-trichloro-;3,4,5-Trichloroaniline 97%;3,4,5-Trichlorobenzenamine;3,4,5-Trichloroaniline,97%;3,4,5-Trichloroaniline ,98%;Phloroglucinol Impurity 133;BenzenaMine, 3,4,5-trichloro-;3,4,5-Trichloroaniline, 97% 1GR
CBNumber: CB9699269
Molecular Formula: C6H4Cl3N
Formula Weight: 196.46
MOL File: 634-91-3.mol

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3,4,5-TRICHLOROANILINE Property

Melting point:: 97-99 °C (lit.)
Boiling point:: 321.87°C (rough estimate)
Density: 1.540
refractive index: 1.5596 (estimate)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
form: powder to crystal
pka: 1.85±0.10(Predicted)
color: White to Light yellow
Water Solubility: Insoluble in water.
BRN: 638880
InChI: InChI=1S/C6H4Cl3N/c7-4-1-3(10)2-5(8)6(4)9/h1-2H,10H2
InChIKey: XOGYQVITULCUGU-UHFFFAOYSA-N
SMILES: C1(N)=CC(Cl)=C(Cl)C(Cl)=C1
CAS DataBase Reference: 634-91-3(CAS DataBase Reference)

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Safety

Hazard Codes: T,N
Risk Statements: 23/24/25-33-50/53
Safety Statements: 28-36/37-45-60-61
RIDADR: UN 2811 6.1/PG 2
WGK Germany: 3
HazardClass: 6.1
PackingGroup: II
HS Code: 29214200

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H373May cause damage to organs through prolonged or repeated exposure

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P314Get medical advice/attention if you feel unwell.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 187119
Product name: 3,4,5-Trichloroaniline
Purity: 97%
Packaging: 5g
Price: $391
Updated: 2023/01/07

Sigma-Aldrich

Product number: 187119
Product name: 3,4,5-Trichloroaniline
Purity: 97%
Packaging: 25g
Price: $1340
Updated: 2022/05/15

TCI Chemical

Product number: T3008
Product name: 3,4,5-Trichloroaniline
Purity: >98.0%(GC)(T)
Packaging: 1g
Price: $234
Updated: 2025/07/31

TRC

Product number: T774020
Product name: 3,4,5-Trichloroaniline
Packaging: 2.5g
Price: $155
Updated: 2021/12/16

TRC

Product number: T774020
Product name: 3,4,5-Trichloroaniline
Packaging: 5g
Price: $210
Updated: 2021/12/16

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3,4,5-TRICHLOROANILINE Chemical Properties,Usage,Production

Chemical Properties

BEIGE CRYSTALLINE POWDER

Uses

3,4,5-Trichloroaniline is a useful building block available (see catalogue entries T774090, T774323, and T774025 for its isomers). 3,4,5-Trichloroaniline has been used in the preparation of novel 3,4-dihydroisoquinoline compounds as potential antidepressant agents.

General Description

3,4,5-Trichloroaniline forms tri- and tetrachloroaniline-Pt(II) complexes having good antileukemic activity.

Synthesis

20098-48-0

634-91-3

The general procedure for the synthesis of 3,4,5-trichloroaniline from 1,2,3-trichloro-5-nitrobenzene was as follows: to a reaction glass vial fitted with a magnetic stir bar and a septum cap pierced with a syringe needle was added the Co3O4/NGrC catalyst (2 mol%, 3 wt% Co-phenanthroline on carbon, 20 mg), followed by nitro aromatics (0.5 mmol), internal standard (hexadecane, 100 μL), THF (2 mL), and H2O (200 μL). The reaction vials were placed in a 300 mL autoclave and the autoclave was flushed twice with nitrogen and then pressurized at 30 bar with CO The autoclave pressure was adjusted to 60 bar by supplementing with nitrogen and placed in an aluminum block preheated to 125 °C. After 24 hours of reaction, the autoclave was transferred to a water bath and cooled to room temperature. After venting the remaining gas, the reaction mixture was removed, diluted with EtOAc and analyzed by GC. To determine the yield of the isolated product, the general procedure was carried out at two-fold scale-up and without the addition of an internal standard. Upon completion of the reaction, the catalyst was removed by filtration, the filtrate was concentrated and purified by silica gel column chromatography (n-heptane-EtOAc mixed solvent) to afford the target product 3,4,5-trichloroaniline.

References

[1] Advanced Synthesis and Catalysis, 2012, vol. 354, # 2-3, p. 321 - 327
[2] Anales de Quimica, 1996, vol. 92, # 2, p. 95 - 100
[3] Journal of Organic Chemistry, 1947, vol. 12, p. 275,278, 280
[4] Zhurnal Prikladnoi Khimii (Sankt-Peterburg, Russian Federation), 1948, vol. 21, p. 1152,1158
[5] Chem. Zentralbl., 1949, vol. 120, p. 6193

3,4,5-TRICHLOROANILINE Preparation Products And Raw materials

Raw materials

Preparation Products

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3,4,5-TRICHLOROANILINE Suppliers

Belgium 1 China 104 France 1 Germany 3 India 7 Japan 2 Switzerland 1 United Kingdom 4 United States 16 Global 139

Jia Xing Isenchem Co.,Ltd

Tel: 0573-85285100 18627885956
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Grice Rand (Tianjin) Pharmaceutical Co., Ltd.

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J & K SCIENTIFIC LTD.

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Energy Chemical

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Shandong Xiya Chemical Co., Ltd

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Syntechem Co.,Ltd

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Maya High Purity Chemicals

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View Lastest Price from 3,4,5-TRICHLOROANILINE manufacturers

Honest Joy Holdings Limited

Product: 3,4,5-Trichloroaniline 634-91-3
Price: US $0.00/KG
Min. Order: 1KG
Purity: 97.3%
Supply Ability: 100 tons
Release date: 2022-01-14

Career Henan Chemical Co

Product: 3,4,5-TRICHLOROANILINE 634-91-3
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1kg; 10kg; 100kg
Release date: 2019-08-30

634-91-3, 3,4,5-TRICHLOROANILINERelated Search:

2,3,4,5-Tetrachloronitrobenzene 1,2,3,4-TETRACHLORO-5,6-DINITROBENZENE 2,3,4,5-TETRACHLOROPHENYL ISOTHIOCYANATE Pentachloroaniline 3,4,5-TRICHLOROANILINE 3,4,5-Trichloronitrobenzene Quintozine 2,3,4,5-TETRACHLOROANILINE 2,4,5-Trichloroaniline hydrochloride 2,4,5-TRICHLOROANILINE,2,4,5-Trichloroaniline,97%,2,4,5-Trichloroaniline, tech., 97%,2,4,5-TRICHLOROANILINE PESTANAL 2,4,6-Trichloroaniline Trichloroaniline,2,3,4-TRICHLOROANILINE OEKANAL, 250 MG trichlorobenzene N-(2-Aminoethyl)-N-(pentachlorophenyl)amine N-CYCLOHEXYLMETHYL-2,4,6-TRICHLOROANILINE 2,3,5-trichloroaniline N-(CYCLOHEXYMETHYL)-2,4,6-TRICHLOROANILINE N-METHYLTETRACHLORODIHYDRO INDOLE

3,4,5-Trichlorobenzenamine

Aniline, 3,4,5-trichloro-

3,4,5-TRICHLOROANILINE

3,4,5-TRICHLOROANILINE PESTANAL, 250 MG

3,4,5-Trichloroaniline ,98%

3,4,5-Trichloroaniline,97%

3,4,5-Trichloroaniline, 97% 1GR

NSC 115260

BenzenaMine, 3,4,5-trichloro-

3,4,5-Trichloroaniline 97%

3,4,5-TRICHLOROANILINE ISO 9001：2015 REACH

Phloroglucinol Impurity 133

C17700300 3,4,5-Trichloroaniline

634-91-3

C6H4CI3N

C6H4Cl3N

AMINE

C2 to C6

Building Blocks

Amines

Organic Building Blocks

Nitrogen Compounds

Amines

C2 to C6

Nitrogen Compounds