Genotoxicity
ChemicalBook > CAS DataBase List > 2,4,6-Trichloroaniline

2,4,6-Trichloroaniline

Genotoxicity
Product Name
2,4,6-Trichloroaniline
CAS No.
634-93-5
Chemical Name
2,4,6-Trichloroaniline
Synonyms
2,4,6-tca;2.4.6-Trichlor;2,4,6-Trichlorophenylamine;2,4,6-trichlorobenzenamine;s-Trichloroaniline;sym-Trichloroaniline;2,4,6-Trichloranilin;2,4,6-Trichloroanili;Clonidine Impurity 7;2,4,6-trichloraniline
CBNumber
CB2854049
Molecular Formula
C6H4Cl3N
Formula Weight
196.46
MOL File
634-93-5.mol
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2,4,6-Trichloroaniline Property

Melting point:
73-75 °C (lit.)
Boiling point:
262 °C (lit.)
Density 
1.6807 (rough estimate)
vapor pressure 
0-0.631Pa at 25℃
refractive index 
1.6300 (estimate)
Flash point:
262°C
storage temp. 
Storage temperature: no restrictions.
solubility 
0.039g/l slightly soluble
pka
0.07±0.10(Predicted)
color 
Needles or liquid from pet ether
Water Solubility 
<0.1 g/100 mL at 21.5 ºC
BRN 
879568
Stability:
Stable, but may be light or air sensitive. Incompatible with acids, acid chlorides, acid anhydrides, chloroformates, strong oxidizing agents.
InChIKey
NATVSFWWYVJTAZ-UHFFFAOYSA-N
LogP
3.648-3.69 at 25℃
CAS DataBase Reference
634-93-5(CAS DataBase Reference)
NIST Chemistry Reference
Benzenamine, 2,4,6-trichloro-(634-93-5)
EPA Substance Registry System
2,4,6-Trichloroaniline (634-93-5)
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Safety

Hazard Codes 
T,N
Risk Statements 
23/24/25-33-50/53
Safety Statements 
28-36/37-45-60-61-28A
RIDADR 
UN 2811 6.1/PG 2
WGK Germany 
3
RTECS 
BZ0250000
Hazard Note 
Toxic
TSCA 
Yes
HazardClass 
6.1
PackingGroup 
II
HS Code 
29214200
Hazardous Substances Data
634-93-5(Hazardous Substances Data)
Toxicity
LD50 orl-rat: 2400 mg/kg GISAAA 55(6),86,90
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H311Toxic in contact with skin

H331Toxic if inhaled

H373May cause damage to organs through prolonged or repeated exposure

H400Very toxic to aquatic life

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P311Call a POISON CENTER or doctor/physician.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical
Product number
T0375
Product name
2,4,6-Trichloroaniline
Purity
>98.0%(GC)
Packaging
25g
Price
$30
Updated
2024/03/01
TCI Chemical
Product number
T0375
Product name
2,4,6-Trichloroaniline
Purity
>98.0%(GC)
Packaging
500g
Price
$268
Updated
2024/03/01
Alfa Aesar
Product number
A19044
Product name
2,4,6-Trichloroaniline, 98+%
Packaging
25g
Price
$32.65
Updated
2024/03/01
Alfa Aesar
Product number
A19044
Product name
2,4,6-Trichloroaniline, 98+%
Packaging
100g
Price
$74.65
Updated
2024/03/01
Alfa Aesar
Product number
A19044
Product name
2,4,6-Trichloroaniline, 98+%
Packaging
500g
Price
$284
Updated
2021/12/16
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2,4,6-Trichloroaniline Chemical Properties,Usage,Production

Genotoxicity

Limited information is available regarding the potential genotoxicity of 2,4,6-trichloroaniline. 2,4,6-Trichloroaniline did not induce mutations in Salmonella typhimurium strains TA98, TA100, or TA1537 in the presence or absence of metabolic activation in plate-incorporation assays; microsomal-suspension assays using the same strains and metabolic-activation preparations were also negative. However, using the preincubation method, 2,4,6-trichloroaniline tested positive for mutagenicity in Salmonella and Escherichia coli (strains not specified). 2,4,6-Trichloroaniline tested negative in the Salmonella umu (SOS response) assay and failed to induce DNA repair in rat hepatocytes. In vivo, 2,4,6-trichloroaniline was mutagenic in the wing spot test in Drosophila. Rats treated orally with 2,4,6-trichloroaniline at 40 mg/kg-day (but not 0.4 or 4 mg/kg-day) for 6 months showed a small but statistically significant increase (p < 0.05) in the number of bone marrow cells containing chromosomal aberrations when compared with controls (1.6% vs. 0.4%, respectively); however, this study did not provide any study design details.

Description

Trichloroaniline is particularly important as a chemical intermediate in manufacturing many benzene derivatives and other organic compounds. For instance, 2,4,6-trichloroaniline is an essential precursor of 1,3,5-trichlorobenzene. The latter has been extensively studied and developed for insecticides and fungicides. It, in turn, is a precursor of trichlorodinitrobenzene, which is especially important in combatting crop diseases and is an intermediate for dyestuffs. In military applications, 2,4,6-trichloroaniline is utilized for the preparation of insensitive energetic material that is employed in several Navy weapons systems. The synthesis of 2,4,6-trichloroaniline has almost invariably been accomplished by chlorinating aniline with chlorine or sulfuryl chloride.

Chemical Properties

fine purple fibres

Uses

2,4,6-trichloroaniline is important as an intermediate in the manufacture of benzene derivatives, including 1,3,5-trichlorobenzene and is useful in the formation of fungicides, mono-azo dyestuffs, and the preparation of hexachlorodiphenyl urea.
Tetrachloronitrobenzene was prepared from 2:4:6-trichloroaniline,which was converted by a Sandmeyer reaction into 1:2:3:5- tetrachlorobenzene.

Preparation

2,4,6-Trichloroaniline can be prepared by reaction of dry aniline with chlorine gas while in a anhydrous solution of carbon tetrachloride. 2,4,6-Trichloroaniline precipitates from solution as a white solid. If water is introduced to the solution the white material will polymerize to form aniline black.
Process for the preparation of 2,4,6-trichloroaniline

General Description

Long needles or fine, light purple fibers.

Air & Water Reactions

2,4,6-Trichloroaniline may be sensitive to exposure to light and air. Insoluble in water.

Reactivity Profile

2,4,6-Trichloroaniline is incompatible with acids, acid chlorides, acid anhydrides, chloroformates, and strong oxidizing agents. .

Fire Hazard

Flash point data for 2,4,6-Trichloroaniline are not available. 2,4,6-Trichloroaniline is probably combustible.

Safety Profile

Moderately toxic by ingestion.Irritant. Questionable carcinogen with experimentalcarcinogenic data. Mutation data reported. When heatedto decomposition it emits very toxic fumes of Clí andNOx.

Purification Methods

Crystallise the aniline from ligroin. The benzoyl derivative has m 174o (from EtOH). [Beilstein 12 H 627, 12 IV 1281.]

2,4,6-Trichloroaniline Preparation Products And Raw materials

Raw materials

Preparation Products

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2,4,6-Trichloroaniline Suppliers

Shaanxi Jiandu Pharmaceutical Chemical Co. Ltd.
Tel
029-88380327 17691182729
Fax
029-88380327
Email
1018@dideu.com
Country
China
ProdList
1992
Advantage
58
Changzhou shuicao chemical Nes material Industry?Co.,Ltd.
Tel
13861152845
Email
987349505@qq.com
Country
China
ProdList
113
Advantage
58
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
021-61259108 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15839
Advantage
69
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
Advantage
84
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44689
Advantage
61
Capot Chemical Co., Ltd
Tel
+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
Email
sales@capotchem.com
Country
China
ProdList
18207
Advantage
66
Beijing Ouhe Technology Co., Ltd
Tel
010-82967028 13552068683
Fax
+86-10-82967029
Email
2355560935@qq.com
Country
China
ProdList
12438
Advantage
60
JinYan Chemicals(ShangHai) Co.,Ltd.
Tel
13817811078
Fax
86-021-50426522,50426273
Email
sales@jingyan-chemical.com
Country
China
ProdList
9976
Advantage
60
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View Lastest Price from 2,4,6-Trichloroaniline manufacturers

Hebei Jingbo New Material Technology Co., Ltd
Product
2,4,6-Trichloroaniline 634-93-5
Price
US $8.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20000
Release date
2024-01-02
Hebei Chuanghai Biotechnology Co,.LTD
Product
2,4,6-Trichloroaniline 634-93-5
Price
US $10.70/KG
Min. Order
10KG
Purity
99%
Supply Ability
10000kg
Release date
2024-08-20
Hebei Weibang Biotechnology Co., Ltd
Product
2,4,6-Trichloroaniline 634-93-5
Price
US $50.00-20.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20 MT
Release date
2022-04-13

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