3-Chloroaniline
- Product Name
- 3-Chloroaniline
- CAS No.
- 108-42-9
- Chemical Name
- 3-Chloroaniline
- Synonyms
- M-CHLOROANILINE;3-CHLOROBENZENAMINE;ORANGE GC BASE;1,3-aminochlorobenzene;oroaniL;CI 37005;3-Chloranilin;3-Cloroaniline;m-Chloraniline;3-Chloraniline
- CBNumber
- CB9697982
- Molecular Formula
- C6H6ClN
- Formula Weight
- 127.57
- MOL File
- 108-42-9.mol
3-Chloroaniline Property
- Melting point:
- −11-−9 °C(lit.)
- Boiling point:
- 95-96 °C11 mm Hg(lit.)
- Density
- 1.206 g/mL at 25 °C(lit.)
- vapor pressure
- 1 mm Hg ( 63.5 °C)
- refractive index
- n20/D 1.594(lit.)
- Flash point:
- 255 °F
- storage temp.
- Store below +30°C.
- solubility
- 6.2g/l
- form
- Liquid
- pka
- 3.46(at 25℃)
- color
- Clear pale yellow to brown
- PH
- 7.3 (H2O)(saturated aqueous solution)
- Odor
- Characteristic odour
- Water Solubility
- 6.8 g/L (20 ºC)
- Decomposition
- 190°C
- Merck
- 14,2118
- BRN
- 605969
- Dielectric constant
- 13.4（19℃）
- Stability:
- Material darkens in storage with no loss in purity, Material Darkens In Storage
- LogP
- 0.77-2.03 at 25-30℃
- CAS DataBase Reference
- 108-42-9(CAS DataBase Reference)
- NIST Chemistry Reference
- m-Chloroaniline(108-42-9)
- EPA Substance Registry System
- m-Chloroaniline (108-42-9)
Safety
- Hazard Codes
- T,N
- Risk Statements
- 23/24/25-33-50/53
- Safety Statements
- 28-36/37-45-60-61-28A
- RIDADR
- UN 2019 6.1/PG 2
- WGK Germany
- 2
- RTECS
- BX0350000
- F
- 8-10-23
- Autoignition Temperature
- 705 °C
- Hazard Note
- Toxic
- TSCA
- Yes
- HazardClass
- 6.1
- PackingGroup
- II
- HS Code
- 29214210
- Hazardous Substances Data
- 108-42-9(Hazardous Substances Data)
- Toxicity
- LD50 orally in Rabbit: 256 mg/kg LD50 dermal Rat 250 mg/kg
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H317May cause an allergic skin reaction
H319Causes serious eye irritation
H330Fatal if inhaled
H373May cause damage to organs through prolonged or repeated exposure
H410Very toxic to aquatic life with long lasting effects
- Precautionary statements
-
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P314Get medical advice/attention if you feel unwell.
N-Bromosuccinimide Price
- Product number
- C22407
- Product name
- 3-Chloroaniline
- Purity
- 99%
- Packaging
- 5g
- Price
- $40.2
- Updated
- 2024/03/01
- Product number
- C22407
- Product name
- 3-Chloroaniline
- Purity
- 99%
- Packaging
- 100g
- Price
- $55
- Updated
- 2024/03/01
- Product number
- C0110
- Product name
- 3-Chloroaniline
- Purity
- >99.0%(GC)
- Packaging
- 25mL
- Price
- $18
- Updated
- 2024/03/01
- Product number
- C0110
- Product name
- 3-Chloroaniline
- Purity
- >99.0%(GC)
- Packaging
- 500mL
- Price
- $93
- Updated
- 2024/03/01
- Product number
- A12019
- Product name
- 3-Chloroaniline, 99%
- Packaging
- 100g
- Price
- $36.1
- Updated
- 2024/03/01
3-Chloroaniline Chemical Properties,Usage,Production
Description
m-Chloroaniline is used as an intermediate for pesticides, pharmaceuticals, and dyes. It is produced by lowpressure hydrogenation of 3-chloronitrobenzene in the liquid phase with noble metal and/or noble metal sulfide catalysts. The addition of metal oxides to the reaction helps avoid dehalogenation. The yield is approximately 98 %.
Chemical Properties
3-Chloroaniline is a clear pale yellow to brown liquid, which becomes darker during storage, insoluble in water, but soluble in ethanol, ether and acid solution.
Application
3-Chloroaniline is the intermediate of the herbicide chloraniline, and the intermediate of the pharmaceutical diuretic antihypertensive drug hydrochlorothiazide, and can be used to produce azo dyes.
3-Chloroaniline was the only aniline compound to increase plasmaALT/GPT activity at 48 h. It is employed in the bioaugmentation of activated sludge.
Uses
3-Chlorobenzenamine is used in the synthesis of pyrimidoazepine analogs as serotonin 5-HT2A and 5-HT2C receptor ligands for the treatment of obesity. Also used in the synthesis of novel COX-2 inhibito rs.
Preparation
3-Chloroaniline is obtained by reducing 3-Nitrochlorobenzene with iron powder in the presence of ferrous sulfate.
Synthesis Reference(s)
Tetrahedron Letters, 36, p. 7313, 1995 DOI: 10.1016/0040-4039(95)01474-V
General Description
Colorless to light amber liquid with a sweet odor.
Air & Water Reactions
Sensitive to prolonged exposure to air and light and tends to darken during storage. Insoluble in water.
Reactivity Profile
3-Chloroaniline is incompatible with acids, acid chlorides, acid anhydrides, chloroformates and strong oxidizing agents.
Fire Hazard
3-Chloroaniline is combustible.
Flammability and Explosibility
Non flammable
Safety Profile
Poison by ingestion, skin contact, subcutaneous, and intravenous routes. Mutation data reported. When heated to decomposition it emits toxic fumes of Cland NOx. See also ANILINE DYES.
3-Chloroaniline Preparation Products And Raw materials
Raw materials
Preparation Products
3-Chloroaniline Suppliers
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View Lastest Price from 3-Chloroaniline manufacturers
- Product
- 3-Chloroaniline 108-42-9
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-11-18
- Product
- 3-Chloroaniline 108-42-9
- Price
- US $30.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20T
- Release date
- 2023-10-07
- Product
- 3-Chloroaniline 108-42-9
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 50000KG/month
- Release date
- 2023-06-20