ChemicalBook > CAS DataBase List > 3-Chloroaniline

3-Chloroaniline

Product Name
3-Chloroaniline
CAS No.
108-42-9
Chemical Name
3-Chloroaniline
Synonyms
M-CHLOROANILINE;3-CHLOROBENZENAMINE;ORANGE GC BASE;1,3-aminochlorobenzene;oroaniL;CI 37005;3-Chloranilin;3-Cloroaniline;m-Chloraniline;3-Chloraniline
CBNumber
CB9697982
Molecular Formula
C6H6ClN
Formula Weight
127.57
MOL File
108-42-9.mol
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3-Chloroaniline Property

Melting point:
−11-−9 °C(lit.)
Boiling point:
95-96 °C11 mm Hg(lit.)
Density 
1.206 g/mL at 25 °C(lit.)
vapor pressure 
1 mm Hg ( 63.5 °C)
refractive index 
n20/D 1.594(lit.)
Flash point:
255 °F
storage temp. 
Store below +30°C.
solubility 
6.2g/l
form 
Liquid
pka
3.46(at 25℃)
color 
Clear pale yellow to brown
PH
7.3 (H2O)(saturated aqueous solution)
Odor
Characteristic odour
Water Solubility 
6.8 g/L (20 ºC)
Decomposition 
190°C
Merck 
14,2118
BRN 
605969
Dielectric constant
13.4（19℃）
Stability:
Material darkens in storage with no loss in purity, Material Darkens In Storage
LogP
0.77-2.03 at 25-30℃
CAS DataBase Reference
108-42-9(CAS DataBase Reference)
NIST Chemistry Reference
m-Chloroaniline(108-42-9)
EPA Substance Registry System
m-Chloroaniline (108-42-9)
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Safety

Hazard Codes 
T,N
Risk Statements 
23/24/25-33-50/53
Safety Statements 
28-36/37-45-60-61-28A
RIDADR 
UN 2019 6.1/PG 2
WGK Germany 
2
RTECS 
BX0350000
F 
8-10-23
Autoignition Temperature
705 °C
Hazard Note 
Toxic
TSCA 
Yes
HazardClass 
6.1
PackingGroup 
II
HS Code 
29214210
Hazardous Substances Data
108-42-9(Hazardous Substances Data)
Toxicity
LD50 orally in Rabbit: 256 mg/kg LD50 dermal Rat 250 mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H317May cause an allergic skin reaction

H319Causes serious eye irritation

H330Fatal if inhaled

H373May cause damage to organs through prolonged or repeated exposure

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P314Get medical advice/attention if you feel unwell.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
C22407
Product name
3-Chloroaniline
Purity
99%
Packaging
5g
Price
$40.2
Updated
2024/03/01
Sigma-Aldrich
Product number
C22407
Product name
3-Chloroaniline
Purity
99%
Packaging
100g
Price
$55
Updated
2024/03/01
TCI Chemical
Product number
C0110
Product name
3-Chloroaniline
Purity
>99.0%(GC)
Packaging
25mL
Price
$18
Updated
2024/03/01
TCI Chemical
Product number
C0110
Product name
3-Chloroaniline
Purity
>99.0%(GC)
Packaging
500mL
Price
$93
Updated
2024/03/01
Alfa Aesar
Product number
A12019
Product name
3-Chloroaniline, 99%
Packaging
100g
Price
$36.1
Updated
2024/03/01
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3-Chloroaniline Chemical Properties,Usage,Production

Description

m-Chloroaniline is used as an intermediate for pesticides, pharmaceuticals, and dyes. It is produced by lowpressure hydrogenation of 3-chloronitrobenzene in the liquid phase with noble metal and/or noble metal sulfide catalysts. The addition of metal oxides to the reaction helps avoid dehalogenation. The yield is approximately 98 %.

Chemical Properties

3-Chloroaniline is a clear pale yellow to brown liquid, which becomes darker during storage, insoluble in water, but soluble in ethanol, ether and acid solution.

Application

3-Chloroaniline is the intermediate of the herbicide chloraniline, and the intermediate of the pharmaceutical diuretic antihypertensive drug hydrochlorothiazide, and can be used to produce azo dyes.
3-Chloroaniline was the only aniline compound to increase plasmaALT/GPT activity at 48 h. It is employed in the bioaugmentation of activated sludge.

Uses

3-Chlorobenzenamine is used in the synthesis of pyrimidoazepine analogs as serotonin 5-HT2A and 5-HT2C receptor ligands for the treatment of obesity. Also used in the synthesis of novel COX-2 inhibito rs.

Preparation

3-Chloroaniline is obtained by reducing 3-Nitrochlorobenzene with iron powder in the presence of ferrous sulfate.

Synthesis Reference(s)

Tetrahedron Letters, 36, p. 7313, 1995 DOI: 10.1016/0040-4039(95)01474-V

General Description

Colorless to light amber liquid with a sweet odor.

Air & Water Reactions

Sensitive to prolonged exposure to air and light and tends to darken during storage. Insoluble in water.

Reactivity Profile

3-Chloroaniline is incompatible with acids, acid chlorides, acid anhydrides, chloroformates and strong oxidizing agents.

Fire Hazard

3-Chloroaniline is combustible.

Flammability and Explosibility

Non flammable

Safety Profile

Poison by ingestion, skin contact, subcutaneous, and intravenous routes. Mutation data reported. When heated to decomposition it emits toxic fumes of Cland NOx. See also ANILINE DYES.

3-Chloroaniline Preparation Products And Raw materials

Raw materials

Sodium sulfide Ferrous 1-Chloro-3-nitrobenzene

Preparation Products

FAST ORANGE GC SALT Miconazole nitrate 4-AMINO-6-CHLORO-BENZENE-1,3-DISULFONYL DICHLORIDE 1-(3-Chlorophenyl)-4-(3-chloropropyl)piperazine hydrochloride 4-BROMO-3-CHLOROACETANILIDE 3-Chlorophenyl isocyanate 7-CHLORO-4-HYDROXY-QUINOLINE-3-CARBOXYLIC ACID METHYL ESTER Febantel Fluorescent brightener No.31 1-(3-Chlorophenyl)piperazine dihydrochloride BARBAN Hydrochlorothiazide 3-CHLORODIPHENYLAMINE Clofenamic acid 5-CHLORO-2-(TRIFLUOROMETHYL)QUINOLINE-4-CARBOXYLIC ACID 3-Chlorophenol 7-Chloroquinolin-4-ol 3-CHLOROANILINE HYDROCHLORIDE 1,3-Dichlorobenzene 7-CHLORO-4-HYDROXY-3-QUINOLINECARBOXYLIC ACID Fenbendazole 4-Amino-6-chlorobenzene-1,3-disulfonamide diethyl [(m-chloroanilino)methylene]malonate
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3-Chloroaniline Suppliers

Americas 1 Belgium 3 Canada 4 China 288 Europe 5 France 2 Germany 11 India 73 Indonesia 1 Italy 1 Japan 11 Slovakia 1 South Korea 2 Switzerland 3 The Netherlands 3 Ukraine 2 United Kingdom 17 United States 57 Global 485
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View Lastest Price from 3-Chloroaniline manufacturers

Firsky International Trade (Wuhan) Co., Ltd
Product
3-Chloroaniline 108-42-9
Price
US $30.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20T
Release date
2023-10-07
Hebei Mojin Biotechnology Co., Ltd
Product
3-Chloroaniline 108-42-9
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-06-20
XINGTAI XINGJIU NEW MATERIAL TECHNOLOGY CO., LTD
Product
3-Chloroaniline 108-42-9
Price
US $30.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500MT/month
Release date
2021-12-29

108-42-9, 3-ChloroanilineRelated Search:

2-Chloroaniline 1-Chloro-3-nitrobenzene 6-Aminocaproic acid 2,5-Dichloroaniline Tris(hydroxymethyl)aminomethane Metanilic acid 3-Aminobenzenesulfonamide 3-Aminoacetophenone Glycine 3-Aminophenol 1,3-Dichlorobenzene EC 2.6.1.2 2,6-Dichloroaniline 3,4-Dichloroaniline Chlorobenzene ALTRENOGEST Acetaminophen p-Anisidine

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