3,5-DIBROMO-1-METHYL-1H-PYRIDIN-2-ONE

Uses

Product Name: 3,5-DIBROMO-1-METHYL-1H-PYRIDIN-2-ONE
CAS No.: 14529-54-5
Chemical Name: 3,5-DIBROMO-1-METHYL-1H-PYRIDIN-2-ONE
Synonyms: EOS-61805;3,5-DIBROMOPYRIDINE-2-OL, 98+%;3,5-dibroMo-1-Methyl-2-pyridone;3,5-Dibromo-1-methylpyridin-2-one;5-DIBROMO-1-METHYL-1H-PYRIDIN-2-ONE;3,5-dibromo-1-methyl-2(1H)-Pyridinone;3,5-DibroMo-1-Methyl-1H-pyrazin-2-one;3,5-DIBROMO-1-METHYLPYRIDIN-2(1H)-ONE;3,5-DIBROMO-1-METHYL-1H-PYRIDIN-2-ONE;2(1H)-Pyridinone, 3,5-dibromo-1-methyl-
CBNumber: CB9709100
Molecular Formula: C6H5Br2NO
Formula Weight: 266.92
MOL File: 14529-54-5.mol

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3,5-DIBROMO-1-METHYL-1H-PYRIDIN-2-ONE Property

Melting point:: 182 °C
Boiling point:: 259.4±40.0 °C(Predicted)
Density: 2.130±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
pka: -3.58±0.62(Predicted)
Appearance: Off-white to gray Solid
InChI: InChI=1S/C6H5Br2NO/c1-9-3-4(7)2-5(8)6(9)10/h2-3H,1H3
InChIKey: AOJAJTJZSBVNPU-UHFFFAOYSA-N
SMILES: C1(=O)N(C)C=C(Br)C=C1Br

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

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N-Bromosuccinimide Price

TRC

Product number: D425925
Product name: 3,5-Dibromo-1-methylpyridin-2(1h)-one
Packaging: 25mg
Price: $45
Updated: 2021/12/16

TRC

Product number: D425925
Product name: 3,5-Dibromo-1-methylpyridin-2(1h)-one
Packaging: 250mg
Price: $75
Updated: 2021/12/16

Ark Pharm

Product number: P000724729
Product name: 3,5-Dibromo-1-methylpyridin-2(1H)-one
Purity: 97%
Packaging: 5g
Price: $100
Updated: 2021/12/16

AK Scientific

Product number: J98923
Product name: 3,5-Dibromo-1-methylpyridin-2(1H)-one
Packaging: 5g
Price: $130
Updated: 2021/12/16

Ark Pharm

Product number: P000724729
Product name: 3,5-Dibromo-1-methylpyridin-2(1H)-one
Purity: 97%
Packaging: 10g
Price: $167
Updated: 2021/12/16

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3,5-DIBROMO-1-METHYL-1H-PYRIDIN-2-ONE Chemical Properties,Usage,Production

Uses

3,5-Dibromo-1-methylpyridine-2(1H)-one is a ketone organic compound that can be used as a pharmaceutical intermediate.

Synthesis

13472-81-6

74-88-4

14529-54-5

General procedure for the synthesis of 3,5-dibromo-1-methylpyridin-2(1H)-one from 3,5-dibromo-2-hydroxypyridine and iodomethane: 3,5-dibromo-1H-pyridin-2-one (5 g, 19.8 mmol) was dissolved in DMF (170 mL), K2CO3 (6.01 g, 43.5 mmol) was added and the suspension was stirred for 15 min. Subsequently, MeI (1.36 mL, 21.8 mmol) was added dropwise to the reaction system and the reaction was stirred at room temperature for 18 hours. After completion of the reaction, water (200 mL) was added to the mixture and the aqueous layer was extracted with EtOAc (3 x 200 mL). The organic layers were combined, dried with Na2SO4, filtered and concentrated under reduced pressure. The resulting solid was ground with Et2O to give 3,5-dibromo-1-methylpyridin-2(1H)-one (2 g). The filtrate was evaporated under reduced pressure and the residue was ground with Et2O to give a second product (2.0 g). The filtrate was further concentrated and purified by fast chromatography on silica gel, using a solvent mixture of EtOAc and hexane as eluent, to give finally 3,5-dibromo-1-methylpyridin-2(1H)-one (4.5 g total, 85% yield). The product was characterized by 1H NMR (500 MHz, CDCl3): δ 7.78 (d, J=2.5 Hz, 1H), 7.42 (d, J=2.5 Hz, 1H), 3.59 (s, 3H). Mass spectra (ESI) showed [M+H]+ peaks of 266.01, 267.99, 269.99.

References

[1] Patent: WO2017/24412, 2017, A1. Location in patent: Page/Page column 65
[2] Patent: US2008/153834, 2008, A1. Location in patent: Page/Page column 20-21
[3] Patent: WO2008/33858, 2008, A2. Location in patent: Page/Page column 127-128
[4] Patent: WO2008/33858, 2008, A2. Location in patent: Page/Page column 127-128

3,5-DIBROMO-1-METHYL-1H-PYRIDIN-2-ONE Preparation Products And Raw materials

Raw materials

Preparation Products

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3,5-DIBROMO-1-METHYL-1H-PYRIDIN-2-ONE Suppliers

China 143 Germany 2 India 3 Switzerland 1 United Kingdom 1 United States 12 Global 162

Changzhou Kangrui Pharmaceutical Technology Co., Ltd.

Tel: +86-0519-85485169 +86-13961161173
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Beijing Ouhe Technology Co., Ltd

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Tetranov Biopharm

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Accela ChemBio Co.,Ltd.

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Shanghai Hanhong Scientific Co.,Ltd.

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Santai Labs, Inc.

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skychemical Co.Ltd

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Shanghai Sunway Pharmaceutical Technology Co., Ltd

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Changzhou Wanyao Biotechnology Co., Ltd.

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View Lastest Price from 3,5-DIBROMO-1-METHYL-1H-PYRIDIN-2-ONE manufacturers

Dideu Industries Group Limited

Product: 3,5-DIBROMO-1-METHYL-1H-PYRIDIN-2-ONE 14529-54-5
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons min
Release date: 2021-08-31

Career Henan Chemical Co

Product: 3,5-DIBROMO-1-METHYL-1H-PYRIDIN-2-ONE 14529-54-5
Price: US $1.00/kg
Min. Order: 1kg
Purity: 95%-99%
Supply Ability: 100kg
Release date: 2018-12-24

14529-54-5, 3,5-DIBROMO-1-METHYL-1H-PYRIDIN-2-ONERelated Search:

2-Pyridinecarboxaldehyde,3,5-dimethyl-(9CI) (3,5-DIFLUOROPYRIDIN-4-YL)BORONIC ACID 3,5-Dichloro-4-Methoxy-pyridine 3,5-DIAMINOBENZONITRILE 3,5-DIBROMO-4-PYRIDINOL 3,5-Dichloro-4-hydroxypyridine 3,5-Dichloro-2(1H)-pyrazinone ETHYL 3,5-DIBROMOISONICOTINATE 3,5-Difluoro-4-pyridinecarboxaldehyde 2-Pyridinecarboxylicacid,3,5-dimethyl-(9CI) 3,5-DIBROMO-4-METHOXYPYRIDINE-N-OXIDE 1,3-DIBROMO-1-PROPENE 3,5-Dibromopyridine B-DIMETHYLAMINOETHYL BROMIDE HYDROBROMIDE 5-BROMO-1-METHYL-2(1H)-PYRIDINONE 3,5-DIBROMO-1,6-DIMETHYL-1H-PYRIDIN-2-ONE 3,5-DIBROMO-1-METHYL-1H-PYRIDIN-2-ONE 1-BENZYL-3,5-DIBROMO-6-METHYL-1H-PYRIDIN-2-ONE

3,5-DIBROMO-1-METHYL-1H-PYRIDIN-2-ONE

3,5-DIBROMO-1-METHYLPYRIDIN-2(1H)-ONE

3,5-DIBROMOPYRIDINE-2-OL, 98+%

3,5-dibroMo-1-Methyl-1,2-dihydropyridin-2-one

3,5-dibroMo-1-Methyl-2-pyridone

3,5-dibromo-1-methyl-2(1H)-Pyridinone

N-naphthalen-2-yl-5-oxopyrrolidine-2-carboxamide

3,5-Dibromo-1-methylpyridin-2-one

EOS-61805

3,5-DibroMo-1-Methyl-1H-pyrazin-2-one

5-DIBROMO-1-METHYL-1H-PYRIDIN-2-ONE

2(1H)-Pyridinone, 3,5-dibromo-1-methyl-

3,5-DIBROMO-1-METHYL-1H-PYRIDIN-2-ONE ISO 9001：2015 REACH

3, 5-dibromo-1-methylpyridine-2 (1H) -ketone

14529-54-5