ChemicalBook > CAS DataBase List > Boc-Dap-OH

Boc-Dap-OH

Product Name
Boc-Dap-OH
CAS No.
73259-81-1
Chemical Name
Boc-Dap-OH
Synonyms
BOC-L-DAP-OH;(S)-3-AMINO-2-(TERT-BUTOXYCARBONYLAMINO)PROPANOIC ACID;BOC-L-DAP;BOC-DPR-OH;BOC-DAP-OH;Boc-Dapa-OH;BOC-L-DAPA-OH;(N-Boc-β-amino)-AL;3-Amino-Boc-L-alanin;Boc-Dap-OH USP/EP/BP
CBNumber
CB9715251
Molecular Formula
C8H16N2O4
Formula Weight
204.22
MOL File
73259-81-1.mol
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Boc-Dap-OH Property

Melting point:
210 °C (dec.)
alpha 
-5.5 º (c=1, acetic acid)
Boiling point:
364.4±37.0 °C(Predicted)
Density 
1.189±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,2-8°C
solubility 
DMSO (Slightly, Heated, Sonicated), Water (Sparingly, Heated, Sonicated)
form 
Solid
pka
2.88±0.16(Predicted)
color 
White to Off-White
optical activity
[α]20/D +5.5±1°, c = 1% in methanol: water (1:1)
BRN 
4182136
InChI
InChI=1S/C8H16N2O4/c1-8(2,3)14-7(13)10-5(4-9)6(11)12/h5H,4,9H2,1-3H3,(H,10,13)(H,11,12)/t5-/m0/s1
InChIKey
KRJLRVZLNABMAT-YFKPBYRVSA-N
SMILES
C(O)(=O)[C@H](CN)NC(OC(C)(C)C)=O
CAS DataBase Reference
73259-81-1(CAS DataBase Reference)
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Safety

Safety Statements 
24/25
WGK Germany 
3
F 
10
HazardClass 
IRRITANT
HS Code 
29241990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H225Highly Flammable liquid and vapour

H260In contact with water releases flammable gases which may ignite spontaneously

H302Harmful if swallowed

H314Causes severe skin burns and eye damage

H335May cause respiratory irritation

H336May cause drowsiness or dizziness

H361Suspected of damaging fertility or the unborn child

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P223Keep away from any possible contact with water, because of violent reaction and possible flash fire.

P231+P232Handle under inert gas. Protect from moisture.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P242Use only non-sparking tools.

P243Take precautionary measures against static discharge.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P308+P313IF exposed or concerned: Get medical advice/attention.

P335+P334Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.

P363Wash contaminated clothing before reuse.

P370+P378In case of fire: Use … for extinction.

P402+P404Store in a dry place. Store in a closed container.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P403+P235Store in a well-ventilated place. Keep cool.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
15402
Product name
Boc-Dap-OH
Purity
≥98.0% (TLC)
Packaging
1g
Price
$86.8
Updated
2024/03/01
Sigma-Aldrich
Product number
15402
Product name
Boc-Dap-OH
Purity
≥98.0% (TLC)
Packaging
5g
Price
$390
Updated
2024/03/01
TCI Chemical
Product number
A2470
Product name
(S)-3-Amino-2-(tert-butoxycarbonylamino)propionic Acid
Purity
>95.0%(HPLC)(T)
Packaging
1g
Price
$25
Updated
2024/03/01
TCI Chemical
Product number
A2470
Product name
(S)-3-Amino-2-(tert-butoxycarbonylamino)propionic Acid
Purity
>95.0%(HPLC)(T)
Packaging
5g
Price
$72
Updated
2024/03/01
Alfa Aesar
Product number
H26919
Product name
N(alpha)-Boc-L-2,3-diaminopropionic acid, 97%
Packaging
1g
Price
$63.65
Updated
2024/03/01
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Boc-Dap-OH Chemical Properties,Usage,Production

Chemical Properties

White powder

Uses

Reactant for:

  • Protein assembly directed by synthetic molecular recognition motifs
  • Solid phase synthesis of gramicidin S cyclic analogs with antibiotic and hemolytic activities
  • Synthesis of HCV protease inhibitor modified analogs
  • Solid phase synthesis of peptidic V1a receptor agonists
  • Directed peptide assembly at lipid-water interface

Uses

(S)-3-amino-2-(tert-Butoxycarbonylamino)propionic acid (Boc-Dap-OH) is a derivative of amino acids, mainly used as an intermediate in organic synthesis and pharmaceutical chemistry, and can be used in the synthesis of peptide drug molecules and bioactive molecules.

Preparation

The raw material was dissolved inabsolute ethanol (5 mL), and the reaction flask was immersed in a water bath at 25 C. To the alcoholicsolution, 10% palladium-carbon (22.9 mg) and 1,4-cyclohexadiene (10 equivalents with respect to4; 0.47 mL, 5.0 mmol) were added, and the mixture was allowed to react under magnetic stirringovernight. After filtration over a short pad of Celite 545, the solvent was evaporated under reducedpressure conditions, and the solid residue was partitioned in a 1:1 (v/v) H2O/EtOAc mixture (10 mL).The aqueous phase was separated, back extracted with EtOAc (3 10 mL), concentrated under reducedpressure conditions, and lyophilized.Finally, the target product Boc-Dap-OH is obtained.

Definition

Boc-Dap-OH is an amino acid molecule that is a zwitterion. Therefore, the addition of a base is required to prepare a nucleophilic amino acid. It is commonly acts as a nucleophile to attack the acyl carbon.

Boc-Dap-OH Preparation Products And Raw materials

Raw materials

Preparation Products

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Boc-Dap-OH Suppliers

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View Lastest Price from Boc-Dap-OH manufacturers

Sichuan HongRi Pharma-Tech Co.,Ltd
Product
Boc-L-Dap-OH 73259-81-1
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1T+
Release date
2023-09-24
Sichuan Jiaying Lai Technology Co.,LTD
Product
Boc-Dap-OH 73259-81-1
Price
US $1.00/g
Min. Order
1g
Purity
98%
Supply Ability
100KG
Release date
2019-07-18
Sichuan Jiaying Lai Technology Co.,LTD
Product
Boc-Dap-OH 73259-81-1
Price
US $1.00/g
Min. Order
1g
Purity
98%
Supply Ability
100KG
Release date
2019-07-18

73259-81-1, Boc-Dap-OHRelated Search:

Cbz-beta-Amino-L-alanine (S)-1-N-BOC-4-N-FMOC-PIPERAZINE-2-CARBOXYLIC ACID (S)-N-1-Boc-N-4-Cbz-2-piperazine carboxylic acid (S)-4-Boc-Piperazine-3-carboxylic acid Boc-Dap-OH (S)-1-N-Boc-piperazine-2-carboxylic acid methyl ester 2,3-Diaminopropionic acid L-2,3-Diaminopropionic acid BOC-DAP(DNP)-OH BOC-L-DPA(BOC)-OH BOC-DAP(FMOC)-OH BOC-AZA-L-LEUCINE BOC-ALBIZZIIN BOC-BETA-N-BENZYLAMINO-L-ALA BOC-DAP(DNP)-OSU BOC-DAP(ALOC)-OH DCHA BOC-DAP(BOC)-OH DCHA BOC-DAP(ALOC)-OH

  • N-Boc-beta-amino-L-alanine
  • (2S)-3-amino-2-{[(tert-butoxy)carbonyl]amino}propanoic acid
  • N-alpha-L-(Butoxycarbonyl)-2,3-diaMinopropionic aci
  • 3-Amino-N-(tert-butoxycarbonyl)-L-alanine 97%
  • 3-Amino-Boc-L-alanin
  • Boc-Dapa-OH
  • 3-AMINO-(TERT-BUTOXYCARBONYL)-L-ALANINE
  • Nα-Boc-L-2,3-diaminopropionic acid≥ 98% (HPLC)
  • L-ALANINE, 3-AMINO-N-[(1,1-DIMETHYLETHOXY)CARBONYL]-
  • BOC-L-DAP-OH
  • BOC-L-DAPA-OH
  • BOC-L-2,3-DIAMINOPROPIONIC ACID
  • BOC-L-ALPHA,BETA-DIAMINOPROPIONIC ACID
  • BOC-DPR-OH
  • BOC-DAP-OH
  • BOC-ALPHA,BETA-DIAMINOPROPIONIC ACID
  • (S)-3-AMINO-2-(TERT-BUTOXYCARBONYLAMINO)PROPANOIC ACID
  • T-BUTYLOXYCARBONYL-L-2,3-DIAMINOPROPIONIC ACID
  • N-ALPHA-BOC-(S)-2,3-DIAMINOPROPIONIC ACID
  • NALPHA-BOC-L-BETA-AMINOALANINE
  • N-ALPHA-BOC-L-DIAMINOPROPIONIC ACID
  • N-ALPHA-BOC-L-2,3-DIAMINOPROPIONIC ACID
  • N-ALPHA-BOC-BETA-AMINO-L-ALANINE
  • Boc-Dap-OH(Na-Boc-2,3-DiaMinopropionic acid)
  • 3-[(tert-butoxy)(carbaMoyl)aMino]propanoic acid
  • Nalpha-BOC-beta-AMino-L-alanine, 97% 1GR
  • Nalpha-Boc-2,3-diaminopropionic Acid 3-Amino-N-(tert-butoxycarbonyl)-L-alanine 3-Amino-N-Boc-L-alanine Boc-Dap-OH Boc-Dpr-OH
  • (<i>S</i>)-3-AMino-2-Boc-propionic acid
  • N2-tertbutoxycarbonyl-L-2,3-diaMinopropanoic acid
  • (S)-3-AMino-2-Boc-propionic acid
  • 3-Amino-N-(tert-butoxycarbonyl)-L-alanine
  • (S)-2-(AMinoMethyl)-4-(tert-butoxy)-4-oxobutanoic acid
  • (S)-2-[(tert-Butoxycarbonyl)amino]-3-aminopropionic acid
  • N2-(tert-Butoxycarbonyl)-(S)-2,3-diaminopropionic acid
  • N2-tert-Butoxycarbonyl-L-2,3-diaminopropionic acid
  • Nα-BOC-(S)-β-aminoalanine
  • Nα-Boc-L-β-aminoalanine
  • (Tert-Butoxy)Carbonyl Dap-OH
  • (S)-3-AMino-Boc-Alanine
  • N-ALPHA-T-BUTOXYCARBONYL-L-ALPHA,BETA-DIAMINOPROPIONIC ACID
  • N-ALPHA-L-(BUTOXYCARBONYL)2,3-DIAMINOPROPIONIC ACID
  • N-ALPHA-TERT-BUTYLOXYCARBONYL-L-2,3-DIAMINOPROPIONIC ACID
  • (N-BOC-BETA-AMINO)-ALA-OH
  • N-T-BOC-BETA-AMINO-L-ALANINE
  • Boc-Dpr-OH, N-Boc-L-2,3-diaminopropanoic acid
  • Na-Boc-L-2,3-diaminopropionic acid
  • N-t-BOC-?amino-L-alanine
  • N-BOC-L-2,3-DIAMINOPROPANOIC ACID
  • (n-boc-β-amino)-ala-oh
  • BOC-L-DAP-OH BOC-L-2,3- DIAMINOPROPIONIC ACID
  • N-ALPHA-T-BUTYLOXYCARBONYL-L-2,3-DIAMINOPROPIONIC ACID
  • NALPHA-tert-Butoxycarbonyl-L-2,3-diaminopropionic acid
  • N-ALPHA-L-(BUTOXYCARBONYL)-2,3-DIAMINOPROPIONIC
  • N-TERT-BOC-BETA-AMINO-L-ALANINE
  • 3-Amino-Boc-L-alanine
  • N(ɑ)-Boc-L-2,3-diaminopropionic acid, 97%
  • 3-Amino-(tert-butoxycarbonyl)-L-alanine, Boc-Dap-OH, Boc-Dpr-OH, (S)-3-Amino-2-(tert-butoxycarbonylamino)propanoic acid, Nα-Boc-L-2,3-diaminopropionic acid
  • 3-Amino-(tert-butoxycarbonyl)-L-alanine, Boc-Dpr-OH, (S)-3-Amino-2-(tert-butoxycarbonylamino)propanoic acid, Nα-Boc-L-2,3-diaminopropionic acid