Cbz-beta-Amino-L-alanine

Product Name: Cbz-beta-Amino-L-alanine
CAS No.: 35761-26-3
Chemical Name: Cbz-beta-Amino-L-alanine
Synonyms: Z-DAP-OH;Cbz-Dap-OH;H-DAP(Z)-OH;CBZ-DAP;Z-L-DAP;Z-DPR-OH;Z-Dap-0H;CBZ-L-DAP;Z-L-DAP-OH;CBZ-L-DAP-OH
CBNumber: CB5677483
Molecular Formula: C11H14N2O4
Formula Weight: 238.24
MOL File: 35761-26-3.mol

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Cbz-beta-Amino-L-alanine Property

Melting point:: ~240 °C (dec.)
alpha: -39 º (1%, 1N HCl)
Boiling point:: 463.8±45.0 °C(Predicted)
Density: 1.303±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: Soluble in dilute acid.
form: Solid
pka: 2.86±0.16(Predicted)
color: White
optical activity: [α]20/D 39±1°, c = 1% in 1 M HCl
Sensitive: Hygroscopic
BRN: 4486950
InChI: InChI=1S/C11H14N2O4/c12-6-9(10(14)15)13-11(16)17-7-8-4-2-1-3-5-8/h1-5,9H,6-7,12H2,(H,13,16)(H,14,15)/t9-/m0/s1
InChIKey: FOXRXVSTFGNURG-VIFPVBQESA-N
SMILES: C(O)(=O)[C@H](CN)NC(OCC1=CC=CC=C1)=O
CAS DataBase Reference: 35761-26-3(CAS DataBase Reference)

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Safety

Safety Statements: 22-24/25
WGK Germany: 3
F: 3
HS Code: 2922.49.3700
HazardClass: IRRITANT

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 96085
Product name: Z-Dap-OH
Purity: ≥98.0% (NT)
Packaging: 5g
Price: $382
Updated: 2023/06/20

TCI Chemical

Product number: A2471
Product name: (S)-3-Amino-2-(carbobenzoxyamino)propionic Acid
Purity: >98.0%(HPLC)(T)
Packaging: 1g
Price: $19
Updated: 2024/03/01

TCI Chemical

Product number: A2471
Product name: (S)-3-Amino-2-(carbobenzoxyamino)propionic Acid
Purity: >98.0%(HPLC)(T)
Packaging: 5g
Price: $48
Updated: 2024/03/01

Usbiological

Product number: C1102-02
Product name: Na-Carbobenzyloxy-b-amino-L-alanine
Packaging: 1g
Price: $312
Updated: 2021/12/16

TRC

Product number: C176175
Product name: Nα-Carbobenzyloxy-β-amino-L-alanine
Packaging: 100g
Price: $790
Updated: 2021/12/16

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Cbz-beta-Amino-L-alanine Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

Nalpha-Benzyloxycarbonyl-L-2,3-diaminopropionic acid is a important building block for the synthesis of peptides containing DAP residues, e.g. bleomycins, edeines, tuberactinomycins.

reaction suitability

reaction type: solution phase peptide synthesis

Synthesis

16947-84-5

35761-26-3

The general procedure for the synthesis of N(alpha)-Z-L-2,3-diaminopropionic acid from (S)-2-(((benzyloxy)carbonyl)amino)-3-((tert-butoxycarbonyl)amino)propionic acid is as follows: 50 g of (S)-N-benzyloxycarbonyl-N'-tert-butoxycarbonyl-2,3-diaminopropionic acid was dissolved in 500 mL of methylene chloride, followed by 50 mL of trifluoroacetic acid. The reaction mixture was stirred at 50 °C for the reaction and subsequently left at room temperature overnight. Upon completion of the reaction, the reaction mixture was concentrated to dryness by rotary evaporator and the evaporation process was repeated to completely remove the solvent.

References

[1] Collection of Czechoslovak Chemical Communications, 1976, vol. 41, p. 2969 - 2977
[2] Patent: CN108452321, 2018, A. Location in patent: Paragraph 0113; 0114; 0115; 0116

Cbz-beta-Amino-L-alanine Preparation Products And Raw materials

Raw materials

Preparation Products

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Cbz-beta-Amino-L-alanine Suppliers

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View Lastest Price from Cbz-beta-Amino-L-alanine manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: Cbz-beta-Amino-L-alanine 35761-26-3
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-14

Career Henan Chemical Co

Product: Cbz-beta-Amino-L-alanine 35761-26-3
Price: US $3.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 100kg
Release date: 2019-07-04

35761-26-3, Cbz-beta-Amino-L-alanineRelated Search:

L-N-Cbz-3-N-Boc-Amino-alanine Boc-Dap-OH (S)-3-AMINO-2-CBZ-AMINO-PROPIONIC ACID TERT-BUTYL ESTER AC-HIS-OH H2O Fmoc-Lys(Boc)-OH Z-DAP(FMOC)-OH Cbz-beta-Amino-L-alanine (S)-N-4-BOC-N-1-CBZ-2-PIPERAZINE CARBOXYLIC ACID (S)-Methyl 2-N-Cbz-3-N-Boc-propanoate CBZ-BETA-AMINO-D-ALANINE L-Alanine L-2,3-Diaminopropionic acid DL-2-AMINOPROPIONIC ANHYDRIDE 2,3-Diaminopropionic acid METHYL 2-(S)-[N-CARBOBENZYLOXY]AMINO-3-AMINOPROPIONATE, HYDROCHLORIDE Z-DAP(Z)-OH (S)-(-)-2-OXO-1,5-IMIDAZOLIDINEDICARBOXYLIC ACID 1-BENZYL ESTER Z-L-DAP(BOC)-OBN

L-ALANINE, 3-AMINO-N-[(PHENYLMETHOXY)CARBONYL]-

Z-Dap-OH >=98.0% (NT)

Nα-Z-L-2,3-diaminopropionic acid≥ 98% (Assay)

CBZ-BETA-AMINO-L-ALANINE

CBZ-L-B-AMINOALANINE

CBZ-L-DAP-OH

H-DAP(Z)-OH

3-AMINO-2-BENZYLOXYCARBONYLAMINO-PROPIONIC ACID

Z-L-DAP-OH

Z-L-2,3-DIAMINOPROPIONIC ACID

Z-DPR-OH

Z-ALPHA,BETA-DIAMINOPROPIONIC ACID

Z-DAP-OH

(S)-3-AMINO-2-BENZYLOXYCARBONYLAMINO-PROPIONIC ACID

N-BETA-CARBOBENZOXY-L-ALPHA, BETA-DIAMINOPROPIONIC ACID

NA-BENZYLOXYCARBONYL-L-2,3-DIAMIOPROPIONIC ACID

NA-CARBOBENZYLOXY-B-AMINO-L-ALANINE

N-ALPHA-CARBOBENZOXY-L-ALPHA,BETA-DIAMINOPROPIONIC ACID

N-ALPHA-BENZYLOXYCARBONYL-L-2,3-DIAMINOPROPIONIC ACID

N-ALPHA-CBZ-L-2,3-DIAMINOPROPIONIC ACID

N-ALPHA-Z-L-2,3-DIAMINOPROPIONIC ACID

3-Amino-N-Cbz-L-alanine

(2S)-3-amino-2-{[(benzyloxy)carbonyl]amino}propanoic acid

3-Amino-N-benzyloxycarbonyl-L-alanine

CBZ-L-DAP

Cbz-beta-Amino-L-ala

NALPHA-Z-L-ALPHA,BETA-DIAMINOPROPIONIC ACID

3-AMINO-2-N-CBZ-L-ALANINE

NA-BENZYLOXYCARBONYL-L-2,3-DIAMINOPROPIONICACID

Z-L-DAP-OH CBZ-L-2,3- DIAMINOPROPIONIC ACID

Cbz-L-2,3-DiaminopropionicAcid

Nalpha-Carbobenzyloxy-beta-amino-L-alanine

N-A-CBZ-L-2,3-DIAMINOPROPIONICACID

(S)-3-amino-2-N-Cbz-propanoic acid

CBZ-L--Aminoalanine

Z-Dpr-OH, Nα-Z-L-2,3-Diaminopropionic acid

N<sub>α</sub>-Z-L-2,3-Diaminopropionic acid

Nα-L-α,β- diaminopropionic acid

Cbz-Dap-OH

(S)-3-amino-2-(benzyloxycarbonylamino)propanoic acid

Nα-Carbobenzyloxy-β-amino-L-alanine

CBZ-DAP

(S)-3-AMino-2-(carbobenzoxyaMino)propionic Acid

(S)-2-(BenzyloxycarbonylaMino)-3-aMinopropionic Acid

3-AMino-N-[(phenylMethoxy)carbonyl]-L-alanine

(S)-Nalpha-Cbz-2,3-diaminopropionic Acid 3-Amino-N-(carbobenzoxy)-L-alanine 3-Amino-N-Cbz-L-alanine Z-Dap-OH Z-Dpr-OH

Cbz-β-aMino-L-alanine

Z-Dap-OH(Na-Boc-2,3-DiaMinopropionic acid)

Z-L-DAP

(S)-3-Amino-2-(carbobenzoxyamino)propionic Acid &gt

(S)-3-Amino-2-(benzyloxycarbonylamino)-propanoicaci

(S)-Nalpha-Cbz-2,3-diaminopropionic Acid

3-Amino-N-(carbobenzoxy)-L-alanine

Cbz-beta-Amino-L-alanine USP/EP/BP

Nα-Benzyloxycarbonyl-L-2,3-diamiopropionic Acid Discontinued See: C176175

(2S)-3-azaniumyl-2-(phenylmethoxycarbonylamino)propanoate

Nα-Z-L-2,3-diaminopropionic acid

(2S)-3-amino-2-benzyloxycarbonylaminopropionic acid