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Cbz-beta-Amino-L-alanine

Product Name
Cbz-beta-Amino-L-alanine
CAS No.
35761-26-3
Chemical Name
Cbz-beta-Amino-L-alanine
Synonyms
Z-DAP-OH;Cbz-Dap-OH;H-DAP(Z)-OH;CBZ-DAP;Z-L-DAP;Z-DPR-OH;Z-Dap-0H;CBZ-L-DAP;Z-L-DAP-OH;CBZ-L-DAP-OH
CBNumber
CB5677483
Molecular Formula
C11H14N2O4
Formula Weight
238.24
MOL File
35761-26-3.mol
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Cbz-beta-Amino-L-alanine Property

Melting point:
~240 °C (dec.)
alpha 
-39 º (1%, 1N HCl)
Boiling point:
463.8±45.0 °C(Predicted)
Density 
1.303±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
Soluble in dilute acid.
form 
Solid
pka
2.86±0.16(Predicted)
color 
White
optical activity
[α]20/D 39±1°, c = 1% in 1 M HCl
Sensitive 
Hygroscopic
BRN 
4486950
InChI
InChI=1S/C11H14N2O4/c12-6-9(10(14)15)13-11(16)17-7-8-4-2-1-3-5-8/h1-5,9H,6-7,12H2,(H,13,16)(H,14,15)/t9-/m0/s1
InChIKey
FOXRXVSTFGNURG-VIFPVBQESA-N
SMILES
C(O)(=O)[C@H](CN)NC(OCC1=CC=CC=C1)=O
CAS DataBase Reference
35761-26-3(CAS DataBase Reference)
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Safety

Safety Statements 
22-24/25
WGK Germany 
3
F 
3
HS Code 
2922.49.3700
HazardClass 
IRRITANT
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
96085
Product name
Z-Dap-OH
Purity
≥98.0% (NT)
Packaging
5g
Price
$382
Updated
2023/06/20
TCI Chemical
Product number
A2471
Product name
(S)-3-Amino-2-(carbobenzoxyamino)propionic Acid
Purity
>98.0%(HPLC)(T)
Packaging
1g
Price
$19
Updated
2024/03/01
TCI Chemical
Product number
A2471
Product name
(S)-3-Amino-2-(carbobenzoxyamino)propionic Acid
Purity
>98.0%(HPLC)(T)
Packaging
5g
Price
$48
Updated
2024/03/01
Usbiological
Product number
C1102-02
Product name
Na-Carbobenzyloxy-b-amino-L-alanine
Packaging
1g
Price
$312
Updated
2021/12/16
TRC
Product number
C176175
Product name
Nα-Carbobenzyloxy-β-amino-L-alanine
Packaging
100g
Price
$790
Updated
2021/12/16
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Cbz-beta-Amino-L-alanine Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

Nalpha-Benzyloxycarbonyl-L-2,3-diaminopropionic acid is a important building block for the synthesis of peptides containing DAP residues, e.g. bleomycins, edeines, tuberactinomycins.

reaction suitability

reaction type: solution phase peptide synthesis

Synthesis

16947-84-5

35761-26-3

The general procedure for the synthesis of N(alpha)-Z-L-2,3-diaminopropionic acid from (S)-2-(((benzyloxy)carbonyl)amino)-3-((tert-butoxycarbonyl)amino)propionic acid is as follows: 50 g of (S)-N-benzyloxycarbonyl-N'-tert-butoxycarbonyl-2,3-diaminopropionic acid was dissolved in 500 mL of methylene chloride, followed by 50 mL of trifluoroacetic acid. The reaction mixture was stirred at 50 °C for the reaction and subsequently left at room temperature overnight. Upon completion of the reaction, the reaction mixture was concentrated to dryness by rotary evaporator and the evaporation process was repeated to completely remove the solvent.

References

[1] Collection of Czechoslovak Chemical Communications, 1976, vol. 41, p. 2969 - 2977
[2] Patent: CN108452321, 2018, A. Location in patent: Paragraph 0113; 0114; 0115; 0116

Cbz-beta-Amino-L-alanine Preparation Products And Raw materials

Raw materials

Preparation Products

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Cbz-beta-Amino-L-alanine Suppliers

Americas 1 Canada 3 China 184 Europe 3 Germany 5 India 5 Japan 4 South Korea 2 Switzerland 5 United Kingdom 9 United States 34 Global 255
TCI AMERICA
Tel
800-4238616
Fax
+1-888-520-1075 / +1-503-283-1987
Email
sales@tciamerica.com
Country
Americas
ProdList
23653
Advantage
75
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View Lastest Price from Cbz-beta-Amino-L-alanine manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
Cbz-beta-Amino-L-alanine 35761-26-3
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-10-14
Career Henan Chemical Co
Product
Cbz-beta-Amino-L-alanine 35761-26-3
Price
US $3.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
100kg
Release date
2019-07-04

35761-26-3, Cbz-beta-Amino-L-alanineRelated Search:

L-N-Cbz-3-N-Boc-Amino-alanine Boc-Dap-OH (S)-3-AMINO-2-CBZ-AMINO-PROPIONIC ACID TERT-BUTYL ESTER AC-HIS-OH H2O Fmoc-Lys(Boc)-OH Z-DAP(FMOC)-OH Cbz-beta-Amino-L-alanine (S)-N-4-BOC-N-1-CBZ-2-PIPERAZINE CARBOXYLIC ACID (S)-Methyl 2-N-Cbz-3-N-Boc-propanoate CBZ-BETA-AMINO-D-ALANINE L-Alanine L-2,3-Diaminopropionic acid DL-2-AMINOPROPIONIC ANHYDRIDE 2,3-Diaminopropionic acid METHYL 2-(S)-[N-CARBOBENZYLOXY]AMINO-3-AMINOPROPIONATE, HYDROCHLORIDE Z-DAP(Z)-OH (S)-(-)-2-OXO-1,5-IMIDAZOLIDINEDICARBOXYLIC ACID 1-BENZYL ESTER Z-L-DAP(BOC)-OBN

  • L-ALANINE, 3-AMINO-N-[(PHENYLMETHOXY)CARBONYL]-
  • Z-Dap-OH >=98.0% (NT)
  • Nα-Z-L-2,3-diaminopropionic acid≥ 98% (Assay)
  • CBZ-BETA-AMINO-L-ALANINE
  • CBZ-L-B-AMINOALANINE
  • CBZ-L-DAP-OH
  • H-DAP(Z)-OH
  • 3-AMINO-2-BENZYLOXYCARBONYLAMINO-PROPIONIC ACID
  • Z-L-DAP-OH
  • Z-L-2,3-DIAMINOPROPIONIC ACID
  • Z-DPR-OH
  • Z-ALPHA,BETA-DIAMINOPROPIONIC ACID
  • Z-DAP-OH
  • (S)-3-AMINO-2-BENZYLOXYCARBONYLAMINO-PROPIONIC ACID
  • N-BETA-CARBOBENZOXY-L-ALPHA, BETA-DIAMINOPROPIONIC ACID
  • NA-BENZYLOXYCARBONYL-L-2,3-DIAMIOPROPIONIC ACID
  • NA-CARBOBENZYLOXY-B-AMINO-L-ALANINE
  • N-ALPHA-CARBOBENZOXY-L-ALPHA,BETA-DIAMINOPROPIONIC ACID
  • N-ALPHA-BENZYLOXYCARBONYL-L-2,3-DIAMINOPROPIONIC ACID
  • N-ALPHA-CBZ-L-2,3-DIAMINOPROPIONIC ACID
  • N-ALPHA-Z-L-2,3-DIAMINOPROPIONIC ACID
  • 3-Amino-N-Cbz-L-alanine
  • (2S)-3-amino-2-{[(benzyloxy)carbonyl]amino}propanoic acid
  • 3-Amino-N-benzyloxycarbonyl-L-alanine
  • CBZ-L-DAP
  • Cbz-beta-Amino-L-ala
  • NALPHA-Z-L-ALPHA,BETA-DIAMINOPROPIONIC ACID
  • 3-AMINO-2-N-CBZ-L-ALANINE
  • NA-BENZYLOXYCARBONYL-L-2,3-DIAMINOPROPIONICACID
  • Z-L-DAP-OH CBZ-L-2,3- DIAMINOPROPIONIC ACID
  • Cbz-L-2,3-DiaminopropionicAcid
  • Nalpha-Carbobenzyloxy-beta-amino-L-alanine
  • N-A-CBZ-L-2,3-DIAMINOPROPIONICACID
  • (S)-3-amino-2-N-Cbz-propanoic acid
  • CBZ-L--Aminoalanine
  • Z-Dpr-OH, Nα-Z-L-2,3-Diaminopropionic acid
  • N<sub>α</sub>-Z-L-2,3-Diaminopropionic acid
  • Nα-L-α,β- diaminopropionic acid
  • Cbz-Dap-OH
  • (S)-3-amino-2-(benzyloxycarbonylamino)propanoic acid
  • Nα-Carbobenzyloxy-β-amino-L-alanine
  • CBZ-DAP
  • (S)-3-AMino-2-(carbobenzoxyaMino)propionic Acid
  • (S)-2-(BenzyloxycarbonylaMino)-3-aMinopropionic Acid
  • 3-AMino-N-[(phenylMethoxy)carbonyl]-L-alanine
  • (S)-Nalpha-Cbz-2,3-diaminopropionic Acid 3-Amino-N-(carbobenzoxy)-L-alanine 3-Amino-N-Cbz-L-alanine Z-Dap-OH Z-Dpr-OH
  • Cbz-β-aMino-L-alanine
  • Z-Dap-OH(Na-Boc-2,3-DiaMinopropionic acid)
  • Z-L-DAP
  • (S)-3-Amino-2-(carbobenzoxyamino)propionic Acid &gt
  • (S)-3-Amino-2-(benzyloxycarbonylamino)-propanoicaci
  • (S)-Nalpha-Cbz-2,3-diaminopropionic Acid
  • 3-Amino-N-(carbobenzoxy)-L-alanine
  • Cbz-beta-Amino-L-alanine USP/EP/BP
  • Nα-Benzyloxycarbonyl-L-2,3-diamiopropionic Acid Discontinued See: C176175
  • (2S)-3-azaniumyl-2-(phenylmethoxycarbonylamino)propanoate
  • Nα-Z-L-2,3-diaminopropionic acid
  • (2S)-3-amino-2-benzyloxycarbonylaminopropionic acid