ChemicalBook > CAS DataBase List > 4-(4-Aminophenyl)piperazine-1-carboxylic acid tert-butyl ester

4-(4-Aminophenyl)piperazine-1-carboxylic acid tert-butyl ester

Product Name
4-(4-Aminophenyl)piperazine-1-carboxylic acid tert-butyl ester
CAS No.
170911-92-9
Chemical Name
4-(4-Aminophenyl)piperazine-1-carboxylic acid tert-butyl ester
Synonyms
Itraconazole Impurity 54;4-(4-Boc-piperazin-1-yl)aniline;1-BOC-4-(4'-AMINOPHENYL)PIPERAZINE;4-(4-Aminophenyl)piperazine, N1-BOC protected;4-(4-aminophenyl)-1-t-butyloxycarbonylpiperazine;4-(4-Aminophenyl)piperazine, N1-BOC protected 98%;t-Butyl 4-(4-aminophenyl)piperazine-1-carboxylate;TERT-BUTYL 4-(4-AMINOPHENYL)PIPERAZINE-1-CARBOXYLATE;4-(4-AMINOPHENYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;4-(4-Aminophenyl)piperazine-1-carboxylic acid tert-butyl est...
CBNumber
CB9726019
Molecular Formula
C15H23N3O2
Formula Weight
277.36
MOL File
170911-92-9.mol
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4-(4-Aminophenyl)piperazine-1-carboxylic acid tert-butyl ester Property

Boiling point:
441.1±40.0 °C(Predicted)
Density 
1.145±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
pka
7.69±0.10(Predicted)
form 
Solid
Appearance
Brown to reddish brown Solid
Water Solubility 
Slightly soluble in water.
InChI
InChI=1S/C15H23N3O2/c1-15(2,3)20-14(19)18-10-8-17(9-11-18)13-6-4-12(16)5-7-13/h4-7H,8-11,16H2,1-3H3
InChIKey
RXFHRKPNLPBDGE-UHFFFAOYSA-N
SMILES
N1(C(OC(C)(C)C)=O)CCN(C2=CC=C(N)C=C2)CC1
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Safety

HS Code 
2921420090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical
Product number
A3499
Product name
tert-Butyl 4-(4-Aminophenyl)piperazine-1-carboxylate
Packaging
5G
Price
$63
Updated
2025/07/31
TCI Chemical
Product number
A3499
Product name
tert-Butyl 4-(4-Aminophenyl)piperazine-1-carboxylate
Packaging
25G
Price
$190
Updated
2025/07/31
TRC
Product number
B621140
Product name
1-Boc-4-(4-aminophenyl)piperazine
Packaging
5g
Price
$330
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA56975
Product name
4-(4-Aminophenyl)piperazine-1-carboxylic acid tert-butyl ester
Packaging
1g
Price
$40
Updated
2021/12/16
Chem-Impex
Product number
24311
Product name
4-(4-Aminophenyl)piperazine-1-carboxylicacidtert-butylester,97%(HPLC)
Purity
97%(HPLC)
Packaging
1G
Price
$50.4
Updated
2021/12/16
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4-(4-Aminophenyl)piperazine-1-carboxylic acid tert-butyl ester Chemical Properties,Usage,Production

Uses

1-Boc-4-(4-aminophenyl)piperazine is a important organic intermediate. It can be used in agrochemical, pharmaceutical and dyestuff.

Synthesis

182618-86-6

170911-92-9

The general procedure for the synthesis of tert-butyl 4-(4-aminophenyl)piperazine-1-carboxylate from tert-butyl 4-(4-nitrophenyl)piperazine-1-carboxylate was as follows: first, tert-butyl 4-(4-nitrophenyl)piperazine-1-carboxylate (8.2 g, 26.68 mmol) was dissolved in methanol (100 mL), followed by purging with nitrogen and depressurization. Next, 10% wet palladium carbon catalyst was added to the solution and the hydrogenation reaction was carried out under hydrogen pressure of 50 psi for 16 hours. Upon completion of the reaction, the mixture was filtered through diatomaceous earth to remove the catalyst, and the filtrate was subsequently concentrated under reduced pressure to afford tert-butyl 4-(4-aminophenyl)piperazine-1-carboxylate (7.4 g, 97% yield) as a dark blue oily product, which was used directly in subsequent reactions without further purification. The molecular formula of the product was C15H23N3O2, and the mass spectrometry analysis showed that the m/z was 277.9 (M + H).

References

[1] Patent: WO2006/38039, 2006, A1. Location in patent: Page/Page column 17; 30
[2] Patent: EP1215208, 2002, A2. Location in patent: Example C(101)
[3] Patent: WO2012/110773, 2012, A1. Location in patent: Page/Page column 52; 53
[4] Patent: WO2014/26242, 2014, A1. Location in patent: Page/Page column 77
[5] Patent: WO2014/27199, 2014, A1. Location in patent: Page/Page column 55

4-(4-Aminophenyl)piperazine-1-carboxylic acid tert-butyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

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4-(4-Aminophenyl)piperazine-1-carboxylic acid tert-butyl ester Suppliers

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View Lastest Price from 4-(4-Aminophenyl)piperazine-1-carboxylic acid tert-butyl ester manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
1-Piperazinecarboxylic acid, 4-(4-aMinophenyl)-, 1,1-diMethylethyl ester 170911-92-9
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-06-27
Career Henan Chemical Co
Product
4-(4-Aminophenyl)piperazine-1-carboxylic acid tert-butyl ester 170911-92-9
Price
US $6.68/KG
Min. Order
1KG
Purity
97%-99%
Supply Ability
1kg-1000kg
Release date
2020-01-10
Career Henan Chemical Co
Product
4-(4-Aminophenyl)piperazine-1-carboxylic acid tert-butyl ester 170911-92-9
Price
US $6.68/KG
Min. Order
1KG
Purity
97%-99%
Supply Ability
1kg-1000kg
Release date
2020-01-10

170911-92-9, 4-(4-Aminophenyl)piperazine-1-carboxylic acid tert-butyl esterRelated Search:

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