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MMP INHIBITOR II

Product Name
MMP INHIBITOR II
CAS No.
203915-59-7
Chemical Name
MMP INHIBITOR II
Synonyms
MMP INHIBITOR II;N-hydroxy-1,3-bis[(4-methoxyphenyl)sulfonyl]-5,5-dimethyl-1,3-diazinane-2-carboxamide;N-HYDROXY-1,3-DI-(4-METHOXYBENZENESULPHONYL)-5,5-DIMETHYL-[1,3]-PIPERAZINE-2-CARBOXAMIDE;2-Pyrimidinecarboxamide, hexahydro-N-hydroxy-1,3-bis[(4-methoxyphenyl)sulfonyl]-5,5-dimethyl-
CBNumber
CB9726695
Molecular Formula
C21H27N3O8S2
Formula Weight
513.58
MOL File
Mol file
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MMP INHIBITOR II Property

Density 
1.385±0.06 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
Soluble in DMSO
form 
Solid
pka
9.53±0.23(Predicted)
color 
off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
444247
Product name
MMP Inhibitor II - CAS 203915-59-7 - Calbiochem
Purity
The MMP Inhibitor II, also referenced under CAS 203915-59-7, controls the biological activity of MMP. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
Packaging
1MG
Price
$187
Updated
2024/03/01
Cayman Chemical
Product number
15958
Product name
MMP Inhibitor II
Purity
≥95%
Packaging
1mg
Price
$63
Updated
2024/03/01
Cayman Chemical
Product number
15958
Product name
MMP Inhibitor II
Purity
≥95%
Packaging
5mg
Price
$169
Updated
2024/03/01
Cayman Chemical
Product number
15958
Product name
MMP Inhibitor II
Purity
≥95%
Packaging
10mg
Price
$275
Updated
2024/03/01
ApexBio Technology
Product number
C4081
Product name
MMP Inhibitor II
Packaging
10mg
Price
$312
Updated
2021/12/16
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MMP INHIBITOR II Chemical Properties,Usage,Production

Uses

A potent, reversible, broad range inhibitor of matrix metalloproteinases

Biological Activity

mmp inhibitor ii is a potent, reversible and broad-range inhibitor of matrix metalloproteinases (mmps) with ic50 values of 24 nm, 18.4 nm, 30 nm and 2.7 nm for mmp-1, mmp-3, mmp-7 and mmp-9, respectively [1].mmps belong to a family of at least fifteen secreted and membrane-bound zinc-endopeptidases. mmps have been engaged in several pathological processes, including tumor growth and metastasis, arthritis, multiple sclerosis, and periodontal disease. these enzymes play a vital role in tissue repair and remodeling via degrading all the extracellular matrix components, including fibrallar and non-fibrallar collagens, laminin, fibronectin, and basement membrane glycoproteins, which enables cell migration. in addition, mmps exert function in metastasis by promoting tumor invasion and angiogenesis. it was shown that the expression of various members of the mmp family by tumors is closely associated with their proliferative and invasive behavior and metastatic potential. furthermore, mmps are broadly sub-divided into three classes: stromelysins, gelatinases, and collagenases, which are secreted in a proenzyme form and require activation to digest an extracellular matrix [1].

IC 50

MMP-1: 24 nM (IC50); MMP-3: 18.4 nM (IC50); MMP-7: 30 nM (IC50); MMP-9: 2.7 nM (IC50)

References

[1]. slawomir m. wojtowicz-praga, robert b. dickson and michael j. hawkins. matrix metalloproteinase inhibitors. investigational new drugs. 1997; 15: 61–75.

MMP INHIBITOR II Preparation Products And Raw materials

Raw materials

Preparation Products

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MMP INHIBITOR II Suppliers

CHINA 13 Japan 1 United Kingdom 1 United States 6 Global 21
VDM Biochemicals
Tel
0330-2528181
Fax
0330-2528171
Email
sales@vdmbio.com
Country
United States
ProdList
510
Advantage
64
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11218
Advantage
58
MedBioPharmaceutical Technology Inc
Tel
021-69568360 18916172912
Email
order@med-bio.cn
Country
China
ProdList
8140
Advantage
58
Shanghai Yifei Biotechnology Co. , Ltd.
Tel
021-65675885 18964387627
Email
customer_service@efebio.com
Country
China
ProdList
11973
Advantage
58
Nantong Hanfang Biotechnology Co. , Ltd.
Tel
hanfangpharma@126.com; 18616537568
Email
hanfangpharma@126.com
Country
China
ProdList
29965
Advantage
58
Cayman Chemical Company
Tel
800-364-9897
Email
sales@caymanchem.com
Country
China
ProdList
6838
Advantage
58
Merck KGaA
Tel
21-20338288
Email
ordercn@merckgroup.com
Country
China
ProdList
6394
Advantage
58
Biosynth Biological Technology (Suzhou) Co Ltd
Tel
51288865780
Email
sales@biosynth.com
Country
China
ProdList
6051
Advantage
58
Santa Cruz Biotechnology Inc
Tel
021-60936350
Email
scbt@scbt.com
Country
China
ProdList
6594
Advantage
58
Aladdin Scientific
Tel
Email
tp@aladdinsci.com
Country
United States
ProdList
52923
Advantage
58

203915-59-7, MMP INHIBITOR IIRelated Search:

MMP INHIBITOR I

  • N-HYDROXY-1,3-DI-(4-METHOXYBENZENESULPHONYL)-5,5-DIMETHYL-[1,3]-PIPERAZINE-2-CARBOXAMIDE
  • MMP INHIBITOR II
  • N-hydroxy-1,3-bis[(4-methoxyphenyl)sulfonyl]-5,5-dimethyl-1,3-diazinane-2-carboxamide
  • 2-Pyrimidinecarboxamide, hexahydro-N-hydroxy-1,3-bis[(4-methoxyphenyl)sulfonyl]-5,5-dimethyl-
  • 203915-59-7
  • C21H27N3O8S2