RO 106-9920
- Product Name
- RO 106-9920
- CAS No.
- 62645-28-7
- Chemical Name
- RO 106-9920
- Synonyms
- RO 106-9920;Ro 106 9920,Ro 1069920;Ro 106-9920 DISCONTINUED;TETRAZOLOPYRIDAZINE-PHENYLSULFOXIDE;6-(PHENYLSULFINYL)TETRAZOLO[1,5-B]PYRIDAZINE;Tetrazolo[1,5-b]pyridazine, 6-(phenylsulfinyl)-
- CBNumber
- CB9728932
- Molecular Formula
- C10H7N5OS
- Formula Weight
- 245.26
- MOL File
- 62645-28-7.mol
RO 106-9920 Property
- storage temp.
- Store at +4°C
- solubility
- Soluble to 5 mM in ethanol and to 100 mM in DMSO
- form
- White solid
N-Bromosuccinimide Price
- Product number
- 557550
- Product name
- Ro 106-9920
- Packaging
- 1mg
- Price
- $159
- Updated
- 2024/03/01
- Product number
- 15373
- Product name
- Ro 106-9920
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $49
- Updated
- 2024/03/01
- Product number
- 15373
- Product name
- Ro 106-9920
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $109
- Updated
- 2024/03/01
- Product number
- 15373
- Product name
- Ro 106-9920
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $158
- Updated
- 2024/03/01
- Product number
- 256474
- Product name
- Ro 106-9920
- Packaging
- 10mg
- Price
- $409
- Updated
- 2021/12/16
RO 106-9920 Chemical Properties,Usage,Production
Uses
Ro 106-9920 is an inhibitor of NF-κB activation, possibly via selective inhibition of LPS- and TNF-α-induced IκBα ubiquitination (IC50 = 3 μM). Ro 106-9920 blocks subsequent production of TNF-α, IL-1β and IL-6. Inhibits mucin production in an in vitro model of COPD, and is anti-inflammatory following oral administration in vivo. Also weakly inhibits EGFR, 5-lipoxygenase and iNOS.
Definition
ChEBI: 6-(benzenesulfinyl)tetrazolo[1,5-b]pyridazine is a sulfoxide.
Biological Activity
Inhibitor of NF- κ B activation, possibly via selective inhibition of LPS- and TNF- α -induced I κ B α ubiquitination (IC 50 = 3 μ M). Blocks subsequent production of TNF- α , IL-1 β and IL-6. Inhibits mucin production in an in vitro model of COPD, and is anti-inflammatory following oral administration in vivo . Also weakly inhibits EGFR, 5-lipoxygenase and iNOS.
RO 106-9920 Preparation Products And Raw materials
Raw materials
Preparation Products
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