ChemicalBook > CAS DataBase List > RO 106-9920

RO 106-9920

Product Name
RO 106-9920
CAS No.
62645-28-7
Chemical Name
RO 106-9920
Synonyms
RO 106-9920;Ro 106 9920,Ro 1069920;Ro 106-9920 DISCONTINUED;TETRAZOLOPYRIDAZINE-PHENYLSULFOXIDE;6-(PHENYLSULFINYL)TETRAZOLO[1,5-B]PYRIDAZINE;Tetrazolo[1,5-b]pyridazine, 6-(phenylsulfinyl)-
CBNumber
CB9728932
Molecular Formula
C10H7N5OS
Formula Weight
245.26
MOL File
62645-28-7.mol
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RO 106-9920 Property

storage temp. 
Store at +4°C
solubility 
Soluble to 5 mM in ethanol and to 100 mM in DMSO
form 
White solid
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
557550
Product name
Ro 106-9920
Packaging
1mg
Price
$159
Updated
2024/03/01
Cayman Chemical
Product number
15373
Product name
Ro 106-9920
Purity
≥95%
Packaging
1mg
Price
$49
Updated
2024/03/01
Cayman Chemical
Product number
15373
Product name
Ro 106-9920
Purity
≥95%
Packaging
5mg
Price
$109
Updated
2024/03/01
Cayman Chemical
Product number
15373
Product name
Ro 106-9920
Purity
≥95%
Packaging
10mg
Price
$158
Updated
2024/03/01
Usbiological
Product number
256474
Product name
Ro 106-9920
Packaging
10mg
Price
$409
Updated
2021/12/16
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RO 106-9920 Chemical Properties,Usage,Production

Uses

Ro 106-9920 is an inhibitor of NF-κB activation, possibly via selective inhibition of LPS- and TNF-α-induced IκBα ubiquitination (IC50 = 3 μM). Ro 106-9920 blocks subsequent production of TNF-α, IL-1β and IL-6. Inhibits mucin production in an in vitro model of COPD, and is anti-inflammatory following oral administration in vivo. Also weakly inhibits EGFR, 5-lipoxygenase and iNOS.

Definition

ChEBI: 6-(benzenesulfinyl)tetrazolo[1,5-b]pyridazine is a sulfoxide.

Biological Activity

Inhibitor of NF- κ B activation, possibly via selective inhibition of LPS- and TNF- α -induced I κ B α ubiquitination (IC 50 = 3 μ M). Blocks subsequent production of TNF- α , IL-1 β and IL-6. Inhibits mucin production in an in vitro model of COPD, and is anti-inflammatory following oral administration in vivo . Also weakly inhibits EGFR, 5-lipoxygenase and iNOS.

RO 106-9920 Preparation Products And Raw materials

Raw materials

Preparation Products

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RO 106-9920 Suppliers

China 47 Germany 2 India 1 Switzerland 1 United Kingdom 1 United States 8 Global 60
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62645-28-7, RO 106-9920Related Search:

RO 106-9920, CONTROL 5-METHYL-1-AMINOTETRAZOLE RO 106-9920

  • RO 106-9920
  • TETRAZOLOPYRIDAZINE-PHENYLSULFOXIDE
  • 6-(PHENYLSULFINYL)TETRAZOLO[1,5-B]PYRIDAZINE
  • Tetrazolo[1,5-b]pyridazine, 6-(phenylsulfinyl)-
  • Ro 106-9920 DISCONTINUED
  • Ro 106 9920,Ro 1069920
  • 62645-28-7
  • BioChemical
  • Cell Biology
  • Cell Signaling and Neuroscience
  • Gene Regulation and Expression
  • Gene Regulation
  • Cytokine signaling
  • Aromatics
  • Heterocycles
  • Inhibitors
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Sulfur & Selenium Compounds